Seroepidemiological Survey of Wild Rats for Seoul Virus in Indonesia

Ibrahim, Ima-Nurisa; Sudomo, M.; Morita, Çhiharu; Uemura, Sachiko; Muramatsu, Yasukazu; Ueno, Hiroshi; Kitamura, Takashi

doi:10.7883/yoken1952.49.69

Cited by 18 publications

(20 citation statements)

References 4 publications

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“…This study supports previous findings that many SE Asian rodent species can be infected with hantaviruses (Ibrahim et al 1996;Nitatpattana et al 2000Nitatpattana et al , 2002, with nine species found seropositive. The antibodies detected in some of the rodent species here may represent spillover infections of known hantavirus species into non-reservoir host species, or may reflect exposure to a yet unidentified hantavirus species or lineage (as suggested by the molecular evidence for Seoul-like viruses in at least two Rattus species (Wang et al 2000).…”

Section: Discussionsupporting

confidence: 92%

“…The overall prevalence of antibodies detected at our sites is comparable to findings from previous studies in Thailand with values of between 1.1 and 4.0% (Nitatpattana et al 2002;Kantakamalakul et al 2003;Pattamadilok et al 2006). The prevalences found for the different rodent species were also similar to previous findings in the region (Ibrahim et al 1996;Nitatpattana et al 2000;Reynes et al 2003). A seroprevalence of 8.2% was detected in rodents trapped in and around Phnom Penh in Cambodia in 1998 (Reynes et al 2003).…”

Section: Discussionsupporting

confidence: 89%

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Rodent-Borne Hantaviruses in Cambodia, Lao PDR, and Thailand

et al. 2011

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In order to evaluate the circulation of hantaviruses present in southeast Asia, a large scale survey of small mammal species was carried out at seven main sites in the region (Cambodia, Lao People's Democratic Republic, and Thailand). Small scale opportunistic trapping was also performed at an eighth site (Cambodia). Using a standard IFA test, IgG antibodies reacting to Hantaan virus antigens were detected at six sites. Antibody prevalence at each site varied from 0 to 5.6% with antibodies detected in several rodent species (Bandicota indica, B. savilei, Maxomys surifer, Mus caroli, M. cookii, Rattus exulans, R. nitidius, R. norvegicus, and R. tanezumi). When site seroprevalence was compared with site species richness, seropositive animals were found more frequently at sites with lower species richness. In order to confirm which hantavirus species were present, a subset of samples was also subjected to RT-PCR. Hantaviral RNA was detected at a single site from each country. Sequencing confirmed the presence of two hantavirus species, Thailand and Seoul viruses, including one sample (from Lao PDR) representing a highly divergent strain of Seoul virus. This is the first molecular evidence of hantavirus in Lao PDR and the first reported L segment sequence data for Thailand virus.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Rodent-Borne Hantaviruses in Cambodia, Lao PDR, and Thailand

et al. 2011

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“…Epizootiology studies have reported the presence of rats in Vietnam and Singapore with antibodies against SEOV (Truong et al, 2009;Johansson et al, 2010). SEOV has also been detected in rodents from Indonesia (Ibrahim et al, 1996). In the Mekong Delta of Vietnam, rodents can be infected with DOBV and SEOV with a positive rate of 6.9% (Van Cuong et al, 2015).…”

Section: Pathogenic Hantaviruses and Their Reservoirsmentioning

confidence: 99%

Hantavirus infection: a global zoonotic challenge

et al. 2017

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Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however, hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide.

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“…There have been a few reports on hantavirus infection in humans and animals in Indonesia. Seoul virus (SEOV) in Rattus norvegicus in Jakarta was demonstrated serologically [8] and genetically [17]. Thottapalayam virus (TPMV) in shrews (Suncus murinus) in Thousand Islands regency was shown by serological examination [13].…”

mentioning

confidence: 99%

Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia

Ibrahim

Shimizu

Yoshimatsu

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne zoonotic disease caused by hantavirus infection. Many HFRS cases have been reported in East Asia and North Europe, while the situation in Southeast Asia remains unclear. In this study, the prevalence of hantavirus infection in rodents and humans in Thousand Islands regency, which is close to the port of Jakarta, one of the largest historic ports in Indonesia, was investigated. A total of 170 rodents were captured in 2005, and 27 (15.9%) of the rodents were antibody-positive against Hantaan virus antigen in an immunofluorescence assay (IFA) and Western blotting. Despite the high prevalence in rodents, human sera collected from 31 patients with fever of unknown origin and 20 healthy volunteers in the islands in 2009 did not show positive reaction to the antigen in IFA. To identify the virus in rodents genetically, a total of 59 rodents were captured in 2009. Sera from the rodents were screened for antibody by ELISA, and lung tissues were subjected to RT-PCR. 20 (33.9%) of the 59 rodents were antibody-positive, and 3 of those 20 rodents were positive for S and M genome segments of hantaviruses. Genetic analysis showed that the viruses belonged to Seoul virus and formed a cluster with those in Vietnam and Singapore. These results suggest that a unique group of Seoul viruses has spread widely in Southeast Asia.

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Seroepidemiological Survey of Wild Rats for Seoul Virus in Indonesia

Cited by 18 publications

References 4 publications

Rodent-Borne Hantaviruses in Cambodia, Lao PDR, and Thailand

Rodent-Borne Hantaviruses in Cambodia, Lao PDR, and Thailand

Hantavirus infection: a global zoonotic challenge

Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia

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