Seroepidemiology of hepatitis B virus infection in 2 million men aged 21–49 years in rural China: a population-based, cross-sectional study

Liu, Jue; Zhang, Shikun; Wang, Qiaomei; Shen, Haiping; Zhang, Man; Zhang, Yiping; Yan, Donghai; Liu, Min

doi:10.1016/s1473-3099(15)00218-2

Cited by 177 publications

(192 citation statements)

References 22 publications

Supporting

Mentioning

177

Contrasting

Order By: Relevance

“…Both univariate and multivariate analysis showed that there was a significant difference between the HBeAg-positive chronic hepatitis B infected patients groups with Knodell HAI ≥ 9 & HAI < 9 and Ishak ≥ 3 & Ishak < 3 by using the GPR index for liver necroinflammatory activity and fibrosis. Our results was also in agreement with a previous report describing the diagnosis of fibrosis and cirrhosis in HBeAg-positive HBV-infected Chinese patients [4]. …”

Section: Discussionsupporting

confidence: 94%

See 1 more Smart Citation

Clinical and histopathological features of chronic hepatitis B virus infected patients with high HBV-DNA viral load and normal alanine aminotransferase level: A multicentre-based study in China

Xing

Zhou

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

BackgroundThe aim of this study is to reveal the clinical and histopathological features of HBsAg-positive and HBeAg-positive chronic hepatitis B infected patients with high level of HBV DNA, from 17 hospitals and medical centres in China, with alanine aminotransferase levels within the lower region of normal range versus those with levels within the upper region of normal range and to investigate the clinical risk factors for the requirement of treatment through the examination of liver biopsy.MethodsLiver biopsy was performed on high level of HBV DNA of 455 patients with HBsAg-positive and HBeAg-positive chronic hepatitis B infection and persistently normal alanine aminotransferase level. Liver necroinflammation and fibrosis were graded per the Knodell histological activity index and Ishak’s fibrosis score, respectively. Univariate analysis of the clinical parameters versus necroinflammation and fibrosis was carried out.ResultsOf the subjects in this multicentre-based study, 5.49% and 10.11% had significant necroinflammation with Knodell histological activity index ≥ 9 and hepatic fibrosis stages with Ishak scores ≥ 3, respectively. The subjects were stratified into three age groups (30–39, 40–49 and ≥ 50 years), and our data clearly suggested that age, particularly in the age group over 50, was an independent predictor of liver necroinflammation and fibrosis. Lower HBV-DNA viral levels were found in patients with Knodell histological activity index ≥ 9 or advanced fibrosis (Ishak scores ≥ 3).ConclusionOur results showed that histological changes in liver tissues were observed in a significant proportion of patients with persistently normal alanine aminotransferase level. According to the data evaluation results, liver biopsy is advisable for HBeAg-positive chronic hepatitis B infected patients aged older than 40 and high HBV-DNA viral load in China.

show abstract

Section: Discussionsupporting

confidence: 94%

“…In China, the prevalence of hepatitis B surface antigen (HBsAg) is high and affects 8.5–10.5% of the adult population [4]. The management of HBV in China is a complex issue, with various intermingled clinical, economic, social and cultural aspects.…”

Section: Introductionmentioning

confidence: 99%

Clinical and histopathological features of chronic hepatitis B virus infected patients with high HBV-DNA viral load and normal alanine aminotransferase level: A multicentre-based study in China

Xing

Zhou

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…China has the largest rural population and labour resources in the world, 15 and rural population flow is the main component of China's overall population flow and has an important impact on the spatial pattern of the population in terms of regional economic and social development. 16 A hepatitis B prevalence of 3.7% (642) in a large sample was previously reported, 17 while another study 18 reported a 6% (124 274) HBsAg positive rate among males in rural areas. The rural economy lags behind the urban economy in China, along with health and education resources.…”

