Serological markers of inflammatory bowel disease in children from the Western region of Saudi Arabia

Saadah, Omar I.; Al-Mughales, Jamil A.

doi:10.1016/j.ajg.2013.05.004

Cited by 2 publications

(9 citation statements)

References 34 publications

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“…This, therefore, translate into 60% of our UC cohort tested positive for pANCA or Atypical ANCA. In comparing our results with those in previous literature particularly Arab children in Saudi children, which showed a 28% frequency of pANCA [ 22 ], the frequency of pANCA and atypical ANCA is high in our cohort. To the best of our knowledge there are no other reports from Arab population in the Arab World.…”

Section: Discussionsupporting

confidence: 79%

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ASCA and ANCA among Bedouin Arabs with inflammatory bowel disease, the frequency and phenotype correlation

et al. 2018

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BackgroundSerological markers used for diagnostic purposes and disease stratification in inflammatory bowel disease.We aimed to investigate the frequency of ASCA and ANCA among Arab Bedouin IBD patients and its relationship to disease phenotype and course.MethodsFrom cohort of 68, 25 Crohn’s disease (CD) and 25 Ulcerative colitis (UC) patients were recruited (72%). ASCA IgG was determined by ELISA assay. Immunofluorescence analysis of ANCA was performed.ResultsThe IgG ASCA was detected in 13 (52%) of the CD patients and in three (12%) UC patients. The prevalence of ANCA among UC patients was positive with 76%, sub-grouped, atypical ANCA in 9 patients (36%), pANCA in six patients (24%) and cANCA in 4 patients (16%).The detection of ASCA among CD patients was found not to be a reliable predictor of young age at diagnosis, gender, ileal involvement, anti-TNF treatment or surgery.UC patients with positive ANCA were younger, mean age 40.2 ± 11.9 compared with 57.3 ± 21.2 (p = 0.03), and diagnosed at a younger age, 29.2 ± 11.8 compared with 43.5 ± 15.3 (p = 0.05).ConclusionThe frequency of ASCA among Bedouin CD patients and ANCA among UC patients was high, however ASCA was not found to have a predictive value for disease phenotype or course. Positive ANCA in UC patients was predictive for younger age and age at diagnosis.

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Section: Discussionsupporting

confidence: 79%

“…There are only few reports in the Arab world regarding serological markers in IBD among the Arab population; a study of IBD in children from Saudi Arabia found a prevalence of 35% of ASCA in CD patients and 28% of pANCA in UC [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

ASCA and ANCA among Bedouin Arabs with inflammatory bowel disease, the frequency and phenotype correlation

et al. 2018

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“…In that group, ages 14±4.6 years (range 1. [6][7][8][9][10][11][12][13][14][15][16][17][18]. We also evaluated 25 patients with a confirmed diagnosis of UC, 11 males (UC group).…”

Section: Resultsmentioning

confidence: 99%

“…The classic biomarkers p-ANCA and ASCA help in the differential diagnosis between pediatric CD and UC, in the prognosis in CD, in the clinical expression of UC, and more recently its corrections with early treatment with anti-TNF, in addition to the association with the variability of the intestinal microbiome and the damage of the intestinal mucosa, justifying the interest in this subject in the present day (7)(8)(12)(13)(14)(15)(16)(17) .…”

Section: Discussionmentioning

confidence: 99%

“…Our study founded the accuracy of p-ANCA testing for the detection of UC with a sensitivity of 64%, specificity of 100%, and negative predictive value of 84.2%. In pediatric IBD, sensitivity/specificity of p-ANCA in UC range between 28.9% to 83% and 65% to 94.2%, respectively (6,(12)(13)(14)(15)18,24,25) . Although p-ANCA was present in almost all our pediatric patients with UC, it was also positive around one-third of our CD patients as in others studies, and absent in all our control groups, in contrast with the results from others studies (6,12,14,20) .…”

Section: Discussionmentioning

confidence: 99%

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Classical Serological Markers in Pediatric Inflammatory Bowel Disease in Brazil

Rodrigues

Bueno

Lomazi

et al. 2021

Arq. Gastroenterol.

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BACKGROUND: Perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) and anti-Saccharomyces cerevisiae antibodies (ASCAs) have long been used to differentiate between Crohn’s disease (CD) and ulcerative colitis (UC), more recently having been used as prognostic indicators. OBJECTIVE: To determine the diagnostic accuracy of serological markers in the identification of pediatric CD and UC in Sao Paulo, Brazil, as well as to correlate those markers with characteristics demographic and clinical of these two diseases. METHODS: Retrospective cross-sectional multi-center study involving pediatric patients with inflammatory bowel disease (IBD). We identified ASCAs serological markers and p-ANCA, correlating their presence with demographic and clinical data, not only in the patients with IBD but also in a group of age-matched gastrointestinal disease-free controls. RESULTS: A total of 122 patients, 74 with IBD (46% males), treated at four pediatric gastroenterology referral centers, the mean age of 13±7 years, 49 (66%) with CD, and 25 (34%) with UC. The control Group comprised 48 patients (54% males). The proportion of patients testing positive for p-ANCA was significantly higher in the UC group (69.9%) compared to the CD group (30.4%), as well as being significantly higher in the CD group versus the control Group (P<0.001 for both). The proportion of patients testing positive for ASCA IgA (76.2%) and ASCA IgG (94.4%) markers was also significantly higher in the CD group than in the control Group (P<0.001), and such positivity correlated significantly with the use of immunomodulatory medications such as azathioprine and anti-tumor necrosis factor agents (azathioprine 38.9%, anti-TNF 55.6%; P=0.002). In the CD group, the proportion of patients testing positive for the ASCA IgA was significantly higher among those who underwent surgery than among those who did not (26.86±17.99; P=0.032). CONCLUSION: In pediatric patients with IBD in Sao Paulo, Brazil, serological tests proving to be highly specific, although not very sensitive, for the diagnosis of IBD. However, the serological markers showed a positive correlation with the severity of the disease.

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Serological markers of inflammatory bowel disease in children from the Western region of Saudi Arabia

Cited by 2 publications

References 34 publications

ASCA and ANCA among Bedouin Arabs with inflammatory bowel disease, the frequency and phenotype correlation

ASCA and ANCA among Bedouin Arabs with inflammatory bowel disease, the frequency and phenotype correlation

Classical Serological Markers in Pediatric Inflammatory Bowel Disease in Brazil

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