Seroepidemiological survey of the prevalence of Helicobacter pylori infection in Sabah, Malaysia

Mori, Daisuke; John, Jecelyn Leaslie; Sabri, Shahnaz Irwani Binti; Shaharom, Saliz Mazrina Binti; Iha, Hidekatsu; Yamaoka, Yoshio; Matsumoto, Takashi; Ahmed, Kamruddin

doi:10.1016/j.ijregi.2021.12.012

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…Another noteworthy genus is Helicobacter, which is one of the predominant bacteria observed in rodents from Lambir Hills National Park and Sungai Sibau Kapit. While certain members within this genus, like Helicobacter pylori, were detected and have a notable history of infection in Malaysia [42], the seroprevalence of H. pylori has been globally declining, a trend that is also evident in Borneo [43]. However, the most abundant Helicobacter species in all rodent individuals was found to be Helicobacter apodemus.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of pathogenic bacteria in wild rodents near natural water bodies from Sarawak, Borneo

Azmi,

William-Dee,

Morni

et al. 2023

Preprint

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The gut microbiota of wild rodents is characterised by high bacterial diversity that could be influenced by the surrounding environment. However, specific environmental features that directly influence the gut bacterial diversity of rodents remain relatively unknown. Natural water bodies could play a role in shaping the gut microbiota as rodents could act as a reservoir for the bacterial community that is present in water surfaces. Characterising the gut microbiome of wild rodents is essential as the transmission of pathogenic bacteria to human settlements could occur due to the synanthropic nature of the rodents. Rodent trappings and water quality assessments of nearby natural bodies were carried out in forested areas adjacent to human settlements across Sarawak, Borneo. Nanopore sequencing was performed on the extracted DNA from the collected faecal samples (n=16). 51 pathogenic bacterial genera, representing approximately 11% of the overall bacterial abundance, were detected from sequencing 16 rodent individuals from five distinct species. These bacteria could cause zoonotic diseases and includes the genera Clostridium, Klebsiella, and Helicobacter. Some bacterial species were also found to be commonly shared between study sites (e.g. Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus). Correlation analysis revealed that only one genus (Enterococcus) had significant correlation with water quality (BOD). This study highlights the potential public health risks that could be caused by the transmission of pathogenic bacteria to nearby human settlements by rodents as the host.

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Section: Discussionmentioning

confidence: 99%

Prevalence of pathogenic bacteria in wild rodents near natural water bodies from Sarawak, Borneo

Azmi,

William-Dee,

Morni

et al. 2023

Preprint

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Evaluation of IL-17F A7488G polymorphism in Helicobacter pylori-infected patients: a case–control study

Hormati

Roknabadi

Aghaali

et al. 2023

Annals of Medicine &Amp; Surgery

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Objective: Interleukin 17 (IL-17) plays an important role in the inflammation of the gastric mucosa and, in severe cases, the development of gastric cancer. Thus, the authors aimed to evaluate the IL-17F A7488G polymorphism in Helicobacter pylori (H. pylori) patients. Patients and methods: A total of 86 adults (in two H. pylori-positive and H. pylori-negative groups) were included in the study. To identify the infection, rapid urease test and polymerase chain reaction (PCR) were performed. The cagA gene was also evaluated as a bacterial virulence factor. PCR–restriction fragment length polymorphism was used to investigate the IL-17F A7488G polymorphism in gastric biopsies using the NlaIII enzyme. Results: 96.5% of patients in both groups did not show any mutation and had AA genotype, and only three patients infected with cagA-carrying H. pylori strains had polymorphism in the IL-17F A7488G gene, which included AG (one case) and GG (two cases) patterns. No significant relationship was found between these polymorphisms in the two groups of H. pylori-positive and H. pylori-negative patients, while, interestingly, a significant difference was observed between the polymorphisms and the presence of the cagA gene. Conclusion: This report is one of the first to demonstrate the association of IL-17F A7488G polymorphism with H. pylori infection and the presence of the cagA gene. Although no significant association between IL-17F polymorphism and H. pylori infection was found in the population of this study, the patients with mutated genotypes were positive for the cagA gene, which was statistically significant. Therefore, the possibility of the role of pathogenic strains in causing mutations in cytokine genes is more conceivable.

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Seroepidemiological survey of the prevalence of Helicobacter pylori infection in Sabah, Malaysia

Cited by 2 publications

References 36 publications

Prevalence of pathogenic bacteria in wild rodents near natural water bodies from Sarawak, Borneo

Prevalence of pathogenic bacteria in wild rodents near natural water bodies from Sarawak, Borneo

Evaluation of IL-17F A7488G polymorphism in Helicobacter pylori-infected patients: a case–control study

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