Seroepidemiological study of <i>Helicobacter pylori</i> infection in asymptomatic people in South Korea

Kim, Jin Ho; Kim, Hak Yang; Kim, Na Young; Kim, Sang Woo; Kim, Jae Gyu; Kim, Jae Jun; Roe, Im Hwan; Seo, Jeong Kee; Sim, Jae Geon; Ahn, Hyoengsik; Yoon, Byung Chul; Lee, Sang Woo; Lee, Yong Chan; Chung, In Sik; Jung, Hwoon Yong; Hong, Weon Seon; Choi, Kyoo Wan

doi:10.1046/j.1440-1746.2001.02568.x

Cited by 149 publications

(109 citation statements)

References 41 publications

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“…Comparison of Helicobacter pylori seropositivity with previous data 7, 8, 9 in asymptomatic adult participants in South Korea…”

Section: Resultsmentioning

confidence: 90%

“…We compared the H. pylori seropositivity of asymptomatic participants among the 1998, 2005, and 2011 studies7, 8, 9 and this study. The overall seropositivity of 51.0% (95% CI: 49.6‐52.4%) in this study represented a significant decrease from 66.9% (95% CI: 65.4‐68.6%) in 1998, 59.6% (95% CI: 58.5‐60.7%) in 2005, and 54.4% (95% CI: 53.5‐55.4%) in 2011 ( P < .001) (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Multivariable logistic regression was used for the investigation of risk factors for H. pylori seropositivity. We used the Cochran‐Armitage trend test for the comparison of H. pylori seroprevalence among the data published in 1998,7 2005,8 2011,9 and in this study. We only analyzed the results of asymptomatic participants from previous studies.…”

Section: Methodsmentioning

confidence: 99%

“…Accordingly, determination of the H. pylori prevalence of normal asymptomatic participants is crucial for the establishment of national health policies in these Eastern Asia countries. Nationwide studies of H. pylori prevalence were performed in Korea in 1998, 2005, and 2011 7, 8, 9. Although these studies obtained data from a large number of participants, they had several notable limitations, such as inconsistencies in test methods, uneven study populations, and lack of socioeconomic information.…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

et al. 2018

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BackgroundThe Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables.MethodsWe planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H. pylori serum IgG using a chemiluminescent enzyme immunoassay.ResultsWe analyzed 4917 samples (4917/4920 = 99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the H. pylori seropositivity rate was 51.0% (2414/4734). We verified a decrease in H. pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (P < .0001). The H. pylori seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40 years (38.1% in those aged 30‐39 years and 57.7% in those aged 40‐49 years) and was lower in city residents than in noncity residents at all ages.Conclusions Helicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H. pylori‐related policies.

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“…Comparison of Helicobacter pylori seropositivity with previous data 7, 8, 9 in asymptomatic adult participants in South Korea…”

Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

et al. 2018

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“…1 About 60% of Korean adults are infected with Helicobacter pylori (H. pylori). 2,3 This is regarded as a leading cause of gastric carcinogenesis and is associated with a 2-fold increased risk of developing gastric adenocarcinomas. 4,5 However, H. pylori infection is associated with divergent clinical outcomes, ranging from simple asymptomatic gastritis to more serious conditions such as peptic ulcer disease and gastric neoplasia.…”

mentioning

confidence: 99%

Interleukin‐1B (IL‐1B) polymorphisms and gastric mucosal levels of IL‐1β cytokine in Korean patients with gastric cancer

Chang

Jang

Kim

et al. 2004

Intl Journal of Cancer

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Interleukin-1B and IL-1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL-1B-511T polymorphism and the risk of GC in Asians. We tested for an association between IL-1 loci polymorphisms with increased gastric mucosal levels of IL-1␤ and an increased risk of developing GC in a Korean population. Polymorphisms of IL-1A-889, IL-1B-31, IL-1B-511 and IL-1RN were genotyped in 434 controls and 234 patients with GC. Mucosal IL-1␤ cytokine was measured using an ELISA. The frequencies of IL-1A, IL-1B-511, IL-1B-31 and IL-1RN were not statistically different between controls and all patients with GC. After subclassification of GC, only patients with intestinal-type GC showed a higher frequency of IL-1B-31T homozygotes (OR ‫؍‬ 2.2; 95% CI ‫؍‬ 1.1-4.3) compared with controls. Risk was also significantly increased in these patients for IL-1B-31T homozygotes compared with patients with diffuse-type GC (OR ‫؍‬ 3.4; 95% CI ‫؍‬ 1.5-7.7). As in Caucasian populations, linkage disequilibrium between IL-1B-31 and IL-1B-511 was nearly complete, but the pattern of haplotype related to the risk of GC (IL-1B-31T/IL-1B-511C) was opposite (IL-1B-511T/IL-1B-31C). Mucosal IL-1␤ levels in H. pylori-infected GC patients were higher in patients homozygous for IL-1B-31T compared with IL-1B-31C/T and IL-1B-31C/C. Thus, the combined effects of H. pylori infection and IL-1B-31T/IL-1B-511C polymorphisms with enhanced mucosal IL-1␤ production contributed to the development of intestinal-type GC in this Korean population.

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Unique side chain conformation of a leu residue in a triple‐helical structure

et al. 2007

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Single crystal structures of host-guest peptides, (Pro-Hyp-Gly)(4)-Leu-Hyp-Gly-(Pro-Hyp-Gly)(5) (LOG1) and (Pro-Hyp-Gly)(4)- (Leu-Hyp-Gly)(2)-(Pro-Hyp-Gly)(4) (LOG2), have been determined at 1.6 A and 1.4 A resolution, respectively. In these crystals, the side chain conformations of the Leu residues were (+)gauche-trans. This conformational preference for the Leu side chain in the Leu-Hyp-Gly sequence was explained by stereochemical considerations together with statistical analysis of Protein Data Bank data. In the (+)gauche-trans conformation, the Leu side chain can protrude along the radial direction of the rod-like triple-helical molecule. One strong hydrophobic interaction of the Leu residue was observed between adjacent molecules in the LOG2 crystal. Because the Leu-Hyp-Gly sequence is one of the most frequently occurring triplets in Type I collagen, this strong hydrophobic interaction can be expected in a fibrillar structure of native collagen. All the Leu residues in the asymmetric unit of the LOG1 and LOG2 crystals had water molecules hydrogen bonded to their NH. These water molecules made three additional hydrogen bonds with the Hyp OH, the Gly O[double bond]C, and a water molecule in the second hydration shell, forming a tetrahedral coordination of hydrogen bonds, which allows a smaller mean-square displacement factor of this water oxygen atom than those of other water molecules. These hydrogen bonds stabilize the molecular and packing structures by forming one O[double bond]C(Gly)---W---OH(Hyp) intra-molecular linkage and two NH(Leu)---W---O[double bond]C(Gly) and NH(Leu)---W---OH(Hyp) inter-molecular linkages.

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Seroepidemiological study of Helicobacter pylori infection in asymptomatic people in South Korea

Abstract: This nation-wide seroprevalence of H. pylori infection in South Korea was 46.6%, which showed the transition from a developing country to a developed country. More studies on the epidemiological factors and the route of transmission of H. pylori infection should be warranted.

Cited by 149 publications

References 41 publications

Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

Interleukin‐1B (IL‐1B) polymorphisms and gastric mucosal levels of IL‐1β cytokine in Korean patients with gastric cancer

Unique side chain conformation of a leu residue in a triple‐helical structure

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