Serological investigation of bullous scabies and review of the published work

Kokubu, Hiraku; Takahashi, Tamiko; Tateishi, Chiharu; Tsuruta, Daisuke; Hashimoto, Takashi; Tanaka, Toshihiro; Fujimoto, Noriki

doi:10.1111/1346-8138.14883

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…Sarcoptes scabiei mites are thought to produce certain enzymes and bullous pemphigoid-like antigens, a phenomenon of antigen mimicry, that induce BMZ antibodies formation, causing complement cascade activation, dermo-epidermal separation and BMZ lytic destruction. The presence of mites within the bullae could support this hypothesis (Kokubu et al 2019 ).…”

Section: Histopathological Changes In Scabiesmentioning

confidence: 80%

Scabies: Immunopathogenesis and pathological changes

Sharaf

2024

Parasitol Res

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Scabies is an itchy skin disease caused by the burrowing mite Sarcoptes scabiei. During their lifespan, the female mites invade the stratum corneum and create tunnels, in which they reside, move, feed, deposit fecal pellets, and lay eggs. Recently, scabies was included in the World Health Organization roadmap for neglected tropical diseases 2021–2030. This review attempts to summarize our knowledge about the mite’s biology and the disease pathogenesis, pathological changes, and complications. Generally, the host–parasite interaction in scabies is highly complex and involves different mechanisms, some of which are yet largely unknown. Elucidation of the nature of such interaction as well as the underlying mechanisms could allow a better understanding of the mite’s biology and the development of novel diagnostic and therapeutic options for scabies control programs. Moreover, identification of the molecular basis of such interaction could unveil novel targets for acaricidal agents and vaccines.

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Section: Histopathological Changes In Scabiesmentioning

confidence: 80%

Scabies: Immunopathogenesis and pathological changes

Sharaf

2024

Parasitol Res

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“…Bullous scabies and BP share many similar characteristics, such as prevalence in the elderly, tense blisters containing clear fluid, negative Nikolsky's sign, and subepidermal blister formation with a mixed inflammatory infiltrate predominantly consisting of neutrophils and eosinophils as well as linear depositions of IgG in some patients. 5,9,10 However, many clinical characteristics indicate a higher likelihood of BS. The presence of several skin lesions (e.g., papules, papulovesicles, scales, and blisters) mainly distributed in skin folds or delicate skin areas (e.g., finger web spaces, thigh, abdomen, and male genitalia), pruritus that worsened at night, younger patient ages, poor response to corticosteroid, and similar itchy lesions in the patients' families or friends were indicative of BS.…”

Section: Discussionmentioning

confidence: 99%

Bullous Scabies: Clinical, Dermoscopic, and Pathologic Characteristics of Ten Patients

Jia

Chen

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Bullous scabies (BS) is a rare atypical clinical variant of scabies and is easily confused with bullous disorders. The diagnosis of BS is always a challenge, and physicians often misdiagnose BS patients. Patients with BS admitted from 2012 to 2020 were enrolled in this study. The clinical, dermoscopic, and pathological characteristics of the patients were analyzed retrospectively. Ten patients with BS were enrolled in this study. Seven of the 10 patients were male. The bullae were most commonly found on the thighs and arms (80% of patients). Only 30% of patients (3/10) tested positive for mites and/or eggs by the initial skin scraping, but 100% (5/5) of the patients who received dermoscopy tested positive. Among these 10 patients, only five received a skin biopsy. Subepidermal (4/5) and intraepidermal (1/5) bullae with eosinophil and neutrophil infiltration were observed in five patients. Direct immunofluorescence (DIF) indicated linear deposition of IgG in the basement membrane zone in three patients. Physicians should consider the possibility of BS in patients with blisters, pruritus, and poor response to corticosteroids. Dermoscopy should be prioritized for the differential diagnosis of BS to exclude other bullous disorders. Finally, a biopsy should be performed on each patient with bullae.

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“…Mites have been found within the blister cavity hence supporting this hypothesis.Autoantibody formation can also be explained by the phenomenon of antigen mimicry that is cross reactivity between mite antigens and the BMZ antigens that leads to production of BP antibodies 25 . Few cases in literature have demonstrated the presence of antibodies against BP180 or BP230 in patients with bullous scabies, thereby supporting this theory 27,28 . An id reaction to scabies mite, called as scabid, can occur leading to bulla formation 29 …”

Section: Bullous Scabiesmentioning

confidence: 98%

“…25 Few cases in literature have demonstrated the presence of antibodies against BP180 or BP230 in patients with bullous scabies, thereby supporting this theory. 27,28 An id reaction to scabies mite, called as scabid, can occur leading to bulla formation. 29 iii.…”

Section: Bullous Scabiesmentioning

confidence: 99%

Scabies: A comprehensive review and current perspectives

Arora

Rudnicka

Sar‐Pomian

et al. 2020

Dermatologic Therapy

114

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Human scabies is a contagious skin infestation caused by the parasitic mite Sarcoptes scabiei var. hominis. It is a common skin disease worldwide that occurs not only in the underprivileged sections of society but also in developed countries. In 2009, World Health Organization (WHO) recognized scabies as “neglected tropical disease (NTD)” or NTD thus emphasizing the need for community awareness and proper treatment strategies. This review attempts to summarize the varied clinical presentation of the disease and describes the advances in diagnosis and management including the ongoing search for novel agents to overcome the problems associated with conventional treatments. The literature research includes peer‐reviewed articles (clinical trials or scientific reviews). Studies were identified by searching electronic databases (MEDLINE and PubMed) till February 2020 and reference lists of respective articles. Only articles published in English language were included.

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Serological investigation of bullous scabies and review of the published work

Cited by 5 publications

References 5 publications

Scabies: Immunopathogenesis and pathological changes

Scabies: Immunopathogenesis and pathological changes

Bullous Scabies: Clinical, Dermoscopic, and Pathologic Characteristics of Ten Patients

Scabies: A comprehensive review and current perspectives

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