Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde

Ward, Daniel; Gomes, Ana; Tetteh, Kevin K. A.; Sepúlveda, Nuno; Goméz, Lara Ferrero; Campino, Susana; Clark, Taane G.

doi:10.1038/s41598-022-16115-4

Cited by 5 publications

(4 citation statements)

References 39 publications

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“…Seroprevalence studies were conducted in 49 countries and territories, with a total of 63,864 individuals involved. These studies comprised 18 countries in Africa (including Burkina Faso [ 8 ], Cape Verde [ 9 ], Cameroon [ 10 ], Democratic Republic of the Congo [ 11 ], Ethiopia [ 12 ], Gabon [ 13 ], Ghana [ 14 ], Kenya [ 15 , 16 ], Madagascar [ 17 ], Mali [ 18 , 19 ], Nigeria [ 20 – 24 ], Republic of the Congo [ 25 ], Rwanda [ 26 ], Senegal [ 18 ], Sudan [ 27 ], Tanzania [ 28 ], The Gambia [ 18 ], and Zambia [ 29 , 30 ]); 13 countries in the Americas (Bolivia [ 1 ], Brazil, Colombia, French Guiana (see references in S2 Table ), Guatemala [ 31 ], Honduras [ 32 ], Jamaica [ 33 ], Martinique [ 34 ], Mexico [ 32 , 35 ], Nicaragua (references in S2 Table ), Peru [ 36 ], Puerto Rico [ 32 ], and Suriname [ 37 ]); 3 countries in the Eastern Mediterranean (Iran [ 38 ], Iraq [ 39 ], Saudi Arabia [ 40 ]); 3 countries in Europe (Cyprus [ 41 ], France [ 42 ] and Sweden [ 26 ]); 2 countries in Southeast Asia (Indonesia, Thailand (references in S2 Table ); and 10 countries in the Western Pacific region (China [ 43 – 45 ], Fiji […”

Section: Resultsmentioning

confidence: 99%

Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review

Saba Villarroel,

Hamel,

Gumpangseth

et al. 2024

PLoS Negl Trop Dis

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Background Zika virus (ZIKV) has spread to five of the six World Health Organization (WHO) regions. Given the substantial number of asymptomatic infections and clinical presentations resembling those of other arboviruses, estimating the true burden of ZIKV infections is both challenging and essential. Therefore, we conducted a systematic review and meta-analysis of seroprevalence studies of ZIKV IgG in asymptomatic population to estimate its global impact and distribution. Methodology/Principal findings We conducted extensive searches and compiled a collection of articles published from Jan/01/2000, to Jul/31/2023, from Embase, Pubmed, SciELO, and Scopus databases. The random effects model was used to pool prevalences, reported with their 95% confidence interval (CI), a tool to assess the risk of study bias in prevalence studies, and the I2 method for heterogeneity (PROSPERO registration No. CRD42023442227). Eighty-four studies from 49 countries/territories, with a diversity of study designs and serological tests were included. The global seroprevalence of ZIKV was 21.0% (95%CI 16.1%-26.4%). Evidence of IgG antibodies was identified in all WHO regions, except for Europe. Seroprevalence correlated with the epidemics in the Americas (39.9%, 95%CI:30.0–49.9), and in some Western Pacific countries (15.6%, 95%CI:8.2–24.9), as well as with recent and past circulation in Southeast Asia (22.8%, 95%CI:16.5–29.7), particularly in Thailand. Additionally, sustained low circulation was observed in Africa (8.4%, 95%CI:4.8–12.9), except for Gabon (43.7%), and Burkina Faso (22.8%). Although no autochthonous transmission was identified in the Eastern Mediterranean, a seroprevalence of 16.0% was recorded. Conclusions/Significance The study highlights the high heterogeneity and gaps in the distribution of seroprevalence. The implementation of standardized protocols and the development of tests with high specificity are essential for ensuring a valid comparison between studies. Equally crucial are vector surveillance and control methods to reduce the risk of emerging and re-emerging ZIKV outbreaks, whether caused by Ae. aegypti or Ae. albopictus or by the Asian or African ZIKV.

