Serological reactivity and bacterial genotypes in Chlamydia trachomatis urogenital infections in Guadeloupe, French West Indies

Weill, François‐Xavier; Hello, Simon Le; Clerc, M; Scribans, Cédric; Barbeyrac, Bertille de

doi:10.1136/sti.2009.037036

Cited by 10 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present finding is similar to many other surveys conducted in both high-risk and low-risk subjects (Petrovay et al, 2009;Weill et al, 2010;Yang et al, 2014;Veersteg et al, 2015;Giffard et al, 2016). Effectively, in many countries worldwide, serovars E, F, D, G and K represent the most common serovars among patients with urogenital infections, accounting for 60-80 % of positive patients (Millman et al, 2006;Pedersen et al, 2009;Lagerga rd et al, 2010;Veersteg et al, 2015).…”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Chlamydia trachomatis infection prevalence and serovar distribution in a high-density urban area in the north of Italy

Foschi

Nardini

Banzola

et al. 2016

Journal of Medical Microbiology

View full text Add to dashboard Cite

The aim of this study was to assess Chlamydia trachomatis (CT) infection prevalence and serovar distribution in a high-density urban area in the north of Italy, by comparing different groups of subjects divided on the basis of the type of care provider they referred to (STI Clinic, gynaecologists or general practitioners). From January 2011 to May 2014, all the specimens submitted to the Microbiology Laboratory of St Orsola Hospital in Bologna for CT detection were tested by PCR assay. For positive specimens, molecular genotyping based on RFLP analysis was performed. Total prevalence of CT infection was 8.1 %, with significant differences between subgroups (P<0.01) but stable during the study period. The STI Clinic was mainly responsible for CT diagnosis, whereas the lowest infection prevalence was detected in gynaecological clinics, despite the high number of tests performed. Extra-genital samples were almost exclusively collected from males at the STI Clinic. Interestingly, 13.3 % of patients providing extra-genital specimens were positive for CT on rectal and/or pharyngeal swabs, and 4.4 % of cases would have been missed if extra-genital sites had not been tested. The most common serovar was E, and serovar distribution was influenced by gender (P<0.01), age (P<0.01), care provider (P=0.01) and anatomical site (P<0.01). The L2 serovar was detected only in extragenital samples from males at the STI Clinic. Knowledge about care providers' contributions in CT testing and diagnosis is essential for infection control. CT typing is crucial for appropriate management of specific infections, such as lymphogranuloma venereum in extra-genital samples of high-risk populations.

show abstract

Section: Discussionsupporting

confidence: 79%

“…Anyway, other studies found no correlations between serovar distribution and specific patient characteristics (Weill et al, 2010;Lagerga rd et al, 2010;Veersteg et al, 2015;Giffard et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Chlamydia trachomatis infection prevalence and serovar distribution in a high-density urban area in the north of Italy

Foschi

Nardini

Banzola

et al. 2016

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…The prevalence among women visiting the FP clinic was comparable to that reported by a recent study in the Caribbean region among women in the general population [5]. Another study in the region among women who were referred for a genital infection, presumably a high-risk group for chlamydia, reported a prevalence of 11% [4], and among pregnant women a prevalence of 21% was found [6]. Studies among STI clinic visitors in the Caribbean region are scarce, but a study in Jamaica from 1999, in which chlamydia was tested by direct fluorescence assay and culture (which are now considered obsolete diagnostics), reported a prevalence of 55% [23].…”

Section: Discussionsupporting

confidence: 76%

“…The prevalence of chlamydia in the general population in many countries of the Caribbean is unknown because testing facilities are lacking and routine screening is not available. A study in Guadeloupe among patients who were referred for a genital infection, showed a prevalence of 17% among men and 10% among women [4]. A study in Barbados among the general population showed a prevalence of 11% [5] and a study in Trinidad and Tobago among pregnant women showed a prevalence of 21% [6].…”

