Serologic evidence of exposure to influenza D virus among persons with occupational contact with cattle

White, Sarah K.; Ma, Wenjun; McDaniel, Clinton J.; Gray, Gregory C.; Lednicky, John A.

doi:10.1016/j.jcv.2016.05.017

Cited by 130 publications

(133 citation statements)

References 13 publications

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“…Inclusion of IDV into commercial BRD vaccines may improve their efficacy in preventing BRD. While several studies have failed to find evidence of widespread IDV infections in humans (Hause et al, 2013;Smith et al, 2016), a recent study found that 97% of humans occupationally exposed to cattle were serologically positive to IDV by microneutralization in contrast to 18% of non-exposed humans (White et al, 2016). While it is unknown whether infection of humans with IDV causes disease, vaccination of cattle could help limit zoonosis.…”

Section: Discussionmentioning

confidence: 99%

An inactivated influenza D virus vaccine partially protects cattle from respiratory disease caused by homologous challenge

Hause

Huntimer

Falkenberg

et al. 2017

Veterinary Microbiology

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Originally isolated from swine, the proposed influenza D virus has since been shown to be common in cattle. Inoculation of IDV to naïve calves resulted in mild respiratory disease histologically characterized by tracheitis. As several studies have associated the presence of IDV with acute bovine respiratory disease (BRD), we sought to investigate the efficacy of an inactivated IDV vaccine. Vaccinated calves seroconverted with hemagglutination inhibition titers 137-169 following two doses. Non-vaccinated calves challenged with a homologous virus exhibited signs of mild respiratory disease from days four to ten post challenge which was significantly different than negative controls at days five and nine post challenge. Peak viral shedding of approximately 5 TCID/mL was measured in nasal and tracheal swabs and bronchoalveolar lavage fluids four to six days post challenge. Viral titers were significantly (P<0.05) decreased 1.4 TCID/mL, 3.6 TCID/mL and 5.0 TCID/mL, respectively, in the aforementioned samples collected from vaccinated animals compared to non-vaccinated controls at peak shedding. Viral antigen was detected in the respiratory epithelium of the nasal turbinates and trachea by immunohistochemistry from all unvaccinated calves but in significantly fewer vaccinates. Inflammation characterized by neutrophils was observed in the nasal turbinate and trachea but not appreciably in lungs. Together these results support an etiologic role for IDV in BRD and demonstrate that partial protection is afforded by an inactivated vaccine.

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Section: Discussionmentioning

confidence: 99%

An inactivated influenza D virus vaccine partially protects cattle from respiratory disease caused by homologous challenge

Hause

Huntimer

Falkenberg

et al. 2017

Veterinary Microbiology

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“…Serologic assays in two independent studies showed that IDV could potentially infect humans, although seropositivity rates in the studies differed. One of the studies reported 91% seropositivity among 35 persons working with cattle (White et al, 2016), and the other reported only 1% seropositivity among 741 persons with suspected high exposure to IDV (Eckard, 2016). Nevertheless, epidemiologic, serologic, and pathologic studies have suggested cattle are the primary natural reservoir for IDV (Collin et al, 2015; Ducatez et al, 2015; Ferguson et al, 2015; Ferguson et al, 2016; Hause et al, 2014; Jiang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Serological evidence for high prevalence of Influenza D Viruses in Cattle, Nebraska, United States, 2003–2004

et al. 2017

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Influenza D virus (IDV), a new member of the influenza virus family, was first reported in 2011 in swine in Oklahoma, USA, and then soon found in cattle across North America and Eurasia. Earlier studies suggested cattle serve as natural reservoir for IDV. The goal of this study is to perform a retrospective study looking at sera collected from Nebraska beef herds in 2003–2004 and 2014 for evidence of IDV antibodies. Results showed that all 40 randomly selected farms (2003–2004) we tested contained IDV seropositive adult animals and that approximately 98% of newborn calves (2014) had high levels of maternal antibodies against IDV. This study suggested that IDV exposures were present in Nebraska beef cattle since at least 2003.

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“…To this day, it was found in swine but more frequently in cattle showing mild respiratory disease suggesting cattle may be the domestic reservoir species for IDV . No human cases were discovered thus far though antibodies for IDV were found in people with close contact to cattle and swine, and in vitro studies demonstrated the ability of the virus to grow in human‐derived cells …”

Section: Introductionmentioning

confidence: 99%

“…In the wake of the H1N1pdm/2009 human pandemic, European surveillance projects for swine IAV revealed that four main IAV lineages were in circulation in domestic swine populations in Europe, one of which was of avian and three of human origin . Very little is known concerning the occurrence of IBV, ICV and IDV in European swine populations and other animal hosts . In the light of the fact that most of the porcine IAV strains established in swine are of human origin, it is conceivable that this could also be possible for human IBV and ICV .…”

Section: Introductionmentioning

confidence: 99%

A newly developed tetraplex real‐time RT‐PCR for simultaneous screening of influenza virus types A, B, C and D

Henritzi

Hoffmann

Wacheck

et al. 2018

Influenza Resp Viruses

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BackgroundHuman‐ or avian‐to‐swine transmissions have founded several autonomously circulating influenza A virus (IAV) lineages in swine populations that cause economically important respiratory disease. Little is known on other human influenza virus types, like B (IBV) and C (ICV) in European swine, and of the recently detected novel animal influenza virus type D (IDV).ObjectivesDevelopment of a cost‐effective diagnostic tool for large‐scale surveillance programmes targeting all four influenza virus types.MethodsAn influenza ABCD tetraplex real‐time RT‐PCR (RT‐qPCR) was developed in the frame of this study. A selection of reference virus strains and more than 4000 porcine samples from a passive IAV surveillance programme in European swine with acute respiratory disease were examined.ResultsTwo IBV, a single IDV but no ICV infections were identified by tetraplex RT‐qPCR. IBV and IDV results were confirmed by conventional RT‐PCR and partial sequence analysis.ConclusionsThe tetraplex RT‐qPCR proved fit for purpose as a sensitive, specific and high‐throughput tool to study influenza virus transmission at the human‐animal interface. Complementing close‐meshed active virological and serological surveillance is required to better understand the true incidence and prevalence of influenza virus type B, C and D infections in swine.

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Serologic evidence of exposure to influenza D virus among persons with occupational contact with cattle

Cited by 130 publications

References 13 publications

An inactivated influenza D virus vaccine partially protects cattle from respiratory disease caused by homologous challenge

An inactivated influenza D virus vaccine partially protects cattle from respiratory disease caused by homologous challenge

Serological evidence for high prevalence of Influenza D Viruses in Cattle, Nebraska, United States, 2003–2004

A newly developed tetraplex real‐time RT‐PCR for simultaneous screening of influenza virus types A, B, C and D

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