Serological response of guinea pigs to oily and aqueous inactivated vaccines containing a Brazilian isolate of the Bovine Viral Diarrhea Virus (BVDV)

Jordão, R. S.; Ribeiro, Cristiane Maria; Pituco, Edviges Maristela; Okuda, Líria Hiromi; Fava, Cláudia Del; Stéfano, Eliana de; Filho, Moacir Marchiori; Mehnert, Dolores Ursula

doi:10.1016/j.rvsc.2010.12.010

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Although the control measures for eradication, namely selective test and slaughter as well as vaccination, are widely used, BVDV remains prevalent due to its diversified antigenicity. The efficiency and the specificity of RNAi are attractive therapeutic characteristics that may prove useful for the development of antiviral therapies (Lambeth et al, 2007;Zemke et al, 2010;Jordao et al, 2011). Constant changes in the antigenic regions of BVDV structure, particularly C, Erns, E1, and E2 antigens and the formation of scape mutants that evade the host immune response, have made the production of an effective vaccine difficult.…”

Section: Discussionmentioning

confidence: 99%

“…Constant changes in the antigenic regions of BVDV structure, particularly C, Erns, E1, and E2 antigens and the formation of scape mutants that evade the host immune response, have made the production of an effective vaccine difficult. The majority of BVDV vaccines are designed against the previously mentioned glycoproteins and proteins, and this is a crucial factor for the medium or low success to control or eradicate the disease (Meyers and Theil, 1996;Lambeth et al, 2007;Zemke et al, 2010;Jordao et al, 2011;Ni et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Developing an Antiviral Drug Screening System for Anti-Bovine Viral Diarrhea Virus (BVDV) Therapies

Mokhtari

Mahzounieh

Madadgar

et al. 2019

J Hellenic Vet Med Soc

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Bovine viral diarrhea virus (BVDV) is an economically important animal pathogen affecting cattle. Despite the use of vaccination, test and slaughter practices, BVD remains a serious problem of cattle breeding. This study was conducted in order to develop a cell line that expresses some of BVDV sub-replicons. BVDV-NADL NS3 and 5’UTR were cloned in pWPI-linker B lentiviral plasmid at the upstream of EGFP gene. Consequently, lentiviral vectors containing BVDV-NS3 and BVDV-5’UTR were produced by using the second-generation lentiviral packaging system. By these lentivectors, MDBK cells expressing BVDV-5’UTR and BVDV-NS3 partial fragments were prepared. The efficiency of the infection was evaluated by fluorescence microscopy, western blotting, and RT-PCR. The results indicated that the development of MDBK cell line expressing these transgenes provides a very sensitive antiviral drug screening system for anti-bovine viral diarrhea virus (BVDV) therapies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Developing an Antiviral Drug Screening System for Anti-Bovine Viral Diarrhea Virus (BVDV) Therapies

Mokhtari

Mahzounieh

Madadgar

et al. 2019

J Hellenic Vet Med Soc

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“…Thus, molecular methods were used to identify the BVDV vaccine antigen in this study. Aluminum hydroxide, the most common adjuvant, is used to manufacture the inactivated BVDV vaccine (Jordão et al, 2011). We used two kinds of reagents to separate vaccine antigens from the antigen/adjuvant complex in the vaccines.…”

Section: Discussionmentioning

confidence: 99%

Molecular identification of the vaccine strain from the inactivated bovine viral diarrhea virus (BVDV) vaccines

Yang¹,

Kim²,

Cho³

et al. 2013

Korean Journal of Veterinary Service

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Since the 1980's, several kinds of inactivated bovine viral diarrhea virus (BVDV) vaccines have been used to immunize domestic animals such as cattle and goat in Korea. Immunogenicity of the BVDV vaccines has been checked by the Korean Veterinary Authority using laboratory animals. In this study, we applied a molecular method to investigate the genetic characterization of the BVDV genes in six commercial inactivated BVDV vaccines, and determined the efficiency of two extraction reagents (i.e., sodium citrate or isopropyl myristate) to separate the vaccine antigens from the antigen/adjuvant complexes. Six partial non-coding regions (288 bp) were successfully amplified with specific primer sets, which demonstrated that sodium citrate is more efficient in extracting viral RNA from inactivated gel vaccines than isopropyl myristae. In addition, we identified the virus strains from the vaccines by analyzing the nucleotide sequences of the 5' non-coding region (NCR) of BVDV. The nucleotide similarity of the partial 5' NCR ranged from 95.1 to 100% among BVDV vaccine strains, respectively, indicating that a few manufacturers used different BVDV strains to produce their vaccines.

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“…Aluminum hydroxide adjuvant is the most commonly used adjuvant in commercial vaccines. Such as FMD vaccines ( 177 ), BVD vaccines ( 178 ), Brucella vaccines ( 179 ), and many others.…”

Section: Vaccine Adjuvantsmentioning

confidence: 99%

The combination of vaccines and adjuvants to prevent the occurrence of high incidence of infectious diseases in bovine

Yao,

Zhang,

Yang

2023

Front. Vet. Sci.

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As the global population grows, the demand for beef and dairy products is also increasing. The cattle industry is facing tremendous pressures and challenges. The expanding cattle industry has led to an increased risk of disease in cattle. These diseases not only cause economic losses but also pose threats to public health and safety. Hence, ensuring the health of cattle is crucial. Vaccination is one of the most economical and effective methods of preventing bovine infectious diseases. However, there are fewer comprehensive reviews of bovine vaccines available. In addition, the variable nature of bovine infectious diseases will result in weakened or even ineffective immune protection from existing vaccines. This shows that it is crucial to improve overall awareness of bovine vaccines. Adjuvants, which are crucial constituents of vaccines, have a significant role in enhancing vaccine response. This review aims to present the latest advances in bovine vaccines mainly including types of bovine vaccines, current status of development of commonly used vaccines, and vaccine adjuvants. In addition, this review highlights the main challenges and outstanding problems of bovine vaccines and adjuvants in the field of research and applications. This review provides a theoretical and practical basis for the eradication of global bovine infectious diseases.

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Serological response of guinea pigs to oily and aqueous inactivated vaccines containing a Brazilian isolate of the Bovine Viral Diarrhea Virus (BVDV)

Cited by 5 publications

References 13 publications

Developing an Antiviral Drug Screening System for Anti-Bovine Viral Diarrhea Virus (BVDV) Therapies

Developing an Antiviral Drug Screening System for Anti-Bovine Viral Diarrhea Virus (BVDV) Therapies

Molecular identification of the vaccine strain from the inactivated bovine viral diarrhea virus (BVDV) vaccines

The combination of vaccines and adjuvants to prevent the occurrence of high incidence of infectious diseases in bovine

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