Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico

Alvarado‐Esquivel, Cosme; Hernández‐Tinoco, Jesús; Sánchez‐Anguiano, Luis Francisco; Ramos-Nevárez, Agar; Cerrillo-Soto, Sandra Margarita; Estrada-Martínez, Sergio; Martinez-Ramirez, Lucio; Pérez-Álamos, Alma Rosa; Guido-Arreola, Carlos Alberto

doi:10.1186/1471-2334-14-484

Cited by 17 publications

(21 citation statements)

References 22 publications

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“…Our CMV result (73.6%) was similar to that obtained in western Sudan Hamdan et al [18]. Who reported that 72.2% of pregnant women were anti-CMV-IgG antibodies reactive, but higher than result obtained in Mexico, (65.6%) by Alvarado-Esquivel C et al [19] and less than those obtained in Nigeria (91.1%) by Hamid et al [20], in Palestine (96.6%) by Tahani et al [21] and in China (98.7%) by Lingqing et al [22]. These differences might be attributed to endemic variations of these countries with CMV infections and different health policies enrolled in these countries.…”

Section: Discussionsupporting

confidence: 88%

Sero-Detection of Cytomegalovirus and Rubella Virus IgG Antibodies among Sudanese Pregnant Women in Khartoum State-Sudan

jalel¹,

Saleh²,

Ibrahim³

et al. 2017

JHVRV

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Background: Cytomegalovirus and Rubella virus are the most common causes of congenital infections, which increase morbidity and mortality at birth and one of the common causes of abortion in developing countries.Methodology: plasma samples obtained from 87 pregnant women's, the samples were obtained from Omdurman Friendship Hospital 53(61%), AL-Saudi Specialized Hospital 21(25%) and Ultra lab Diagnostic Centre 13(14%). all samples were examined for presence of CMV and Rubella virus IgG antibodies by using an ELISA test. Results:The result showed that out of 87 blood samples investigated, 64(73.6%) were positive for CMV, while the result 23(26.4%) were negative and 85(97.7%) were positive for rubella, while the result 2(2.3%) were negative, where was 62(71.2%) samples had both CMV and Rubella virus IgG antibodies, 25(28.8%) had either CMV or Rubella virus IgG antibodies and there was no sample negative for both CMV and Rubella virus IgG antibodies.Conclusion: the present study observed the high prevalence rate of CMV and rubella virus IgG antibodies among pregnant women in Khartoum State. The level of infections is higher in pregnant women without history of miscarriage than those aborted women.

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Section: Discussionsupporting

confidence: 88%

Sero-Detection of Cytomegalovirus and Rubella Virus IgG Antibodies among Sudanese Pregnant Women in Khartoum State-Sudan

jalel¹,

Saleh²,

Ibrahim³

et al. 2017

JHVRV

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“…We performed the statistical analysis with the aid of the software Epi Info version 7, and SPSS 15.0 (SPSS Inc., Chicago, Illinois). For calculation of the sample size, we used a 95% confidence level, a power of 80%, a 1:1 proportion of cases and controls, a reference seroprevalence of 65.6% [ 27 ] as the expected frequency of exposure in controls, and an odds ratio of 2.3. The result of the sample size calculation was 134 cases and 134 controls.…”

Section: Methodsmentioning

confidence: 99%

Lack of association between cytomegalovirus infection and hypertensive disorders in pregnancy: a case-control study in Durango, Mexico

Alvarado‐Esquivel

Sandoval-Carrillo²,

Vazquez-Alaniz

et al. 2017

EuJMI

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It is not clear whether infection with cytomegalovirus (CMV) is associated with hypertensive disorders in pregnant women. Through a case-control study design, 146 women suffering from hypertensive disorders in pregnancy (cases) and 146 age-matched normotensive pregnant women (controls) were examined for the presence of anti-CMV IgG and IgM antibodies with enzyme-linked immunoassays. IgM seropositive samples were further assayed by enzyme-linked fluorescent assay (ELFA).Anti-CMV IgG antibodies were found in 138 (94.5%) controls and in 136 (93.2%) cases (odds ratio [OR] = 0.78; 95% confidence interval [CI]: 0.30–2.05; P = 0.62). High (>18 IU/ml) levels of anti-CMV IgG antibodies were found in 37.7% of the 138 seropositive controls and in 34.6% of the 136 seropositive cases (OR = 0.87; 95% CI: 0.53–1.43; P = 0.59). Anti-CMV IgM antibodies were found in 1 (0.7%) of the controls but in none of the cases using ELFA (P = 1.0). Seropositivity to CMV was not associated with a previous preeclampsia and was similar among cases regardless their mean systolic and diastolic blood pressures, and mean arterial blood pressure.No serological evidence of an association between CMV infection and hypertensive disorders of pregnancy was found. Further research to elucidate the role of CMV in hypertensive disorders in pregnancy should be conducted.

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“…We performed a cross-sectional study using stored serum samples from a previous survey of cytomegalovirus infection in pregnant women in Durango City, Mexico [ 15 ]. Samples were originally obtained to determine the seroprevalence of anti-cytomegalovirus antibodies in pregnant women attending a public primary health care center (Clinic of Family Medicine, Institute of Security and Social Services of State Workers) in Durango City, Mexico.…”

Section: Methodsmentioning

confidence: 99%

Rubella Immune Status in Pregnant Women in a Northern Mexican City

et al. 2016

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BackgroundThe seroepidemiology of rubella virus infection in pregnant women in northern Mexico is largely unknown. We sought to determine the seroprevalence of rubella virus infection in pregnant women in the northern Mexican city of Durango, Mexico. Seroprevalence association with the socio-demographic, clinical and behavioral characteristics of the pregnant women was also investigated.MethodsThrough a cross-sectional study, we determined the seroprevalence of IgG and IgM anti-rubella virus in 279 pregnant women (mean age 29.17 ± 5.96 years; range 15 - 43 years) attending in a clinic of family medicine using enzyme-linked fluorescent assays. A questionnaire was used to obtain the socio-demographic, clinical and behavioral characteristics of the pregnant women. The association of rubella seropositivity and characteristics of the women was assessed by bivariate and multivariate analyses.ResultsAnti-rubella IgG antibodies (≥ 15 IU/mL) were found in 271 (97.1%) of the 279 pregnant women examined. None of the 279 pregnant women were positive for anti-rubella IgM antibodies. Multivariate analysis of socio-demographic, clinical and behavioral variables showed that seroreactivity to rubella virus was positively associated with national trips (OR = 7.39; 95% CI: 1.41 - 38.78; P = 0.01), and negatively associated with age (OR = 0.26; 95% CI: 0.06 - 0.99; P = 0.04).ConclusionsRate of rubella immunity in pregnant women in the northern Mexican city of Durango is high. However, nearly 3% of pregnant women are susceptible to rubella in our setting. Risk factors associated with rubella seropositivity found in this study may be useful for optimal design of preventive measures against rubella and its sequelae.

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Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico

Cited by 17 publications

References 22 publications

Sero-Detection of Cytomegalovirus and Rubella Virus IgG Antibodies among Sudanese Pregnant Women in Khartoum State-Sudan

Sero-Detection of Cytomegalovirus and Rubella Virus IgG Antibodies among Sudanese Pregnant Women in Khartoum State-Sudan

Lack of association between cytomegalovirus infection and hypertensive disorders in pregnancy: a case-control study in Durango, Mexico

Rubella Immune Status in Pregnant Women in a Northern Mexican City

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