Serological response to a booster foot-and-mouth disease vaccination with strains different from the primary vaccine

Abstract

Young calves were vaccinated with belgian foot-and-mouth disease (FMD) vaccine and revaccinated with either the same vaccine or with a foreign FMD vaccine. There was a significant serological response to the primary vaccine strains after the first vaccination which was greater following revaccination. At one and two months after revaccination there was no significant difference between the responses to revaccination with vaccine identical to the primary vaccine or with the foreign FMD vaccine. It was concluded that revaccination of young calves is effective even with an FMD vaccine different from the primary vaccine.

Heterologous Prime-Boost Vaccination with Commercial FMD Vaccines Elicits a Broader Immune Response than Homologous Prime-Boost Vaccination in Pigs

“…Similar to our study, no significant difference between calves vaccinated with the same or different vaccines as booster vaccines in VN titer against strains contained in the primed vaccine was observed in a cattle experiment [ 19 ]. Although the aim of the cattle study was to evaluate whether the interaction with different vaccines applied in prime-boost vaccination would interfere with protective efficacy, it was concluded that similar VN titers were to be expected because type O, A, and C vaccine strains contained in three different vaccines (Belgian, Dutch, and Italian trivalent vaccine) were antigenically closely related, except for the type A vaccine strain in the Dutch vaccine, according to the r 1 -values for the same serotype vaccine strains.…”