Seroepidemiological study of toxoplasmosis in women referred to a pre-marriage counseling center in Alborz Province, Iran

Shahighi, Melica; Heidari, Aliehsan; Keshavarz, Hossein; Bairami, Amir; Shojaee, Saeedeh; Sezavar, Monireh; Salimi, Mehri; Teimouri, Aref

doi:10.1186/s13104-021-05581-0

Cited by 6 publications

(4 citation statements)

References 32 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, we reported a signi cantly lower toxoplasma seroprevalence rate of 12.5% among pregnant women in Kuwait compared to 53.1% reported more than a decade ago [16,22]. Similar decreasing trends were also reported among pregnant women in Saudi Arabia (from 38.8% in 2014 to 21.2% in 2021) and Iran (from 39.2% to 20.1% in 2021) (Table 2) [27,32,40,42].…”

Section: Discussionsupporting

confidence: 60%

Knowledge, Attitude And Preventive Behavior Towards Toxoplasmosis Among Kuwaiti Women With/Without Pregnancy Experience: A Cross Sectional Study

Iqbal¹,

Khadadah²,

Mohammed³

2021

Preprint

View full text Add to dashboard Cite

Background: Toxoplasmosis is caused by an obligate intracellular opportunistic protozoan parasite, Toxoplasma gondii, with a worldwide distribution. T. gondii infection among pregnant women during the first trimester may transmit infection to the fetus with serious congenital consequences. No data is available on knowledge, attitude and preventive behavior towards toxoplasmosis among pregnant women in Kuwait. This cross-sectional study evaluated knowledge, attitude, and preventive behavior towards toxoplasmosis among women in Kuwait, and reviewed the situation in the Middle east.Methods: Data related to socioeconomic status, knowledge and attitude towards toxoplasmosis were collected from 326 adult female school/university students, and 86 pregnant women through a self-administered online questionnaire during 2019-2021. Participants were divided into two main groups: women with pregnancy experience (PEG) and never-pregnant group (NPG).Results: PEG (n=212) included 114 currently pregnant and 98 women with history of an earlier pregnancy. NPG included 200 subjects. All participants belonged to a medium-to-high social status and minimum high school education. Nearly 50% of PEG women had inadequate knowledge towards toxoplasma infection, and only 33 (15.6%) knew its mode of transmission compared to 35 (17.5%) in the NPG (P=0.597). A significantly higher number of women in PEG (97 of 212, 45.8%) knew it can be prevented compared to 66 of 200 (33%) in NPG (P= 0.008). Only 35 (16.5%) of PEG women knew about screening tests for toxoplasma infection, and their main source of information on toxoplasmosis was healthcare professionals and family/friends compared with NPG women who got information through newspapers/books. PEG Women exhibited enhanced preventive behavior towards toxoplasmosis. Nearly 50% of all PEG participants lacked basic knowledge towards toxoplasmosis but >90% of them avoided most high-risk activities during their pregnancy. In addition, this is the first study in the Middle east conducted through an online survey to collect relevant information related to toxoplasmosis from pregnant women. Conclusions: This study highlights inadequate knowledge and preventive behavior towards toxoplasmosis among Kuwaiti women. Thus, health education on toxoplasmosis should be offered to all adult/pregnant women to reduce congenital toxoplasmosis.

show abstract

Section: Discussionsupporting

confidence: 60%

Knowledge, Attitude And Preventive Behavior Towards Toxoplasmosis Among Kuwaiti Women With/Without Pregnancy Experience: A Cross Sectional Study

Iqbal¹,

Khadadah²,

Mohammed³

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Toxoplasma gondii , a member of Apicomplexa , is an intracellular parasitic protozoan that infects approximately one in three people worldwide, causing a devastating disease called toxoplasmosis that threatens not only human beings but also bird and animal populations [ 1 , 2 , 3 ]. The feline is the only known definitive host of T. gondii [ 4 ]. The infection is transmitted to warm-blooded vertebrates through food or water contaminated with feline feces or undercooked meat containing tissue cysts [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Ameliorate Murine Chronic Toxoplasmosis

