Serological screening of Chagas disease in an immigrant population in Asturias, Spain proceeding from Chagas-endemic areas

Rodríguez-Guardado, Azucena; Rodríguez, Mercedes; Alonso, Paula Rodríguez; Seco, Carolina; Flóres-Chávez, María; Mejuto, P; Cartón, José A.

doi:10.1080/00365540903161523

Cited by 15 publications

(10 citation statements)

References 9 publications

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“…The implementation of screening programs for migrant populations is necessary for early diagnosis of Chagas disease [6, 9]. …”

Section: Discussionmentioning

confidence: 99%

“…Due to migration of Latin Americans, an increasing public health impact has been observed in nonendemic countries, such as in Australia, Canada, Japan, Spain, and the United States [5–7, 9]. Thus, the overlap of HIV infection and T. cruzi may occur not only in endemic areas, but also in wealthier regions that receive an increasing number of potentially infected migrants [1, 6].…”

Section: Introductionmentioning

confidence: 99%

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Mortality Related to Chagas Disease and HIV/AIDS Coinfection in Brazil

Martins-Melo

Ramos

Alencar

et al. 2012

Journal of Tropical Medicine

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Chagas disease in patients with HIV infection represents a potentially serious event with high case fatality rates. This study describes epidemiological and clinical aspects of deaths related to Chagas disease and HIV/AIDS coinfection in Brazil, 1999–2007. We performed a descriptive study based on mortality data from the nationwide Mortality Information System. Of a total of about 9 million deaths, Chagas disease and HIV/AIDS were mentioned in the same death certificate in 74 cases. AIDS was an underlying cause in 77.0% (57) and Chagas disease in 17.6% (13). Males (51.4%), white skin color (50%), age group 40–49 years (29.7%), and residents in the Southeast region (75.7%) were most common. Mean age at death was significantly lower in the coinfected (47.1 years [SD ± 14.6]), as compared to Chagas disease deaths (64.1 years [SD ± 14.7], P < 0.001). Considering the lack of data on morbidity related to Chagas disease and AIDS coinfection, the use of mortality data may be an appropriate sentinel approach to monitor the occurrence of this association. Due to the epidemiological transition in Brazil, chronic Chagas disease and HIV/AIDS coinfection will be further complicated and require the development of evidence-based preventive control measures.

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“…The implementation of screening programs for migrant populations is necessary for early diagnosis of Chagas disease [6, 9]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mortality Related to Chagas Disease and HIV/AIDS Coinfection in Brazil

Martins-Melo

Ramos

Alencar

et al. 2012

Journal of Tropical Medicine

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“…Cancino 2015 [32] Frank 1997 [24] Paricio-Talayero 2008 [43] Angheben 2011 [23] Martínez 2009 [38] Angheben 2011 [23] Roca 2011 [9] Ramos 2012 [29] Study Perez-Ayala 2010 [6] Angheben 2011 [23] Soriano 2009 [31] Avila Arzanegui 2013 [36] Barona-Vilar 2012 [37] O'Brien 2013 [35] Perez-Molina 2011 [28] Otero…”

Section: Muñoz-vilches 2012 [40]mentioning

confidence: 99%

“…Nine observational studies yielded a cumulative prevalence of severe cardiac events of 1% (95% CI: 0-2%; 39 events in 1,946 patients) [6,7,9,24,29,[45][46][47][48]. The estimated cumulative prevalence of megasyndrome was lower (0%; 95% CI: 0-1%; 45 events in 1,935 patients) [6,7,9,24,25,28,29,[45][46][47][48].…”

Section: Organ Involvementmentioning

confidence: 99%

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Screening for Trypanosoma cruzi infection in immigrants and refugees: Systematic review and recommendations from the Spanish Society of Infectious Diseases and Clinical Microbiology

et al. 2020

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Background: Chagas disease has spread beyond its original borders on the American continent with migration. It can be transmitted from mother to child, through organ transplantation and transfusion of blood and blood products. It is necessary to determine when to screen for this infection. Aim: Our objective was to evaluate the appropriateness of screening for Trypanosoma cruzi infection in Latin American migrants and their descendants. Methods: We reviewed the literature using rigorous criteria. The quality of evidence was ranked according to the GRADE classification. An evidence to decision framework was adopted to provide information on the most relevant aspects necessary to formulate recommendations. Results: The 33 studies evaluated revealed a prevalence of T. cruzi infection among Latin American migrants in Europe of 6.08% (95% confidence interval (CI): 3.24-9.69; 28 studies). Vertical transmission occurred in three of 100 live births (95% CI: 1-6; 13 studies). The prevalence of cardiovascular disease was 19% (95% CI: 13-27; nine studies), including only 1% severe cardiac events (95% CI: 0-2; 11 studies). The overall quality of evidence was low because of risk of bias in the studies and considerable heterogeneity of the evaluated populations. The recommendations took into account economic studies on the value of screening strategies and studies on acceptability of screening and knowledge of the disease in the affected population. Conclusions: We identified five situations in which screening for T. cruzi infection is indicated. We recommend screening persons from endemic areas and children of mothers from these areas.

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Chagas disease screening among HIV-positive Latin American immigrants: an emerging problem

Llenas-García

Hernando

Fiorante

et al. 2012

Eur J Clin Microbiol Infect Dis

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Chagas disease (CD) is an emergent disease in Europe that can behave as an opportunistic infection in HIV positive patients. The objective of this study was to evaluate the implementation of a CD screening programme in an HIV unit. An immunochromatography (ICT) of Trypanosoma cruzi was performed as a screening tool in HIV-positive patients born in CD endemic countries. ELISA and IFAT were used to confirm the diagnosis. A total of 155 patients, 116 males and 38 females, were included. Mean age was 36.9 years (± 8.4) and mean length of stay in Spain at the screening was 7.1 years (± 4.7). T. cruzi ICT was positive in four cases (2.6%), being confirmed (by ELISA and IFAT) in three of those (1.9%). Factors associated with confirmed positive T.cruzi serology were: Bolivia origin (p=0.016), Bolivia or Argentina origin (p=0.002), Southern Cone origin (p=0.015), rural origin (p=0.023), previously living in an adobe-made (p=0.001) or thatch-roofed house (p<0.0001), having a previous CD test (p=0.015), previous knowledge about CD (p=0.019), about vector (p=0.009) or recorded seeing vectors at home (p=0.012). Units dealing with HIV patients from endemic areas of American trypanosomiasis should implement CD screening protocols. Interviews of patients coming from endemic areas should include CD epidemiological questions.

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Serological screening of Chagas disease in an immigrant population in Asturias, Spain proceeding from Chagas-endemic areas

Cited by 15 publications

References 9 publications

Mortality Related to Chagas Disease and HIV/AIDS Coinfection in Brazil

Mortality Related to Chagas Disease and HIV/AIDS Coinfection in Brazil

Screening for Trypanosoma cruzi infection in immigrants and refugees: Systematic review and recommendations from the Spanish Society of Infectious Diseases and Clinical Microbiology

Chagas disease screening among HIV-positive Latin American immigrants: an emerging problem

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