Serious Neurological Adverse Events of Ceftriaxone

Lacroix, Clémence; Bera-Jonville, Annie-Pierre; Montastruc, François; Velly, Lionel; Micallef, Joëlle; Guilhaumou, Romain

doi:10.3390/antibiotics10050540

Cited by 19 publications

(26 citation statements)

References 50 publications

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“…The probability of neurotoxicity of cefotaxime or ceftriaxone is lower than in the above-mentioned group [27], although the study of Lacroix et al reported the incidence of serious CNS complications associated with ceftriaxone therapy to be seven times higher than that published in the literature. Reported CNS ADRs between 1995 and 2017 identified ceftriaxone as both the leading cause of hospitalization and life-threatening situations, or even death [81].…”

Section: Beta-lactamsmentioning

confidence: 99%

Antibiotics and the Nervous System—Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)?

2021

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Antibiotics as antibacterial drugs have saved many lives, but have also become a victim of their own success. Their widespread abuse reduces their anti-infective effectiveness and causes the development of bacterial resistance. Moreover, irrational antibiotic therapy contributes to gastrointestinal dysbiosis, that increases the risk of the development of many diseases, including neurological and psychiatric. One of the potential options for restoring homeostasis is the use of oral antibiotics that are poorly absorbed from the gastrointestinal tract (e.g., rifaximin alfa). Thus, antibiotic therapy may exert neurological or psychiatric adverse drug reactions which are often considered to be overlooked and undervalued issues. Drug-induced neurotoxicity is mostly observed after beta-lactams and quinolones. Penicillin may produce a wide range of neurological dysfunctions, including encephalopathy, behavioral changes, myoclonus or seizures. Their pathomechanism results from the disturbances of gamma-aminobutyric acid-GABA transmission (due to the molecular similarities between the structure of the β-lactam ring and GABA molecule) and impairment of the functioning of benzodiazepine receptors (BZD). However, on the other hand, antibiotics have also been studied for their neuroprotective properties in the treatment of neurodegenerative and neuroinflammatory processes (e.g., Alzheimer’s or Parkinson’s diseases). Antibiotics may, therefore, become promising elements of multi-targeted therapy for these entities.

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Section: Beta-lactamsmentioning

confidence: 99%

Antibiotics and the Nervous System—Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)?

2021

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“…In a recent report, Lacroix et al [ 16 ] used the French pharmacovigilance database to analyze records of CNS adverse events due to CTRX that were recorded as occurring in 1995–2017. A total of 152 serious adverse drug reactions (ADRs) were analyzed: 112 resulted in hospitalization or prolonged hospitalization (73.7%), 12 resulted in death (7.9%), and 16 were life-threatening.…”

Section: Tdm Of Ceftriaxonementioning

confidence: 99%

Importance and Reality of TDM for Antibiotics Not Covered by Insurance in Japan

Ebihara

Hamada

Kato

et al. 2022

IJERPH

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Under the Japanese health insurance system, medicines undergoing therapeutic drug monitoring (TDM) can be billed for medical fees if they meet the specified requirements. In Japan, TDM of vancomycin, teicoplanin, aminoglycosides, and voriconazole, which are used for the treatment of infectious diseases, is common practice. This means the levels of antibiotics are measured in-house using chromatography or other methods. In some facilities, the blood and/or tissue concentrations of other non-TDM drugs are measured by HPLC and are applied to treatment, which is necessary for personalized medicine. This review describes personalized medicine based on the use of chromatography as a result of the current situation in Japan.

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“…In a recent report, Lacroix et al [15] used the French pharmacovigilance database to analyze records of CNS adverse events due to CTRX that were recorded as occurring in 1995-2017. A total of 152 serious adverse drug reactions (ADRs) were analyzed: 112 resulted in hospitalization or prolonged hospitalization (73.7%), 12 resulted in death (7.9%), and 16 were life-threatening.…”

Section: Characteristics Of Ceftriaxone and Significance Of Tdmmentioning

confidence: 99%

Potential Clinical Benefits of TDM of Antimicrobials in Japan

Ebihara¹,

Hamada²,

Maruyama³

et al. 2022

Preprint

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Under the Japanese health insurance system, medicines undergoing therapeutic drug monitoring (TDM) can be billed for medical fees if they meet the specified requirements. In Japan, TDM of vancomycin, teicoplanin, aminoglycosides, and voriconazole, which are used for the treatment of infectious diseases, is common practice. This means the levels of antimicrobial agents are measured in-house using chromatography. This review describes personalized medicine based on the use of chromatography as a result of the current situation in Japan.

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Serious Neurological Adverse Events of Ceftriaxone

Cited by 19 publications

References 50 publications

Antibiotics and the Nervous System—Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)?

Antibiotics and the Nervous System—Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)?

Importance and Reality of TDM for Antibiotics Not Covered by Insurance in Japan

Potential Clinical Benefits of TDM of Antimicrobials in Japan

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