Serological Monitoring Is Key To Sustain Progress of the Maternal and Neonatal Tetanus Elimination Initiative

Levine, Myron M.; Pasetti, Marcela F.

doi:10.1128/cvi.00259-16

Cited by 5 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Periodic monitoring of the proportion of sero-protection against tetanus is a critical tool to document the elimination of maternal and neonatal tetanus [ 10 11 ]. In spite of the global effort to achieve eliminating maternal and neonatal tetanus (75% of 29 priority countries validated achieving elimination targets in 2018), approximately 47-million women and neonates are not protected against tetanus globally, with low vaccination coverage due to the lack of access to health services, limited healthcare systems, lack of security, social conflict, lack of funding, among others [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Successful seroconversion against diphtheria and tetanus induced through maternal vaccination in a region of Colombia

Hincapié-Palacio

Echeverri

Hoyos

et al. 2022

Clin Exp Vaccine Res

View full text Add to dashboard Cite

Purpose This study aims to compare protection against diphtheria and tetanus conferred on the mother and the neonate before and after maternal vaccination against tetanus, diphtheria, and acellular pertussis (Tdap), transfer of antibodies, and the variables that could impact on the protection. Materials and Methods The study followed a cohort of 200 pregnant women from a region in Colombia, contacted during prenatal control before vaccination and upon delivery. The work determined immunoglobulin G antibodies against diphtheria and tetanus of pregnant women and umbilical cord. The proportion of protection, the geometric mean of the concentration, and the transfer of maternal antibodies were calculated. The protection profile of the pregnant women was explored by using multiple correspondence analysis. Results The concentration of antibodies against diphtheria was significant before and after vaccination of the pregnant women (p=0.000) with proportions of 85.0% and 97.5%, respectively, and of 98.6% in the umbilical cord, with significant antibody correlation (Spearman’s coefficient=0.668, p=0.01). Sero-protection against tetanus before vaccination was at 71.0%, after at 92.6%, and in the umbilical cord at 95.9%, with significant antibody concentration before and after vaccination (p=0.000) and antibody correlation (Spearman’s coefficient=0.936, p=0.01). Sero-protection was higher when the pregnant women were vaccine 8 to 11 weeks before delivery. Unprotected pregnant women were those not vaccinated during pregnancy. Conclusion The high proportion of protection against diphtheria and tetanus and the placental transfer support the need to promote maternal immunization with Tdap.

show abstract

Section: Introductionmentioning

confidence: 99%