Serodiagnosis Of Mycobacterium Avium Complex Pulmonary Disease In The United States

Changes in Serum IgA Antibody Levels against the Glycopeptidolipid Core Antigen during Antibiotic Treatment of <i>Mycobacterium avium</i> Complex Lung Disease

“…Based on a recommended IgA cutoff value of 0.7 U mL (4,5), 50 (88 ) of these patients were seropositive for MAC lung disease and 7 (12 ) were seronegative for this disease. The serum anti-GPL IgA levels at T0 (median 3.50 U mL), T3 (median 2.71 U mL), and T6 (median 2.61 U mL) were significantly decreased in the 57 patients following antibiotic treatment (P ＜ 0.001), and ;…”

Lady Windermere syndrome

“…An enzyme immunoassay (EIA) test that detects serum anti-glycopeptidolipid (GPL) core IgA antibody has sensitivity and specificity ranging from 70.1%-81.3% and 88.3%-93.9%. 76,77 Recent studies show that real-time PCR is 71.1%-100% sensitive for detecting M. avium in a sputum sample depending on the assay. [78][79][80] In addition, realtime PCR takes only two hours to confirm a diagnosis compared to eight days needed to detect M. avium in liquid culture and can provide early detection of antibiotic resistance of an M. avium isolate to clarithromycin at known alleles.…”

Serodiagnosis of Mycobacterium avium Complex Disease in Humans: Translational Research from Basic Mycobacteriology to Clinical Medicine

“…To extend the usefulness of EIA kit for MAC-GPL internationally, I have compared cut-off level, sensitivity and specificity among Japan, USA, and Taiwan (Table 3). The performance in Taiwan (sensitivity: 61z, specificity: 91z) (13) was relatively low when compared to Japan (sensitivity: 84z, specificity: 100z) (11) and USA (sensitivity: 77z, specificity: 94z) (14). Possible reasons for low sensitivity and specificity in Taiwan include relatively high incidence of diseases due to rapidly growing mycobacteria possessing GPL and study population contains immunocompromised hosts, although studies in Japan and USA employed sera of patients with im- munocompetent MAC-PD.…”