Serological survey for antibodies to Encephalitozoon cuniculi in rabbits in Taiwan

Tee, Kai-Yee; Kao, Ju-Po; Chiu, Hsin-Yu; Chang, Ming-Huang; Wang, Jiann-Hsiung; Tung, Kwong‐Chung; Cheng, Fei-Fei; Wu, Jui-Te

doi:10.1016/j.vetpar.2011.06.011

Cited by 20 publications

(15 citation statements)

References 14 publications

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“…No differences between the groups were ascertained with regard to gender distribution. This is in accord with the results of previous studies (Meyer-Breckwoldt 1996, Keeble and Shaw 2006, Tee and others 2011). …”

Section: Discussionsupporting

confidence: 94%

“…Thirty-three of the diseased animals (21 Group B1, 12 Group B2) were tested via CIA, all confirmed by postmortem examination or urine PCR. The CIA also showed a very good correlation (0.98) to the IFAT (Waller 1977, Tee and others 2011). A retroactive performance of a second test was not feasible, which means it is impossible to compare the results of the two antibody testing procedures.…”

Section: Discussionmentioning

confidence: 74%

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Encephalitozoon cuniculi in rabbits in Germany: prevalence and sensitivity of antibody testing

Hein¹,

Flock²,

Sauter‐Louis³

et al. 2014

Veterinary Record

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The aim of this study was to investigate the prevalence of Encephalitozoon cuniculi antibodies in healthy and diseased rabbits in Germany. Age and gender dependencies were taken into consideration. The sensitivity of the E cuniculi antibody test and its relevance for the diagnosis of E cuniculi infection in rabbits was also examined. A total of 773 healthy and diseased rabbits were tested for E cuniculi antibodies (indirect immune fluorescence antibody test (IFAT) or carbon immunoassay (CIA). No differences between diseased and healthy rabbits were observed with regard to gender, but diseased rabbits were significantly older (P>0.001). Forty-three percent (336/773) of all rabbits were positive for E cuniculi antibodies. Of the diseased rabbits, 48 per cent (266/555) were positive for E cuniculi antibodies. While 96 per cent (91/95) of the rabbits with histopathologically or PCR confirmed encephalitozoonosis were E cuniculi antibody-positive, only 60 per cent (144/241) of the rabbits suspected of E cuniculi infection were antibody-positive. Of the healthy rabbits, 18 per cent (39/218) were positive for E cuniculi antibodies. Diseased rabbits were almost three times more likely to be E cuniculi antibody-positive than healthy ones (P>0.001; relative risk (RR): 2.68; 95% CI 1.99 to 3.61). The sensitivity of the E cuniculi antibody test was 96 per cent.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 74%

Encephalitozoon cuniculi in rabbits in Germany: prevalence and sensitivity of antibody testing

Hein¹,

Flock²,

Sauter‐Louis³

et al. 2014

Veterinary Record

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show abstract

“…From statistical analysis using Statistical Package for the Social Sciences (SPSS, IBM, USA), rabbit gender (χ 2 =0.691, P =0.406), age (χ 2 =0.549, P =0.76), and health status (χ 2 =0.319, P =0.116) did not have any significant effect on E. cuniculi infection, as reported by other studies [9,10,11,12], which is in contrast to the reports presented by Dipineto et al [9], Santaniello et al [11] and Tee et al [12]. …”

supporting

confidence: 53%

Seroprevalence of Encephalitozoon cuniculi in Pet Rabbits in Korea

Shin

Kim

et al. 2014

Korean J Parasitol

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Encephalitozoon cuniculi is a microsporidian parasite commonly found in rabbits that can infect humans, causing encephalitozoonosis. The prevalence of encephalitozoonosis is not well documented, even when many clinics suspect pet rabbits as being highly infected. This study investigated the seropositivity of E. cuniculi using ELISA. The examination of 186 rabbits using ELISA showed that 22.6% (42/186) were seropositive against E. cuniculi. In analysis with healthy status, all 42 seropositive sera were collected from clinically normal rabbits. Moreover, the gender and age of pet rabbits did not have anysignificant effect on E. cuniculi infection. To the best of our knowledge, this is the first report to describe the seroprevalence of E. cuniculi in pet rabbits and suggests that pet rabbits could act as an important reservoir of encephalitozoonosis for both pet animals and humans in Korea.

