Serious Thrombocytopenia Due to Dengue Hemorrhagic Fever Treated with High Dosages of Immunoglobulin

Ostronoff, M; Ostronoff, Fabiana; Florêncio, Rodrigo; Florencio, Maria Lourdes; Domingues, Mariana; Calixto, Rodolfo; Sucupira, Alexandre; Maior, Ana Patricia Souto; Matias, C.; Matias, Kleber; Tagliari, C.; Soussain, Carole

doi:10.1086/374870

Cited by 24 publications

(13 citation statements)

References 3 publications

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“…Ostronoff et al suggested a therapeutic benefit of gamma globulins in severe thrombocytopenia in DHF. This was not evaluated in pregnant women [46]. Eight patients received intensive care management, but occasional non-availability of beds affected admission to an intensive care unit.…”

Section: Resultsmentioning

confidence: 99%

Dengue infections during pregnancy: case series from a tertiary care hospital in Sri Lanka

Kariyawasam¹,

Senanayake²

2010

J Infect Dev Ctries

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Introduction: Dengue is the most important mosquito-borne disease in Sri Lanka, leading to more than 340 deaths during the last outbreak (≈35,000 reported cases) starting in mid April 2009. The predominant dengue virus serotypes during the last few years have been DENV-2 and DENV-3. Dengue infection in pregnancy carries the risk of hemorrhage for both the mother and the newborn. Other risks include premature birth, fetal death, and vertical transmission. We report clinical and laboratory findings and outcomes in pregnant women hospitalized with dengue infection during pregnancy. Methodology: Clinical, laboratory, maternal/fetal outcomes and demographic data were collected from patients with confirmed dengue infections during pregnancy treated at De Soysa Maternity Hospital, Sri Lanka from 1 May 2009 to 31 December 2009. Results: Fifteen seropositive dengue infected pregnant women were diagnosed in the period. Multiorgan failure leading to intrauterine fetal and maternal death occurred in one case of dengue hemorrhagic fever (DHF) IV. One patient with DHF III had a miscarriage at the 24 th week of gestation. Perinatal outcomes of the other cases were satisfactory. One woman developed dengue myocarditis but recovered with supportive treatments. No cases of perinatal transmission to the neonate occurred. Conclusion: Dengue in pregnancy requires early diagnosis and treatment. A high index of clinical suspicion is essential in any pregnant woman with fever during epidemic. Further studies are mandatory as evidence-based data in the management of dengue specific for pregnancy are sparse.

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Section: Resultsmentioning

confidence: 99%

Dengue infections during pregnancy: case series from a tertiary care hospital in Sri Lanka

Kariyawasam¹,

Senanayake²

2010

J Infect Dev Ctries

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“…Thrombocytopenia is thought to be due to suppression of bone marrow observed in acute phase of dengue [9]. Other explanation includes direct infection of megakaryocytes, presence of antibodies against platelets and release of high levels of platelet activating factor by monocytes [13].…”

Section: Discussionmentioning

confidence: 99%

Plasmacytoid Lymphocytes: A Diagnostic clue to Dengue Infection

2016

IJSR

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“…Corticosteroids and intravenous immunoglobulin (IVIG) seem effective in reversing thrombocytopenia and improving clinical outcome. [7][8][9] An animal study suggested that IVIG exerts its rapid effect in reversing thrombocytopenia by inhibiting reticuloendothelial system function. 10 It may be assumed that immunosuppressants, such as IVIG and corticosteroids, may be effective in treating dengue fever complicated by ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%