Section: Introductionmentioning

confidence: 99%

Urogenital Chlamydia trachomatis Infections among Ethnic Groups in Paramaribo, Suriname; Determinants and Ethnic Sexual Mixing Patterns

et al. 2013

View full text Add to dashboard Cite

BackgroundLittle is known about the epidemiology of urogenital Chlamydia trachomatis infection (chlamydia) in Suriname. Suriname is a society composed of many ethnic groups, such as Creoles, Maroons, Hindustani, Javanese, Chinese, Caucasians, and indigenous Amerindians. We estimated determinants for chlamydia, including the role of ethnicity, and identified transmission patterns and ethnic sexual networks among clients of two clinics in Paramaribo, Suriname.MethodsParticipants were recruited at two sites a sexually transmitted infections (STI) clinic and a family planning (FP) clinic in Paramaribo. Urine samples from men and nurse-collected vaginal swabs were obtained for nucleic acid amplification testing. Logistic regression analysis was used to identify determinants of chlamydia. Multilocus sequence typing (MLST) was performed to genotype C. trachomatis. To identify transmission patterns and sexual networks, a minimum spanning tree was created, using full MLST profiles. Clusters in the minimum spanning tree were compared for ethnic composition.ResultsBetween March 2008 and July 2010, 415 men and 274 women were included at the STI clinic and 819 women at the FP clinic. Overall chlamydia prevalence was 15% (224/1508). Age, ethnicity, and recruitment site were significantly associated with chlamydia in multivariable analysis. Participants of Creole and Javanese ethnicity were more frequently infected with urogenital chlamydia. Although sexual mixing with other ethnic groups did differ significantly per ethnicity, this mixing was not independently significantly associated with chlamydia. We typed 170 C. trachomatis-positive samples (76%) and identified three large C. trachomatis clusters. Although the proportion from various ethnic groups differed significantly between the clusters (P = 0.003), all five major ethnic groups were represented in all three clusters.ConclusionChlamydia prevalence in Suriname is high and targeted prevention measures are required. Although ethnic sexual mixing differed between ethnic groups, differences in prevalence between ethnic groups could not be explained by sexual mixing.

show abstract

“…One possible reason for the apparent smaller increase in seropositivity in women with two or more infections using the MOMP peptide ELISAs is that women may have been reinfected with a different serovar containing MOMP epitopes to which they had not been exposed in the original infection 20 21. There is some evidence that MOMP peptide assays may not have the same sensitivity for detecting antibody to all serovars,22 and we have recently demonstrated that while Medac and SeroCT assays have similar sensitivities in a community setting, some seropositive individuals are only detected by a single assay 23. We also observed an apparent greater probability of detecting chlamydia antibody with all assays for women attending Bristol GUM compared with St Mary's GUM departments.…”

Section: Discussionmentioning

confidence: 99%

Effect of time since exposure toChlamydia trachomatison chlamydia antibody detection in women: a cross-sectional study

et al. 2013

View full text Add to dashboard Cite

show abstract

Serological reactivity and bacterial genotypes in Chlamydia trachomatis urogenital infections in Guadeloupe, French West Indies

Abstract: The prevalence found in Guadeloupe did not differ significantly from that found in mainland France. The genotypes Da, F, I and Ia were more prevalent in Guadeloupe; however, the SERO-CT assay was unable to detect serum antibodies in 80% of the patients infected with genotype Ia strains.

Cited by 10 publications

References 28 publications

Chlamydia trachomatis infection prevalence and serovar distribution in a high-density urban area in the north of Italy

Chlamydia trachomatis infection prevalence and serovar distribution in a high-density urban area in the north of Italy

Urogenital Chlamydia trachomatis Infections among Ethnic Groups in Paramaribo, Suriname; Determinants and Ethnic Sexual Mixing Patterns

Effect of time since exposure toChlamydia trachomatison chlamydia antibody detection in women: a cross-sectional study

Contact Info

Product

Resources

About