Serological screening suggests that adult coeliac disease is underdiagnosed in the UK and increases the incidence by up to 12%.

Abstract

Because coeliac disease often presents atypically it is underdiagnosed. It is suggested that the detection rate may be increased by 12% if serology is used to identify cases of occult enteropathy. Ali adults noted incidentally to be Rl anti-reticulin antibody (ARA) positive in the course of routine autoantibody testing of 6532 sera over one year were followed. None of the eight patients with seropositive serum was suspected of having coeliac disease. All

Prevalence of Coeliac Disease: Unexplained Age-related Variation in the Same Population

“…This study confirms that CD remains largely undiagnosed in Brazil, similarly to other countries (12,13). In a sample of 4405 subjects with no previously recognized case, we found 16 cases of CD mostly affected with atypical forms.…”

The Prevalence of Celiac Disease in Patients With Iron-Deficiency Anemia in Center and South Area of Iran

“…Monosymptomatic, oligosymptomatic, atypical, silent and latent types of CD have been identified (4,35) as CD today often presents atypically, it is underdiagnosed. It is recommended that the detection rate might be improved by 12% when serology is employed to determine cases of occult enteropathy (38,46) . Serologic antibody tests are indicated for all people in whom celiac disease is (even remotely) presumed, and also for all persons considered to be at risk for the disease (33) .…”

Celiac disease in patients with presumed irritable bowelsyndrome: A case-fnding study

“…In fact, many patients -especially those presenting in adulthood -have minimal or atypical symptoms [5,[7][8][9][10] . The recent development of highly sensitive and specific serologic assays for CD has led to the increased realisation that the disease is more common than it was believed [11][12][13][14][15] . This justifies the concern that some IBSlabeled patients may in fact have CD.…”