Serological evidence of spotted fever group rickettsiosis in and around Puducherry, south India—A three years study

Spellman, Stephen R.; Ambroise, Stanley; Gunasekaran, Dhandapany; Hanifah, Mohamed; Sangeetha, Balakrishnan; Pradeep, Jothimani; Sarangapani, Kengamuthu

doi:10.4103/0972-9062.242562

Cited by 18 publications

(15 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The common symptoms in their study (excluding fever) were rashes (exanthema) and lymphadenopathy. 41 The same results were found in our study. The obtained data also overlap with the data of other studies performed in India, where the seroprevalence of antibodies to SFG rickettsiae 44 In our study, the occurrence for TG rickettsiae was 2.7% and comparable to investigations in other countries.…”

Section: Discussionsupporting

confidence: 91%

Occurrence of Anti-Rickettsia spp. Antibodies in Hospitalized Patients with Undifferentiated Febrile Illness in the Southern Region of Kazakhstan

Turebekov¹,

Abdiyeva²,

Yegemberdiyeva

et al. 2021

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract.Undifferentiated febrile illness still represents a demanding medical problem all over the world, but primarily in low- and middle-income countries. Scientific and clinical investigations related to undifferentiated febrile illness and rickettsial diseases in Kazakhstan are lacking. This study reflects the investigation of antibodies against spotted fever group (SFG) and typhus group (TG) rickettsiae in patients with undifferentiated febrile illness in the southern region of Kazakhstan (Almaty and Kyzylorda oblasts). Paired serum samples were gathered from 13 hospitals in these two oblasts and explored for the presence of IgM and IgG antibodies against typhus group and IgG antibodies against spotted fever group rickettsiae using ELISA. Patient’s questionnaires were statistically analyzed. In total, 802 inpatients from Almaty (N = 9) and Kyzylorda (N = 4) hospitals were included in this research. Based on ELISA results, 250 patients out of 802 (31.2%) from both oblasts had IgG antibodies against SFG rickettsiae. Results from 11 (1.4%) patients indicated acute infection with tick-borne rickettsiosis. Regarding TG rickettsiae (R. typhi), a past infection was detected in 248 (30.9%) febrile patients and acute infection in 22 (2.7%) patients in the two selected oblasts. The data indicated that SFG and TG rickettsioses are present in Kazakhstan. Kazakh physicians should be aware of these emerging diseases in both investigated oblasts because the occurrence of these diseases is not suspected during day-to-day clinical practice. The identification of rickettsial pathogens and implementation of modern laboratory methods for the diagnostics of rickettsioses are in need throughout Kazakhstan.

show abstract

Section: Discussionsupporting

confidence: 91%

Occurrence of Anti-Rickettsia spp. Antibodies in Hospitalized Patients with Undifferentiated Febrile Illness in the Southern Region of Kazakhstan

Turebekov¹,

Abdiyeva²,

Yegemberdiyeva

et al. 2021

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…Among the pediatric population, AFI due to RD occurred in 0.4 to 7.4% in East Africa, 2 to 17% in South Asia, 0.5 to 20.1% in SE Asia, and 7.5% in Latin America [4]. There is increasing serological evidence for RD in various parts of India [5] and molecular evidence of new rickettsial species in AFI cases [6,7].…”