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“…The serological results of this study revealed an overall seropositive rate (21.9%) of E. cuniculi infection in domestic meat rabbits detected by ELISA, which was much lower than the 67.8% prevalence among 171 rabbits in Taiwan [ 11 ], 58.5% in 118 rabbits in Austria [ 1 ], and 67.2% in pet rabbits in Italy [ 12 ]. However, the prevalence was much higher than the values of 15% in farmed domestic rabbits in Egypt [ 13 ], 7.7% in New Zealand rabbits in Turkey [ 14 ], and 22.6% in pet rabbits in Korea [ 15 ].…”

mentioning

confidence: 84%

“…A commercial ELISA kit (Medicago, Uppsala, Sweden) was used to detect and verify antibodies against E. cuniculi in rabbit sera [ 11 ]. The procedure was performed following the kit manufacturer’s instructions.…”

mentioning

confidence: 99%

Seroprevalence of Encephalitozoon cuniculi and Toxoplasma gondii in domestic rabbits (Oryctolagus cuniculus) in China

Meng

Wang

et al. 2015

Korean J Parasitol

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The breeding of domestic rabbits (Oryctolagus cuniculus) for human consumption has a long tradition in China. Infections that can affect the production of meat or even be transmitted from animals to humans are important to monitor, especially for public health reasons as well as for their impact on animal health. Thus, a total of 1,132 domestic rabbit sera from 4 regions in China were collected for serological screening for Encephalitozoon cuniculi and for Toxoplasma gondii by ELISA and modified agglutination test (MAT), respectively. Antibodies to E. cuniculi were detected in 248/1,132 (21.9%) sera tested while antibodies against T. gondii revealed a seroprevalence of 51/1,132 (4.5%). We believe that the present results are of epidemiological implications and public health importance due to the acknowledged susceptibility of humans to E. cuniculi and T. gondii infections. Therefore, routine screening tests of domestic rabbits are proposed considering the zoonotic potential of these parasites.

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Serological survey for antibodies to Encephalitozoon cuniculi in rabbits in Taiwan

Cited by 20 publications

References 14 publications

Encephalitozoon cuniculi in rabbits in Germany: prevalence and sensitivity of antibody testing

Encephalitozoon cuniculi in rabbits in Germany: prevalence and sensitivity of antibody testing

Seroprevalence of Encephalitozoon cuniculi in Pet Rabbits in Korea

Seroprevalence of <i>Encephalitozoon cuniculi</i> and <i>Toxoplasma gondii</i> in domestic rabbits (<i>Oryctolagus cuniculus</i>) in China

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Serological survey for antibodies to Encephalitozoon cuniculi in rabbits in Taiwan

Cited by 20 publications

References 14 publications

Encephalitozoon cuniculi in rabbits in Germany: prevalence and sensitivity of antibody testing

Encephalitozoon cuniculi in rabbits in Germany: prevalence and sensitivity of antibody testing

Seroprevalence of Encephalitozoon cuniculi in Pet Rabbits in Korea

Seroprevalence of &lt;i&gt;Encephalitozoon cuniculi&lt;/i&gt; and &lt;i&gt;Toxoplasma gondii&lt;/i&gt; in domestic rabbits (&lt;i&gt;Oryctolagus cuniculus&lt;/i&gt;) in China

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Seroprevalence of <i>Encephalitozoon cuniculi</i> and <i>Toxoplasma gondii</i> in domestic rabbits (<i>Oryctolagus cuniculus</i>) in China