Section: Introductionmentioning

confidence: 77%

Prevalence and influencing factors of hepatitis B among a rural residential population in Zhejiang Province, China: a cross-sectional study

et al. 2017

View full text Add to dashboard Cite

ObjectivesTo reveal the prevalence and associated influencing factors of hepatitis B among a rural residential population in Zhejiang, China, in order to help develop specific control strategies.MethodsWe conducted a cross-sectional study among a rural residential population in Zhejiang, China. Stratified multistage cluster sampling was utilised in five districts; a structured questionnaire was used to collect the information such as age, gender, education, occupation, living status, and other health related information of the participants by trained local staff; and the hepatitis B virus (HBV) infection status of the participants was determined by the chemiluminescence immunoassay test. Univariate and multivariate analyses were applied to evaluate the influencing factors of HBV infection. The odds ratio of each related factor was assessed with or without adjustment separately.ResultsThe mean age of the 16 601 participants (7881 males and 8720 females) who completed the survey was 40.28±19.47 years. The positive rate of hepatitis B surface antigen (HBsAg) was 4.04% (95% CI 3.74% to 4.35%), and 3.85% when standardised by age and gender. Univariate analysis showed that age, educational level, occupation, living status, history of hepatitis B examinations, history of blood transfusion, vaccination, family history, coastal living, and district were the potential influencing factors. Multivariate logistic regression indicated that occupation, living status, history of hepatitis B examinations, vaccination and district were the influencing factors. Undertaking a service-based tertiary industry job (ORa 1.19, 95% CI 0.94 to 1.51) and non-single living (ORa 2.84, 95% CI 2.17 to 3.70) might be risk factors, while vaccination (ORa 0.43, 95% CI 0.34 to 0.53) and history of hepatitis B examinations (ORa 0.71, 95% CI 0.48 to 1.03) were potential protective factors.ConclusionsThe prevalence of hepatitis B is at an intermediate epidemic level in a rural residential population in Zhejiang, China. Raising vaccination coverage, especially in adults, is a suitable strategy for the prevention and control of hepatitis B.

show abstract

“…In developing countries, horizontal and vertical transmissions, in developed countries, parenteral drug use, sexual transmission, hemodialysis and surgical interventions are responsible for HBV transmission (12,13). HBV prevalence in Europe and USA was reported to be about 0.1-0.5%, and in Far East, China and tropical countries the HBV prevalence increases to 5-20% (14,15,16). As HBV prevalence shows differences in different geographic areas and countries, it can also be reported different in various areas inside a country.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of Hepatitis B Virus Infection in İstanbul: A 20-year Survey

Furuncuoglu¹,

Saglam²,

Bolukbas³

et al. 2016

vhd

View full text Add to dashboard Cite

ÖZObjective: Turkey is an intermediate endemic country for hepatitis B virus (HBV) infection, with the prevalence rates showing regional differences. The aim of this study was to determine the recent prevalence of HBV infection among adults in İstanbul and to evaluate the impact of national vaccination program that started in 1998. Materials and Methods: Data of three healthcare centers from 3 different districts in İstanbul between 1995 and 2015 were obtained. HBV status of the participants was evaluated according to their hepatitis B surface antigen (HBsAg) and anti-HBs results. The change in HBV prevalence was evaluated by dividing the time included in the study into three periods: 1995-2002, 2003-2009 and 2010-2015. Statistical comparison between groups studied in each period was performed. To evaluate the impact of vaccination, the patients of 15-17 years of age were compared with the rest of the last study group. Results: Totally, 26001 adult patients were included in the study.HBsAg and anti-HBs tested positive in 4.24% and 16.81% of patients, respectively. When the 20 years included in the study were divided into three periods and each studied separately, the positive results for HBsAg decreased from 5.34% to 4.8% and 3.08%, and positive anti-HBs results increased from 14.24% to 15.45% and 19.57%, the difference between the groups being statistically significant (p<0.001). In vaccinated group (n=287), no one tested positive for HBsAg and 30.3% of patients tested positive for antiHBs, being statistically different from the rest of the group (p<0.001). Conclusion:Despite the positive effects of vaccination, chronic HB remains a serious health problem.

show abstract

Seroepidemiology of hepatitis B virus infection in 2 million men aged 21–49 years in rural China: a population-based, cross-sectional study

Cited by 177 publications

References 22 publications

Clinical and histopathological features of chronic hepatitis B virus infected patients with high HBV-DNA viral load and normal alanine aminotransferase level: A multicentre-based study in China

Clinical and histopathological features of chronic hepatitis B virus infected patients with high HBV-DNA viral load and normal alanine aminotransferase level: A multicentre-based study in China

Prevalence and influencing factors of hepatitis B among a rural residential population in Zhejiang Province, China: a cross-sectional study

Seroepidemiology of Hepatitis B Virus Infection in İstanbul: A 20-year Survey

Contact Info

Product

Resources

About