Sarhan,

Felemban,

Alelwani

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Toxoplasma gondii causes a global parasitic disease. Therapeutic options for eradicating toxoplasmosis are limited. In this study, ZnO and Mg-doped ZnO NPs were prepared, and their structural and morphological chrematistics were investigated. The XRD pattern revealed that Mg-doped ZnO NPs have weak crystallinity and a small crystallite size. FTIR and XPS analyses confirmed the integration of Mg ions into the ZnO framework, producing the high-purity Mg-doped ZnO nanocomposite. TEM micrographs determined the particle size of un-doped ZnO in the range of 29 nm, reduced to 23 nm with Mg2+ replacements. ZnO and Mg-doped ZnO NPs significantly decreased the number of brain cysts (p < 0.05) by 29.30% and 35.08%, respectively, compared to the infected untreated group. The administration of ZnO and Mg-doped ZnO NPs revealed a marked histopathological improvement in the brain, liver, and spleen. Furthermore, ZnO and Mg-doped ZnO NPs reduced P53 expression in the cerebral tissue while inducing CD31 expression, which indicated a protective effect against the infection-induced apoptosis and the restoration of balance between free radicals and antioxidant defense activity. In conclusion, the study proved these nanoparticles have antiparasitic, antiapoptotic, and angiogenetic effects. Being nontoxic compounds, these nanoparticles could be promising adjuvants in treating chronic toxoplasmosis.

show abstract

“…However, a wide variety of intermediary hosts, including humans, are capable of asexual reproduction. ( 3) The initial infection caused by T. gondii typically leads to moderate symptoms resembling those of influenza in persons with normal immunity. However, those with impaired immune systems, such as those with AIDS, organ transplants, or cancer, are at risk of experiencing serious consequences due to the reactivation of tissue cysts, which can be fatal.…”

Section: Introductionmentioning

confidence: 99%

Current Trend of Toxoplasmosis in Cancer Patients, Sohag University Hospitals, Sohag, Egypt

Fadel,

EL hady,

Ahmed

et al. 2024

Sohag Medical Journal

View full text Add to dashboard Cite

Background and Aim:Human toxoplasmosis is caused by the ubiquitous intracellular apicomplexan pathogen, Toxoplasma gondii (T. gondii). It has been acclaimed as the most successful parasite ever, infecting up to one-third of the global population. The objective of this study was to evaluate the seroprevalence of T. gondii in individuals with different types of malignancies in comparison to a control group of healthy individuals. Patients and Methods: A case-control study was conducted from March 2022 to June 2023. Sera of 50 patients with different cancer types and 50 healthy individuals were analyzed for Toxoplasma gondii IgG and IgM using indirect ELISA. Results: A total of 100 individuals were evaluated, and it was found that 67 of them (67%) tested positive for Toxoplasma IgG antibodies. Seroprevalence was significantly higher (p=0.016) in cancer patients (64%) than in controls. Moreover, 15% were positive for Toxoplasma IgM. Notably, the prevalence was found to be greater among cancer patients compared to the control group, with (18% vs 12%), respectively. Patients with hematological malignancies exhibited a slightly greater rate of IgG seropositivity compared to those with solid organ tumors (85% and 77% respectively). A similar trend of Toxoplasma IgM, with a prevalence of 25% in hematological malignancies and 9.1% in solid organ tumors. Conclusion: T. gondii infection was shown to be substantially more common in cancer patients. Seropositive patients are at a high risk for reactivation, whereas seronegative patients are at risk for infection. Our research shows that toxoplasmosis screening must be promoted in these settings.

show abstract

Seroepidemiological study of toxoplasmosis in women referred to a pre-marriage counseling center in Alborz Province, Iran

Cited by 6 publications

References 32 publications

Knowledge, Attitude And Preventive Behavior Towards Toxoplasmosis Among Kuwaiti Women With/Without Pregnancy Experience: A Cross Sectional Study

Knowledge, Attitude And Preventive Behavior Towards Toxoplasmosis Among Kuwaiti Women With/Without Pregnancy Experience: A Cross Sectional Study

Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Ameliorate Murine Chronic Toxoplasmosis

Current Trend of Toxoplasmosis in Cancer Patients, Sohag University Hospitals, Sohag, Egypt

Contact Info

Product

Resources

About