Seroepidemiological study of severe fever with thrombocytopenia syndrome in animals and humans in Okinawa, Japan

Kuba, Yumani; Kyan, Hisako; Azama, Yasuhito; Fukuchi, Yoshimune; Park, Eun-Sil; Kakita, Tetsuya; Oyama, Minori; Maeshiro, Noriyuki; Miyahira, Masato; Nidaira, Minoru; Maeda, Ken; Morikawa, Shigeru; Taniguchi, Kiyosu

doi:10.1016/j.ttbdis.2021.101821

Cited by 7 publications

(7 citation statements)

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“…To the best of our knowledge, this is the first study to report the presence of SFTSV RNA in H. hystricis larvae collected from a wild mongoose. Although the prevalence of SFTSV in ticks and mongooses is low, these results, combined with the results of a previous seroprevalence survey that found anti-SFTSV antibodies in wild mongooses (6), suggest that H. hystricis and wild mongooses are involved in the maintenance of SFTSV in nature on the main island of Okinawa. Continuous surveillance of SFTSV in ticks and animals in Okinawa is needed to prevent future SFTSV infections.…”

Section: Short Communicationmentioning

confidence: 48%

“…This indicates that H. hystricis is also a potential vector for SFTSV and may cause sporadic transmission to humans (13). Although the prevalence of SFTSV in ticks from wild mongooses was low, the presence of anti-SFTSV antibodies in wild mongooses in a previous study (6) and the presence of SFTSV RNA in H. hystricis larvae-infested wild mongoose in this study suggests that H. hystricis and wild mongooses are involved in the maintenance of SFTSV in nature on the main island of Okinawa. However, the sample size in the present study was small with low number of sampling sites, and hence, it was not possible to fully understand the circulation of SFTSV in ticks in Okinawa, for which continuous monitoring of SFTSV in ticks of this region is necessary.…”

Section: Short Communicationmentioning

confidence: 88%

“…The patient was a 67-year-old man who lived in the central area of the main island of Okinawa and had no domestic and/or foreign travel history during the incubation period. Although a seroprevalence survey indicated a low frequency of SFTSV exposure among Okinawa residents, the results suggested that outdoor activity was associated with an increased risk of tick bites in Okinawa (6). Therefore, there are concerns regarding the risk of SFTSV infection transmitted via tick bites.…”

mentioning

confidence: 95%

“…Therefore, there are concerns regarding the risk of SFTSV infection transmitted via tick bites. A previous seroepidemiological study showed the presence of anti-SFTSV antibodies in wild mongooses (Herpestes auropunctatus) (6). However, the relationship between wild mongooses and ticks regarding SFTSV circulation remains unknown.…”

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confidence: 98%

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Severe Fever with Thrombocytopenia Syndrome Virus RNA in Ticks from Wild Mongooses in Okinawa Prefecture, Japan

et al. 2022

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic tickborne disease caused by SFTS virus (SFTSV). SFTSV has a wide spectrum of animal hosts and is considered to circulate in an enzootic tick-vertebrate-tick cycle. A previous seroepidemiological study showed the presence of anti-SFTSV antibodies in wild mongooses (Herpestes auropunctatus) and indicated that outdoor activity was associated with an increased risk of tick bites among Okinawa residents. However, the association of SFTSV with wild mongooses and ticks remains unclear.To understand the association between ticks and mongooses with respect to the SFTSV enzootic cycle, we investigated the presence of SFTSV RNA in ticks collected from wild mongooses on the Okinawa Island. A total of 638 ticks belonging to 2 genera and 3 species (Haemaphysalis hystricis, Haemaphysalis formosensis, and Ixodes granulatus) were collected from 22 wild mongooses from 2016 to 2021. SFTSV RNA was detected in two pools of H. hystricis larvae collected from a wild mongoose in the central area of the main island of Okinawa in 2017. Although the prevalence of SFTSV in ticks from wild mongooses is low, endemic circulation of the virus in Okinawa should be carefully monitored to prevent future infections.

