Serious Limitation of Preimplantation Genetic Diagnosis

Nishimura, Takayo; Sasabe, Yutaka; Shibui, Yukihiro; Ito, Kanako; Katagiri, Yuki; Masaki, Kazuo; Abe, Yuji; Kubo, Harumi

doi:10.1274/jmor.19.1

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Means Of Overcoming Disadvantages (2)2

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2003

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“…We reported PGD by means of two-step FISH for chromosome-X, Y, 13, 16, 18, 21 and 22 [16]. Gianaroli et al [17] reported that screening for chromosome-X, Y, 13,14,15,16,18, 21 and 22 has an immediate impact on implantation rate.…”

Section: Means Of Overcoming Disadvantages (2)mentioning

confidence: 99%

“…Two days are made available for diagnosis. The sufficient time for diagnosis makes it possible to attempt to obtain information on all chromosomes, such as visualization of metaphase plates or in vitro culture of single biopsied blastomeres [18]. Although PGD to screen chromosomal abnormalities on embryos is invasive and is not permitted in Japan, the combination of PGD and BT will make it possible to transfer blastocysts without chromosomal abnormalities.…”

Section: Means Of Overcoming Disadvantages (2)mentioning

confidence: 99%

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