Section: Introductionmentioning

confidence: 99%

Rickettsial Diseases: Not Uncommon Causes of Acute Febrile Illness in India

et al. 2020

View full text Add to dashboard Cite

Rickettsial diseases (RDs) are major under-diagnosed causes of arthropod borne acute febrile illness (AFI) presenting with a range of symptoms from mild self-limiting fever to fatal sepsis. The spotted fever group (SFG) and typhus group (TG) are major RDs, which are commonly caused by Rickettsia conorii and Rickettsia typhi, respectively. The limited availability and role of serological tests in the acute phase of illness warrants rapid reliable molecular methods for diagnosis and epidemiological studies. Two hundred patients with AFI in whom the routine fever diagnostics were negative, were enrolled over a period of two months (April 2019 to May 2019). DNA was extracted and in-house nested PCR using primers specific for both SPG and TG pathogens was used. The positive amplified products were sequenced for species identification and phylogenetic analysis was performed using MEGA 7.0.14 software (iGEM, Temple University, Philadelphia, PA 19122, USA). The demographic details of the RD cases were documented. The prevalence of RD among AFI cases was 7% (14/200); SFG and TG were identified as the cause in 4% and 3% of AFI cases, respectively. The median age of the RD cases was 22 years (range 2-65). The median duration of fever was 3 days (range 1-12). The RD cases presented with respiratory symptoms or signs (44.44%), jaundice (22.22%), abdominal pain (22.22%), diarrhea (22.22), vesicular rash (11.11%), vomiting (11.11%), loss of appetite (11.11%), headache (11.11%), leukocytosis (88.88% with mean count 22,750/mm 3 ), and thrombocytopenia (33.33%). The cases were treated empirically with piperacillin-tazobactam (66.66%), clindamycin (44.44%), cefotaxime (33.33%), meropenem (33.33%), metronidazole (33.33%), doxycycline (22.22%), azithromycin (22.22%), ceftriaxone (11.11%), and amoxicillin-clavulanic acid (11.11%). The mortality among the RD cases was 11.11%. The present pilot study shows that RD is not an uncommon cause of AFI in north India. The febrile episodes are usually transient, not severe and associated with heterogenous clinical presentation without documented history of tick exposure in the hospitalized patients. The transient, non-severe, febrile illness could be due to transient rickettsemia resulting from empirical antimicrobial therapy as the rickettsial organisms are expected to be more susceptible to higher doses of β-lactam antibiotics. The study emphasizes the molecular method as a useful tool to identify rickettsial etiology in AFI.

show abstract

“…which are responsible for viral diseases of Crimean-Congo haemorrhagic fever and Kyasanur forest disease (Mourya et al 2014). The epidemic of Indian tick typhus was reported from Himachal Pradesh (Kumar et al 2011) and serologically positive cases of Lyme disease and rickettsiosis were reported from Tamil Nadu and Pondicherry (Sharma et al 1992;Stephen et al 2018). The first instance of Crimean-Congo haemorrhagic fever was detected from Gujarat (Kumar et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Distribution and prevalence of ticks on livestock population in endemic area of Kyasanur forest disease in Western Ghats of Kerala, South India

et al. 2019

View full text Add to dashboard Cite

Tick borne zoonotic diseases are one of the major emerging threats to live stock and public health in India, especially in Western Ghats of south India. Since livestock and wild animals share habitats and grasslands, it is important to know the species composition of major tick parasitism on live stock as well as their geographical distribution for effective control of tick and tick borne diseases. This study provides basic knowledge that is necessary to initiate Kyasanur Forest Disease (KFD) prevention programs in these areas. Ticks were sampled from Wayanad districts of Kerala from domestic animals and identified morphologically. A total of 195 cattle searched, in which 168 (86.15%) cattle were infested with ticks and a total of 3633 ticks comprising three genera and seven species were collected, Rhipicephalus microplus (52.71%) was prevalent species followed by Haemaphysalis bispinosa (16.9%), Rhipicephalus decoloratus (15.77%), Haemaphysalis turturis (11.42%), Rhipicephalus sanguineus (1.32%), Amblyomma integrum (1.15%) and Haemaphysalis spinigera (0.71%) were identified based on their morphological characters. As R. microplus was the prevalent species, the risk of transmission of babesiosis and anaplasmosis to cattle increases and the presence of Haemaphysalis sp. point out the risk of KFD in among the tribal colony people and it can be reduced by applying with acaricides on domestic animals.

show abstract

Serological evidence of spotted fever group rickettsiosis in and around Puducherry, south India—A three years study

Cited by 18 publications

References 1 publication

Occurrence of Anti-Rickettsia spp. Antibodies in Hospitalized Patients with Undifferentiated Febrile Illness in the Southern Region of Kazakhstan

Occurrence of Anti-Rickettsia spp. Antibodies in Hospitalized Patients with Undifferentiated Febrile Illness in the Southern Region of Kazakhstan

Rickettsial Diseases: Not Uncommon Causes of Acute Febrile Illness in India

Distribution and prevalence of ticks on livestock population in endemic area of Kyasanur forest disease in Western Ghats of Kerala, South India

Contact Info

Product

Resources

About