Seroepidemiology of Human Papillomavirus Type 11 in the United States: Results From the Third National Health and Nutrition Examination Survey, 1991–1994

Hariri, Susan; Dunne, Eileen F.; Sternberg, Maya; Unger, Elizabeth R.; Meadows, Kristi S.; Karem, Kevin L.; Markowitz, Lauri E.

doi:10.1097/olq.0b013e31815abaef

Cited by 21 publications

(21 citation statements)

References 44 publications

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“…Behavioral factors associated with seropositivity in our study were similar to those reported elsewhere [15,16,39] and confirm data from prospective studies that lifetime number of sex partners is a strong predictor of HPV infection [8,40]. Although several factors were associated with seroprevalence in our bivariate analysis, among females in the multivariate model, only age, lifetime number of sex partners, and poverty level remained significant.…”

Section: Weighted Seroprevalence Of Any Human Papillomavirus (Hpv) supporting

confidence: 92%

“…Other studies have described the HPV seroprevalence in the United States, but there has been no population-based study of all 4 HPV vaccine types [13][14][15][16]41]. Clinic-based studies have generally found a higher seropositivity than that revealed by our data.…”

Section: Weighted Seroprevalence Of Any Human Papillomavirus (Hpv) contrasting

confidence: 78%

“…There are some differences in HPV-16 and HPV-11 seroprevalence between our study and NHANES III (1991-1994) [15,16]. A direct-binding virus-like particle IgG enzyme-linked immunosorbent assay was used for the NHANES III analyses, whereas our study used a multiplexed, competitive immunoassay.…”

Section: Weighted Seroprevalence Of Any Human Papillomavirus (Hpv) mentioning

confidence: 89%

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Seroprevalence of Human Papillomavirus Types 6, 11, 16, and 18 in the United States: National Health and Nutrition Examination Survey 2003–2004

et al. 2009

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Section: Weighted Seroprevalence Of Any Human Papillomavirus (Hpv) supporting

confidence: 92%

Section: Weighted Seroprevalence Of Any Human Papillomavirus (Hpv) contrasting

confidence: 78%

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Seroprevalence of Human Papillomavirus Types 6, 11, 16, and 18 in the United States: National Health and Nutrition Examination Survey 2003–2004

et al. 2009

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“…The upward age trends associated with HPV 16 and 18 seroprevalences observed in this study are consistent with those reported in population-based (30), community-based (26, 42), or clinic-based studies (31, 33–35). Only 3 studies have evaluated HPV 6 and/or 11 seroprevalence in men (27, 28, 31) and their findings on age have been mixed. The study of Hariri and colleagues showed a significant, increasing age trend for HPV 11 seroprevalence for males 6- to 49-year-olds, followed by an insignificant decline through age 59 in a population-based study of 3,589 men (28), similar to the age pattern observed for HPV 11 seroprevalence in the current study.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus (HPV) 6, 11, 16, and 18 Seroprevalence Is Associated with Sexual Practice and Age: Results from the Multinational HPV Infection in Men Study (HIM Study)

Viscidi

Lee

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Few human papillomavirus (HPV) serology studies have evaluated type-specific seroprevalence of vaccine HPV types in men. This study investigates seroprevalence of HPV 6, 11, 16, and 18, and associated risk factors in men residing in three countries (United States, Mexico, and Brazil). Methods Data from 1,477 men aged 18 to 70 enrolled in the HPV Infection in Men Study (HIM Study) were analyzed. Serum antibody testing was performed with virus-like particle-based ELISA. Potential risk factors were assessed for individual HPV types by the use of logistic regression. Results Overall, HPV-6, 11, 16, and 18 seroprevalence was 14.8%, 17.3%, 11.2%, and 5.8%, respectively. Thirty-four percent of men were seropositive to one or more HPV types. When examined by sexual practice, 31.2% of men who had sex with women, 65.6% of men who had sex with men (MSM), and 59.4% of men who had sex with both men and women (MSMW) were seropositive to one or more HPV types. Seroprevalence increased with age among young-to-middle-aged men with significant upward age trends observed for HPV 11, 16, and 18. Men with multiple lifetime male anal sex partners were 2 to 4 times more likely to be HPV 6 or 11 seropositive and 3 to 11 times more likely to be HPV 16 or 18 seropositive. Conclusion Our data indicate that exposures to vaccine HPV types were common in men and highly prevalent among MSM and MSMW. Impact Our study provides strong evidence that the practice of same-sex anal intercourse is an independent risk factor for seroprevalence of individual vaccine HPV types. Examination of antibody responses to HPV infections at various anatomic sites in future studies is needed to elaborate on the mechanism.

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“…Most studies of HPV seropositivity in both sexes suggest that seroprevalence is lower among men than women [57] (see also reviews by Dunne et al [21] and Partridge et al [23] ). Possible reasons for this lower seroprevalence in men are speculative, but may include a greater proportion of transient infections or infections with lower viral load in men, or differences in the nature of the anatomic sites infected and immunologic response to infection [21,23] .…”

Section: Hpv Seroprevalencementioning

confidence: 99%

Epidemiology of Mucosal Human Papillomavirus Infection and Associated Diseases

Trottier

Burchell

2009

Public Health Genomics

130

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This article describes the epidemiology of mucosal human papillomavirs (HPV) in adults and children, its mode of transmission and its associated diseases. Over 40 genotypes of HPV infect the epithelial lining of the anogenital tract and other mucosal areas of the body. HPV is the most common sexually transmitted infection globally, with high prevalences found in both females and males. The predominant route of transmission is via sexual contact, although mother-to-child transmission is also possible. HPV infection may exist asymptomatically or may induce the formation of benign or malignant tumours in the genital, oral or conjunctival mucosa. Although most infections clear spontaneously, those that persist result in substantial morbidity and invoke high costs associated with the treatment of clinically relevant lesions. Some 13–18 mucosal HPV types are considered to have high oncogenic potential. HPV is recognized unequivocally as the main causal factor for cervical cancer, and is further responsible for a substantial proportion of many other anogenital neoplasms and head and neck cancers. Infections with HPV types that have low oncogenic risk, such as HPV-6 and 11, are associated with benign lesions of the anogenital areas known as condylomata acuminata (genital warts), oral papillomas, conjunctival papillomas, as well as low-grade squamous intra-epithelial lesions of the cervix. Perinatally acquired HPV can also cause recurrent respiratory papillomatosis in infants and young children. The implementation of HPV vaccination therefore has the potential to prevent a substantial proportion of HPV-related disease in the future.

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Seroepidemiology of Human Papillomavirus Type 11 in the United States: Results From the Third National Health and Nutrition Examination Survey, 1991–1994

Abstract: This study represents the most comprehensive picture of HPV-11 infection in the United States to date, and provides baseline data on the prevalence of HPV-11 before availability of the quadrivalent HPV vaccine.

Cited by 21 publications

References 44 publications

Seroprevalence of Human Papillomavirus Types 6, 11, 16, and 18 in the United States: National Health and Nutrition Examination Survey 2003–2004

Seroprevalence of Human Papillomavirus Types 6, 11, 16, and 18 in the United States: National Health and Nutrition Examination Survey 2003–2004

Human Papillomavirus (HPV) 6, 11, 16, and 18 Seroprevalence Is Associated with Sexual Practice and Age: Results from the Multinational HPV Infection in Men Study (HIM Study)

Epidemiology of Mucosal Human Papillomavirus Infection and Associated Diseases

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