Serological hepatitis A virus infections and ratio of clinical to serological infections in a controlled trial of pre-exposure prophylaxis with immune serum globulin.

Kark, Jeremy D.; Bar-Shany, S; Shor, Samuel; Merlinski, L; Nili, E

doi:10.1136/jech.39.2.117

Cited by 3 publications

(2 citation statements)

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“…These rates are obviously influenced by a v a r i e t y of climatic and sociohygienic factors, including the effectiveness of immunoglobulin prophylaxis. A ntlmber of serial cross-sectional studies carried out in areas in which hepatitis A is endemic have revealed that the annual increment of anti--HAV positives varied from lto 3% (10,12). though occasionally it can be as high as 35% (16).…”

Section: Introductionmentioning

confidence: 99%

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Shifts in the rates and levels of antibody to hepatitis A virus associated with hepatitis A infection in children's communities

Prikazchikov

Balayan

1987

Eur J Epidemiol

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In order to investigate the shift in the rates and levels of antibody to hepatitis A virus, 567 children in 20 isolated groups of five day-care centers were observed over a period of 8 months during which the seasonal rise in hepatitis A morbidity occurs. Increases in the proportion of seropositive ranging from 5 to 37% were demonstrated in 6 groups, and were always associated with the occurrence of either overt or sub-clinical hepatitis A infection. High rates of seropositivity were also noted in the groups in which cases of hepatitis A had been registered prior to the period of observation. In some children with low and medium antibody levels, antibody titres showed further increases after reinfection. A substantial part of children retained low antibody titres during the entire period of observation, and eight previously sero-negative children developed low antibody levels after asymptomatic hepatitis A infections. In one group the spread of hepatitis A infection (clinical and asymptomatic) was prevented by the administration of commercially available immunoglobulin immediately after the discovery of an infected food handler. Passive antibodies were found in previously sero-negative children, and these antibodies dropped to undetectable levels two months after administration.

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Section: Introductionmentioning

confidence: 99%

“…The efficacy of immunoglobulin in preventing hepatitis A infection, either overt (7, 6 ) o r s u bclinical (12), has been repeatedly demonstrated.…”

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confidence: 99%