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Section: Short Communicationmentioning

confidence: 48%

Section: Short Communicationmentioning

confidence: 88%

mentioning

confidence: 95%

mentioning

confidence: 98%

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Severe Fever with Thrombocytopenia Syndrome Virus RNA in Ticks from Wild Mongooses in Okinawa Prefecture, Japan

et al. 2022

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“…Besides, many other species of small wild animals infected with SFTSV may serve as the natural amplifying hosts. In Table 3 , the SFTSV antibodies or RNA have been detected in more than 16 kinds of wild animals, namely, rodents, Asian house shrews, hedgehogs, water deer, wild deer, wild boars, Siberian roe deer, gorals, raccoon dogs, carrion crow, yellow weasels, hares, rock pigeons, pheasants, turtledoves, and mongooses [ 4 , 23 , 35 , 36 , 38 , 40 , 52 – 55 ]. The highest SFTSV antibody positive rate was seen in yellow weasels (91.11%) detected in China [ 36 ].…”

Section: Main Textmentioning

confidence: 99%

Vectors, Hosts, and the Possible Risk Factors Associated with Severe Fever with Thrombocytopenia Syndrome

Wang

Liu

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Severe fever with thrombocytopenia syndrome (SFTS) is a disease caused by infection with the SFTS virus (SFTSV). SFTS has become a crucial public health concern because of the heavy burden, lack of vaccines, effective therapies, and high-fatality rate. Evidence suggests that SFTSV circulates between ticks and animals in nature and is transmitted to humans by tick bites. In particular, ticks have been implicated as vectors of SFTSV, where domestic or wild animals may play as the amplifying hosts. Many studies have identified antigens and antibodies against SFTSV in various animals such as sheep, goats, cattle, and rodents. Besides, person-to-person transmission through contact with blood or mucous of an infected person has also been reported. In this study, we reviewed the literature and summarized the vectors and hosts associated with SFTS and the possible risk factors.

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Spatiotemporal distribution and environmental influences of severe fever with thrombocytopenia syndrome in Shandong Province, China

Duan,

Tian,

Pang

et al. 2023

BMC Infect Dis

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Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in China in 2009. The purpose of this study was to describe the spatiotemporal distribution of SFTS and to identify its environmental influencing factors and potential high-risk areas in Shandong Province, China. Methods Data on the SFTS incidence from 2010 to 2021 were collected. Spatiotemporal scan statistics were used to identify the time and area of SFTS clustering. The maximum entropy (MaxEnt) model was used to analyse environmental influences and predict high-risk areas. Results From 2010 to 2021, a total of 5705 cases of SFTS were reported in Shandong. The number of SFTS cases increased yearly, with a peak incidence from April to October each year. Spatiotemporal scan statistics showed the existence of one most likely cluster and two secondary likely clusters in Shandong. The most likely cluster was in the eastern region, from May to October 2021. The first secondary cluster was in the central region, from May to October 2021. The second secondary cluster was in the southeastern region, from May to September 2020. The MaxEnt model showed that the mean annual wind speed, NDVI, cattle density and annual cumulative precipitation were the key factors influencing the occurrence of SFTS. The predicted risk map showed that the area of high prevalence was 28,120 km2, accounting for 18.05% of the total area of the province. Conclusions The spatiotemporal distribution of SFTS was heterogeneous and influenced by multidimensional environmental factors. This should be considered as a basis for delineating SFTS risk areas and developing SFTS prevention and control measures.

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Seroepidemiological study of severe fever with thrombocytopenia syndrome in animals and humans in Okinawa, Japan

Cited by 7 publications

References 30 publications

Severe Fever with Thrombocytopenia Syndrome Virus RNA in Ticks from Wild Mongooses in Okinawa Prefecture, Japan

Severe Fever with Thrombocytopenia Syndrome Virus RNA in Ticks from Wild Mongooses in Okinawa Prefecture, Japan

Vectors, Hosts, and the Possible Risk Factors Associated with Severe Fever with Thrombocytopenia Syndrome

Spatiotemporal distribution and environmental influences of severe fever with thrombocytopenia syndrome in Shandong Province, China

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