Serodynamics Of Treponema Pallidum In Serum Of Pregnant Women In Benin City

Ibadin, KO; Enabulele, OI; Eghafona, N. O.; Osemwenkha, AP

doi:10.4314/bjpm.v11i1.48842

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Similarly, the 1.0% reported among the sexuallyactive hospital attendees are comparable to the 1.1% reported in Osogbo, Nigeria [19]. Whereas it is lower than the 1.5% and 1.7% recorded in Benin and Ilorin, respectively [22][23] as well as 1.42% reported in the rural area of Akwa Ibom State, Nigeria [9] but is higher than the 0.1% reported by Ejele et al [24] in Port Harcourt, Nigeria and 0.4%, recorded in Yola [25].…”

Section: Discussionsupporting

confidence: 50%

Detection of Treponema pallidum (Syphilis) Antibodies among HIV-Infected Individuals and Sexually-active Attendees of Two Health Facilities in Port Harcourt, Nigeria

Okonko

Cookey

Adewuyi-Oseni

et al. 2020

I-SRR

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Aim: This study reports on the detection of Treponema pallidum (syphilis) antibodies in HIV infected patients in Port Harcourt, Nigeria. Screening for syphilis was carried out to determine the prevalence levels of these infections, as biological markers of risk, modes, and time functions of their transmission. Study Design: Cross-sectional study. Place and Duration of Study: University of Port Harcourt Teaching Hospital (UPTH) and O.B. Lulu Briggs Medical Centre, University of Port Harcourt, both in Port Harcourt, Nigeria, between August 2012 and July 2015. Methods: A total of 100 HIV-infected individuals and 100 sexually-active attendees were recruited for this study. Samples of blood were collected and re-screened for the presence of HIV antibodies using the Determine HIV-1/2 (Alere), HIV ½ Stat-Pak (Chembio), and HIV-1/2/P24/O ELISA kit (Dia.Pro). The same set of samples were screened for Treponema pallidum specific antibodies using the syphilis Ultra Rapid Test Strip (ACON(R), USA) and syphilis rapid strips (Global, USA) following the respective manufacturer's instructions. Results: Among the 200 samples, serological reactivity was detected for syphilis in 3(1.5%). The incidence of syphilis was higher in males (2.0%) than in females (1.0%). Age, sex, and locality did not significantly (P>0.05) influence the rate of syphilis. Conclusion: This study further confirms the presence of syphilis among the population studied. Routine screening of Syphilis among patients is therefore advocated.

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Section: Discussionsupporting

confidence: 50%

Detection of Treponema pallidum (Syphilis) Antibodies among HIV-Infected Individuals and Sexually-active Attendees of Two Health Facilities in Port Harcourt, Nigeria

Okonko

Cookey

Adewuyi-Oseni

et al. 2020

I-SRR

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“…18 It is also comparable to 1.7%, 1.5%, and 0.4% reported in other parts of Nigeria. [19][20][21] However, it is lower than 5.0% and 10.0%. reported by other authors in south-south and south-west Nigeria respectively.…”

Section: Discussionmentioning

confidence: 89%

Comparative assessment of veneral disease research laboratory (VDRL) and point of care (POC) tests for diagnosing syphilis among pregnant women at a tertiary health facility in Lagos: A retrospective cohort study

Harrison,

Ugwu,

Okunade

et al. 2023

HJOG

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Background: Syphilis is a systemic infection caused by the Spirochete Treponema Pallidum. The infection is of particular concern during pregnancy because of the high risk of vertical transmission causing adverse outcome including death. Traditional screening method is with Venereal Disease Research Laboratory (VDRL), which has a high false positive result and an increased waiting time. Aim: To compare the syphilis detection rate between Point-of-Care testing and Venereal Disease Research Laboratory testing among pregnant women. Methods: The retrospective cohort study was conducted at 68 Nigerian Army Reference Hospital Yaba (68NARHY), Lagos between July 2021 and June 2023. Data from antenatal clinic records were retrieved. All eligible pregnant women had both POC and VDRL testing. The primary outcome measures were false positive, false negative, true positive, true negative of the two tests. The sensitivity, and specificity and the diagnostic accuracy of both tests were calculated following which the ROC curve was drawn. Women with incomplete record or who did not conduct both testing were excluded from the study. All data set were collected using a well-designed purpose driven proforma. The data set were stored and later analyzed using the IBM SPSS for Windows, version 26.0 Armonk, NY: IBM corp. Analysis was both descriptive and inferential. The p-value of < 0.05 was set as statistically significant levels. Result: The mean age of the participants was 31.30±5.3. About 45.5% were of low parity while military personnel consisted of more than half of the study population. The prevalence of syphilis was 1.8% and 4.3% using VDRL and POC test kits respectively. When compared, there was a significant difference (P<0.001). It was also noted that a greater proportion of military personnel were reactive to the screening using either of those kits as against civilians. Conclusion: In our study, POC has demonstrated its ability to detect more cases of syphilis than VDRL as a screening test. Therefore, POC may serve as a cost-effective replacement screening test for VDRL, to rapidly and accurately detect syphilis infection. This step is crucial for early diagnosis, prompt treatment, and the prevention of further transmission of syphilis.

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“…The [20,21]. Similarly, it is higher than the 0.4%, 1.5% and 1.7% recorded in Yola, Benin and Ilorin, respectively [22,23,24]. It is however lower than the 5.0% and 10.0% reported in Yenagoa and Osogbo, respectively [25,26].…”

Section: Methodsmentioning

confidence: 96%

Overview of Prevalence of Syphilis in a Health Facility in Rivers State

Azuonwu¹,

Timothy²

2020

I-SRR

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Syphilis is one of the sexually transmitted diseases that is prevalent in developing countries and is of public health importance. Among pregnant women, it is reported to cause foetal defects if not treated. This study was thus carried out to determine the prevalence of syphilis among pregnant women visiting a health facility in Rivers State. Records of 482 pregnant women who visited the health facility within January and December 2018 were reviewed after obtaining due consent from the relevant authority. The sensitivity rate of the RPR test was higher than the THPA test, however the THPA has been found to be more specific. A prevalence rate of 2.28% was reported among the samples collected. The women who tested positive had little or no formal education which may have contributed to low knowledge of the disease. Intensive public health awareness on the means of transmission, symptoms, signs and effects of contracting the disease, especially among pregnant women should be carried out. Also, robust screening should be carried out at the community level in order to have proper record of the number of persons infected. Rapid test kits that are reliable should be made available also.

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Serodynamics Of Treponema Pallidum In Serum Of Pregnant Women In Benin City

Cited by 3 publications

References 7 publications

Detection of Treponema pallidum (Syphilis) Antibodies among HIV-Infected Individuals and Sexually-active Attendees of Two Health Facilities in Port Harcourt, Nigeria

Detection of Treponema pallidum (Syphilis) Antibodies among HIV-Infected Individuals and Sexually-active Attendees of Two Health Facilities in Port Harcourt, Nigeria

Comparative assessment of veneral disease research laboratory (VDRL) and point of care (POC) tests for diagnosing syphilis among pregnant women at a tertiary health facility in Lagos: A retrospective cohort study

Overview of Prevalence of Syphilis in a Health Facility in Rivers State

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