Serological Classification of Neisseria Gonorrhoeae. Serovars Associated with Homosexually Acquired Infection

Coghill, D.V.; Gaitonde, R.; Kelly, George E; Young, H

doi:10.1007/978-94-009-1383-7_12

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…In previous years serovar Back/Bropyt has correlated strongly with homosexually acquired infection and from November 1985 to June 1986 accounted for 69 %/ of homosexually acquired infection [6]. The drop in the number of cases in 1987 was presumably as a result of safer sexual practices following widespread health education messages encouraging 'safe sex ' as a response to the threat of H1IV infection.…”

Section: Resultsmentioning

confidence: 99%

“…It is possible that the increased isolation rate of Bacejk/Brpyut and Bacejk/Brpyust in 1990 may reflect such changes. The natural history of isolation rates for individual serovars is to vary from year to year however [6] and the factors responsible for these variations are not known. A large influx of new strains may explain a localized rise in the incidence of gonorrhoea and the proportion of infections due to minor serovars did increase in 1990.…”

Section: Resultsmentioning

confidence: 99%

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Changing trends of gonococcal infection in homosexual men in Edinburgh

1991

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SUMMARYIn an attempt to explain the recent resurgence of homosexually-acquired gonorrhoea in the Lothian region of Scotland the number of infections and pattern of infection (urethral, rectal and pharyngeal) of all gonococcal isolates from homosexual men attending the Department of Genitourinary Medicine at Edinburgh Royal Infirmary between 1985 and 1990 were analysed. Serovar typing data were available from infections acquired between January 1986 and December 1990. A correlation between one serovar, Bacejk/Brpyust, and the overall pattern of gonorrhoea was observed. The number of infections caused by minor serovars also correlated with rates of gonococcal infection. The number of minor serovars isolated, which may represent strains from other geographical locations, is related to the total incidence of gonorrhoea. It is possible that the incidence of Bacejk/Brpyust may be determined by the size of the infected pool of gonorrhoea. The most likely explanation for the recent increase in gonorrhoea is a change in sexual behaviour and/or an influx of strains from other geographical areas.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Changing trends of gonococcal infection in homosexual men in Edinburgh

1991

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“…auxotyping. The epidemiological applications include identifying associations between sexual orientation and serovar (4,18) and between site of infection and serovar (5). Certain serovars (1B-5/7 [8,16]) are associated with I Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Serotype patterns of gonococcal infection in contact pairs

et al. 1993

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The use of gonococcal serovars in studying the epidemiology of Neisseria gonorrhoeae is well established. Most studies assume that the isolated serovar remains stable in vivo indefinitely. This study was designed to observe the correlation between serovars isolated in patients naming each other as sexual contacts. The overall rate of discordant transmission episodes was 12% (26/220). There were however significantly more discordant transmission episodes for partners of patients infected with IB serovars than IA serovars: 19% (23/124) versus 3% (3/96) - p < 0.01. The overall prevalence of serogroup IB isolates although significantly higher at 53% (p < 0.01) was thought insufficient to account for the correlation between discordant pairs and serogroup IB infection. Reasons considered for the discrepancies in contact pairs included: problems of partner reporting involving inaccurate or incomplete information; technical problems with reagents; culture induced phenotypic variation in antigenic expression or differences in the in vitro recognition of epitopes; and antigenic differences resulting from genetic mutation within the Protein I gene. It was concluded that carefully planned and controlled prospective studies involving duplicate parallel testing of isolates from patients and their well documented partners are needed to assess the extent to which these various factors contribute to discordancies in serovars isolated from contact pairs. Serotyping should be combined with other methods such as auxotyping for detailed microepidemiological studies involving partner notification.

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Epidemiological typing of neisseria gonorrhoeae: A comparative analysis of three monoclonal antibody serotyping panels

Moyes

Young

1991

Eur J Epidemiol

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Sixteen hundred and thirty seven isolates of Neisseria gonorrhoeae isolated over a two year period were serotyped using three panels of monoclonal antibodies. The isolates comprised 687 serogroup WI strains and 950 serogroup WII/III strains. The antibodies used in the panels were those developed by Pharmacia (Ph) and Genetic Systems (GS). The GS antibodies were used as two separate panels; the American (GS-A) panel which designates serovars by a simple numerical nomenclature and the Swedish (GS-S) panel which designates serovars by a more detailed descriptive nomenclature. Using only a single panel the Ph panel gave the greatest discrimination yielding 42 serovars compared with 28 serovars with the GS-S panel and 23 serovars with the GS-A panel. Using two panels in combination, the GS-A/Ph panel combination gave the greatest discrimination with 81 serovar combinations while a combination of the GS-S and Ph panels yielded 77 serovar combinations. A compilation of antibodies from all three panels yielded 90 serovar combinations. As the combination of GS-A and Ph panels gave a greater degree of discrimination than the combination of the GS-S and Ph panels we advocate that first-stage serotyping should be performed with the more widely used GS-A panel while second-stage serotyping should be performed with the Ph panel. We propose that serovar combinations should be reported using a dual nomenclature e.g. IA-1/Arost, IB-1/Bropt, IB-1/Bropyt etc. The use of such a dual system would allow "core comparison" between all centres while maintaining a degree of flexibility regarding the extent of discrimination required.

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Serological Classification of Neisseria Gonorrhoeae. Serovars Associated with Homosexually Acquired Infection

Cited by 5 publications

References 11 publications

Changing trends of gonococcal infection in homosexual men in Edinburgh

Changing trends of gonococcal infection in homosexual men in Edinburgh

Serotype patterns of gonococcal infection in contact pairs

Epidemiological typing of neisseria gonorrhoeae: A comparative analysis of three monoclonal antibody serotyping panels

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