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Section: Resultsmentioning

confidence: 99%

Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review

Saba Villarroel,

Hamel,

Gumpangseth

et al. 2024

PLoS Negl Trop Dis

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show abstract

“…This could have occurred because the commercial serological cut-off was used rather than any population-specific alternative derived from the observed antibody responses. While the appropriateness of cut-offs were assessed visually, the sample size for this study was not considered large enough to undertake mixture modelling [ 25 , 26 ]. Furthermore, virus neutralisation assays may have been more accurate in determining dengue serostatus (and could correlate better with outcomes after Dengvaxia) than ELISAs [ 12 , 22 ], however they were not available during this study which took place in Timor-Leste.…”

Section: Discussionmentioning

confidence: 99%

Field evaluation of rapid diagnostic tests to determine dengue serostatus in Timor-Leste

et al. 2022

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The live attenuated tetravalent CYD-TDV vaccine (Dengvaxia) is effective but has scarcely been used due to safety concerns among seronegative recipients. Rapid diagnostic tests (RDTs) which can accurately determine individual dengue serostatus are needed for use in pre-vaccination screening. This study aimed to determine the performance of existing RDTs (which have been designed to detect levels of immunoglobulin G, IgG, associated with acute post-primary dengue) when repurposed for detection of previous dengue infection (where concentrations of IgG are typically lower). A convenience sample of four-hundred-and-six participants (including 217 children) were recruited in the community. Whole blood was collected by phlebotomy and tested using Bioline Dengue IgG/IgM (Abbott) and Standard Q Dengue IgM/IgG (SD Biosensor) RDTs in the field. Serum samples from the same individuals were also tested at National Health Laboratory. The Panbio indirect IgG ELISA was used as a reference test. Reference testing determined that 370 (91.1%) participants were dengue IgG seropositive. Both assays were highly specific (100.0%) but had low sensitivity (Bioline = 21.1% and Standard Q = 4.6%) when used in the field. Sensitivity was improved when RDTs were used under laboratory conditions, and when assays were allowed to run beyond manufacturer recommendations (and read at a delayed time-point), but specificity was reduced. Efforts to develop RDTs with high sensitivity and specificity for prior dengue infection which can be operationalised for pre-vaccination screening are ongoing. Performance of forthcoming candidate assays should be tested under field conditions with blood samples, as well as in the laboratory.

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“…Culex and Culiseta are vectors of tularemia, as well as arbovirus infections such as the West Nile virus (Muslu et al, 2011). The recent outbreak of mosquitoborne arbovirus which is of global health concern is the Zika virus transmitted by Aedes mosquitoes (Sejvar, 2018;Ward et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

A study on mosquitoes composition and malaria transmission in some communities in Doma Local Government Area of Nasarawa State, Nigeria

Osidoma,

Pam,

Uzoigwe

et al. 2023

J. Biosci. Biotechnol. Discov.

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The paucity of information on malaria vectors in rural areas continues to pose a problem in the public health sector in Nigeria. Thus, the study on mosquitoes composition and malaria transmission in some communities in Doma Local Government Area (LGA) of Nasarawa State, Nigeria was carried out between April and July 2021. Indoor resting mosquitoes were collected using standard pyrethrum spray catch (PSC) from 0600 to 0900 hours. The mosquitoes collected were transferred into a well labelled petri-dish and transported to the laboratory for processing. A total of 1,317 mosquitoes were collected which spread across Iwashi 1,132 (85.9%) and Ruttu 185 (14.0%) communities. The results obtained indicate that the Anopheles mosquitoes had a higher abundance of 1,020 (77.4%) mosquitoes of which females constituted 886 (67.3%) of the population collected while the anopheline males accounted for 134 (10.2%). The abundance of mosquitoes in relation to groups, species and sex respectively varied significantly (p < 0.05). A zero (0.0%) sporozoite rate was recorded from the 654 female Anopheles gambiae s. l. dissected, although oocyst was seen in the alimentary canal of 78 (11.9%) mosquitoes which may be an indicator of possible potential transmission. The results obtained from this study call on all the inhabitants of the two selected communities as well as Doma LGA at large to always clear all potential mosquitoes breeding sites. Also, members of the communities should ensure proper protection against vector-human contact by sleeping under insecticide treated bed nets.

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Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde

Cited by 5 publications

References 39 publications

Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review

Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review

Field evaluation of rapid diagnostic tests to determine dengue serostatus in Timor-Leste

A study on mosquitoes composition and malaria transmission in some communities in Doma Local Government Area of Nasarawa State, Nigeria

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