Serological Overlap Between Lupus Erythematosus, Rheumatoid Arthritis, and Thyroid Auto-immune Disease

Hijmans, W.; Doniach, Deborah; Roitt, Ivan M.; Holborow, E. J.

doi:10.1136/bmj.2.5257.909

Cited by 173 publications

(78 citation statements)

References 30 publications

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“…Prevalence of SLE in study population was 12.5% and highest prevalence was seen in age group 20-30 years (77.78%). Prevalence in female was 12% as compared to male 1%, which is well in coherence with other studies conducted in past [10] Serological overlap among SLE, and AITD exists [11][12][13][14] that might be the reason for their association.…”

Section: Introductionsupporting

confidence: 78%

Prevalence of Musculoskeletal Manifestations among Primary Hypothyroid Patient in North India

Singh¹

2018

jmscr

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Section: Introductionsupporting

confidence: 78%

Prevalence of Musculoskeletal Manifestations among Primary Hypothyroid Patient in North India

Singh¹

2018

jmscr

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“…SLE has been reported not only in relation to hypoparathyroidism but also with other autoimmune diseases such as Sjogren's syndrome, rheumatoid arthritis, autoimmune thrombocytopenia, anti-phospholipid syndrome, hyperthyroidism, hypothyroidism, lymphocytic hypophysitis, polymyositis, myasthenia gravis, celiac disease, fibrosing alveolitis, juvenile chronic arthritis, and chronic active hepatitis (13). The prevalence of hypo-/hyperthyroidism was between 3.9 and 24% in patients with SLE and the frequency of antithyroid antibodies was between 11 and 51% (14)(15)(16). On the other hand, rare associations of hyperthyroidism with idiopathic hypoparathyroidism and hypocalcemia were advocated by some authors (17).…”

mentioning

confidence: 99%

Graves' Disease, Hypoparathyroidism, Systemic Lupus Erythematosus, Alopecia, and Angioedema: Autoimmune Polyglandular Syndrome Variant or Coincidence?

Melcescu

Kemp

Majithia

et al. 2013

Int J Immunopathol Pharmacol

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Data on coexisting Graves' disease (GD), hypoparathyroidism, and systemic lupus erythematosus (SLE) are limited. The thyroid and parathyroid glands may be extra sensitive to irradiation damage in an underlying autoimmune condition. A 34-year-old black woman presented with tetanic-like cramps, easy skin bruising, fatigue, weight gain, nocturia and back pain. She was previously diagnosed with GD in 2001 and underwent radioiodine therapy (RAI) in 9/01 using 6 mCi. PostRAI (November 2001) she developed hypocalcemia and hypothyroidism (2/02). In 2007, SLE was diagnosed. In October 2009, s-calcium and PTH were still low at 7.1 mg/dl and 9 pg/mL, respectively, although the patient denied symptoms on vitamin D and calcium supplementation. To identify possible autoimmune damage of the parathyroids, we evaluated the presence of activating antibodies to the CaSR and also analyzed the DNA sequence of all 6 translated exons and flanking intronic sequences of her CaSR gene for a functionally significant CaSR mutation but neither was positive. The initial autoimmune damage to her thyroid and possibly parathyroid glands followed by irradiation of them seems to have contributed to her developing both hypoparathyroidism (11/01) and hypothyroidism (2002). The patient could potentially have had parathyroid autoantibodies in 2001 that disappeared by 2009 when she was tested for them. We consider that the multiple autoimmune conditions developed over the past decade of her life with the concurrent irradiation contributing to her brittle hypoparathyroidism. Select patients with GD and perhaps parathyroid autoantibodies with a slowly developing destructive impact on the parathyroid glands may then develop overt hyoparathyroidism with rather low dose RAI ablation. This patient adds to the evolving spectrum of polyglandular syndrome variants.Here, we report a patient presenting with an interesting sequential combination of Graves' disease (GD), hypoparathyroidism, alopecia, and systemic lupus erythematosus (SLE). Hypocalcemia

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“…In the literature on associations between RA and hypothyroidism, which goes back to the 1960s 7,8 , one of the first studies reported thyroiditis in up to 12% of patients with RA 9 . Major limitations of these studies were cross-sectional or observational designs and lack of "adequate" control groups.…”

mentioning

confidence: 99%

Hypothyroidism in Rheumatoid Arthritis — To Screen or Not to Screen?

Raterman

Nurmohamed

2012

J Rheumatol

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Serological Overlap Between Lupus Erythematosus, Rheumatoid Arthritis, and Thyroid Auto-immune Disease

Cited by 173 publications

References 30 publications

Prevalence of Musculoskeletal Manifestations among Primary Hypothyroid Patient in North India

Prevalence of Musculoskeletal Manifestations among Primary Hypothyroid Patient in North India

Graves' Disease, Hypoparathyroidism, Systemic Lupus Erythematosus, Alopecia, and Angioedema: Autoimmune Polyglandular Syndrome Variant or Coincidence?

Hypothyroidism in Rheumatoid Arthritis — To Screen or Not to Screen?

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