Serological screening for celiac disease in symptomatic 12 to 36 month-old children

Modelli, Inês Cristina; Gandolfi, Lenora; Almeida, Rodrigo Coutinho de; Araújo, Gloria Maria A. C; Picanço, Marilúcia de Almeida Rocha; Pratesi, Riccardo

doi:10.1590/s0004-28032010000100011

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…A total of 27 studies comprising 28 articles were included in the model [ 50 , 52 , 54 , 55 , 66 , 69 , 71 – 74 , 78 , 80 , 82 , 83 , 85 – 87 , 89 , 90 , 94 , 97 , 100 , 114 , 116 – 118 , 121 , 122 ]. The work of Remes-troche, et al .…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Celiac Disease in Latin America: A Systematic Review and Meta-Regression

et al. 2015

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BackgroundCeliac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Given that information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the world through a systematic review and meta-analysis.Methods and FindingsThis was a two-phase study. First, a cross-sectional analysis from 981 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were performed following the Preferred Reporting Items for Systematic Meta- Analyses (PRISMA) guidelines. Our results disclosed a lack of celiac autoimmunity in the studied Colombian population (i.e., anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA)). In the systematic review, 72 studies were considered. The estimated prevalence of CD in Latin Americans ranged between 0.46% and 0.64%. The prevalence of CD in first-degree relatives of CD probands was 5.5%. The coexistence of CD and type 1 diabetes mellitus varied from 4.6% to 8.7%, depending on the diagnosis methods (i.e., autoantibodies and/or biopsies).ConclusionsAlthough CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans.

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