Seroepidemiology of hepatitis B virus infection in Saudi Arabian children: A baseline survey for mass vaccination against hepatitis B

Al-Faleh, Faleh Z.; Ayoola, E. Ayobanji; Arif, Mohammad; Ramia, S.; Al-Rashed, Rashed S.; Al-Jeffry, Mohammed; Al-Mofarreh, Mohammed; Al-Karawi, Mohamed A.; Al-Shabrawy, Mohammed

doi:10.1016/0163-4453(92)93006-c

Cited by 76 publications

(61 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because little is known about the prevalence, distribution and sequences of HBV subgenotypes in Saudi Arabia, particularly Jeddah, no previous data was available (Al-Faleh et al, 1992. In the present study, eight isolates belonging to HBV/D (S18014, S140014, S20014, S140914, S02E12, S2312E, S07E and S10612E) are segregated with subgenotypes D1 reference isolates and inter distance equal 0.006 that was verified this result.…”

Section: Discussionsupporting

confidence: 73%

“…Although, the prevalence of HBV infection is generally high in Asian and African countries (Lee, 1997), little is known about HBV genotypes/sub genotype sequences circulated in Saudi Arabia particularly in Jeddah province (Al-Faleh et al, 1992. In Saudi Arabia, HBV were the most predominant type accounting for 53% of the cases, followed by HCV (30%) and HAV (17%) (Alshabanat et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of Novel D11 Hepatitis B Surface Antigen Subgenotype in Jeddah, Kingdom of Saudi Arabia

Hadad¹,

Alakilli²,

Rabah³

et al. 2015

Biotechnology

View full text Add to dashboard Cite

A B S T R A C T Hepatitis B virus (HBV) infection remains to be a worldwide health problem. In Saudi Arabia, HBV is the most predominant type of hepatitis followed by hepatitis C and hepatitis A while little is known about the molecular epidemiology of the prevalence of HBV genotype/subgenotype particularly in Jeddah. Serum samples were collected from HBV chronic patients and subjected to HBsAg gene amplification. Sequencing and phylogenetic analysis of the entire HBsAg gene sequences revealed that 11 isolates belonged to HBV/D while 4 isolates were associated with HBV/C. Interestingly, HBV/D subgenotypes identified eight HBV/D present isolates belonged to HBV/D1 while three isolates showed a new cluster supporting by a branch with 99% bootstrap value and 4.3-5.8% nucleotide divergence over the entire HBsAg gene from other known subgenotypes D1 to D10, despite they were appearing more related to HBV/D5. The three strains of the new D subgenotype showed unique amino acid sequences consisting of Thr7non, 75Pro in the preS1 gene, 112Ile, 161Gly in the preS2 gene and 196Glu, 197Ala, 238Ser, 259Cys in the S gene. In addition to three amino acid residues in the S gene (373Ile, 374Ala and 381Thr) were specified S118S isolate. Subsequently, it have been verified that HBV/D1 is the most prevalent HBV subgenotype in Jeddah as well as we proposed a novel subgenotype designated HBV/D11. The identification of HBV/D11 novel subgenotypes in the present study suggested that further studies with a large number of subjects in previously examined and unexamined areas may lead to discovering new HBV strain genotypes and/or subgenotypes circulating in Saudi Arabia.

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Identification of Novel D11 Hepatitis B Surface Antigen Subgenotype in Jeddah, Kingdom of Saudi Arabia

Hadad¹,

Alakilli²,

Rabah³

et al. 2015

Biotechnology

View full text Add to dashboard Cite

show abstract

“…The decline in HBVrelated liver disease as an indication for LT is likely related both to the various mass screening programs in the Kingdom, which have enabled the detection of chronically infected HBV patients at various disease stages, and to the introduction of effective antiviral treatment [19][20][21][22][23][24] . Interestingly, similar observations have been noted in various studies from Europe, the United States, Australia, and New Zealand, where massive reductions in HBV-related disease as an indication for LT have been reported [25,26] .…”

Section: Discussionmentioning

confidence: 99%

Liver transplantation for hepatitis B virus: Decreasing indication and changing trends

Al–Hamoudi¹

2015

WJG

View full text Add to dashboard Cite

“…58 Unfortunately, efficacy studies do not take into account the emergence of new HBV mutants which may not be neutralized by vaccine-induced antibodies or detected by ELISA diagnostic kits, which are usually based on the wild type viral antigens. Despite these deficiencies, a sharp drop in HBsAg prevalences among adult blood donors has been observed in recent years.…”

Section: Hepatitis B Vaccination Program In Saudi Arabiamentioning

confidence: 99%

“…55,56 Perinatal and childhood infections caused by horizontal transmission of the virus are a major mode of transmission in this country. 57,58 To interrupt this mode of transmission and to ensure restriction of the reservoir of HBV carriers which serves as a source of future infections, a Royal decree (No 8111 dated 1/6/1408), establishing a committee of specialists, led to an order (No 133140 dated 1/9/1408), making it mandatory for all newborns in Saudi Arabia to. be immunized against hepatitis B virus.…”

Section: Hepatitis B Vaccination Program In Saudi Arabiamentioning

confidence: 99%

Hepatitis B Surface Gene Mutants and their Emerging Role in the Efficacy of HBV Vaccination Programs

Shobokshi

Serebour²,

Skakni³

1999

Ann Saudi Med

View full text Add to dashboard Cite

The advances in molecular biology techniques in the past decade have led to the clarification of hepatitis B viral DNA sequences. However, much remains to be established regarding the emerging hepatitis B mutants. Several putative forms of hepatitis B virus have been isolated, but their epidemiology, natural course of infection and clinical significance remain sketchy. Compounding these problems are factors created by human interventions, such as HBsAg mass immunization, chemotherapy of chronic HBV patients and HBIg prophylaxis of orthotopic liver transplant (OLT) patients, which tend to encourage new mutants to emerge.Despite the availability of HBsAg vaccines and the mass immunization schemes implemented in over 80 countries worldwide, HBV infection continues to be a major public health problem. There are over 350 million chronic carriers worldwide, out of which about 10% die of cirrhosis and hepatocellular carcinoma.

show abstract

Seroepidemiology of hepatitis B virus infection in Saudi Arabian children: A baseline survey for mass vaccination against hepatitis B

Cited by 76 publications

References 13 publications

Identification of Novel D11 Hepatitis B Surface Antigen Subgenotype in Jeddah, Kingdom of Saudi Arabia

Identification of Novel D11 Hepatitis B Surface Antigen Subgenotype in Jeddah, Kingdom of Saudi Arabia

Liver transplantation for hepatitis B virus: Decreasing indication and changing trends

Hepatitis B Surface Gene Mutants and their Emerging Role in the Efficacy of HBV Vaccination Programs

Contact Info

Product

Resources

About