Serious Hazards of Transfusion: A Decade of Hemovigilance in the UK

Stainsby, D; Jones, H; Asher, Deborah; Atterbury, Colin E.; A, Boncinelli; Brant, L. J.; Chapman, C.; Davison, Katy; Gerrard, Rebecca; Gray, Alexandra; Knowles, S; Love, Elizabeth M.; Milkins, Clare; McClelland, D. B. L.; Norfolk, D. R.; Soldan, Kate; Taylor, Clare; Revill, John; Williamson, Lorna M.; Cohen, Hannah

doi:10.1016/j.tmrv.2006.05.002

Cited by 294 publications

(246 citation statements)

References 12 publications

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“…Moreover, the lack of transfusion related complications in our sample reinforces the experience of Stainsby et al (2006), according to whom the most frequent problem of blood transfusion is human error. Other authors (Ademokun et al, 2005) have reported that transfusions at home are probably more checked with the potential for fewer mistakes as compared with those occurring in the setting of a busy hospital.…”

Section: Discussionsupporting

confidence: 80%

Home management of hematological patients requiring hospital admission

Isaia

Tibaldi

Astengo

et al. 2010

Archives of Gerontology and Geriatrics

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Section: Discussionsupporting

confidence: 80%

Home management of hematological patients requiring hospital admission

Isaia

Tibaldi

Astengo

et al. 2010

Archives of Gerontology and Geriatrics

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“…It has been thanks to the British Serious Hazards of Transfusion (SHOT) haemovigilance system that the recognition of TRALI has gained increased recognition. In recent years, TRALI has been reliably shown to be the most common cause of transfusion-related fatalities in the United States and in the United Kingdom (Holness et al, 2004;Stainsby et al, 2004). This review summarises the current knowledge on the pathogenesis of TRALI.…”

Section: Discussionmentioning

confidence: 99%

The pathogenesis of transfusion‐related acute lung injury (TRALI)

2007

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SummaryIn recent years, transfusion-related acute lung injury (TRALI) has developed from an almost unknown transfusion reaction to the most common cause of transfusion-related major morbidities and fatalities. A clinical definition of TRALI was established in 2004, based on acute respiratory distress, noncardiogenic lung oedema temporal association with transfusion and hypoxaemia. Histological findings reveal lung oedema, capillary leucostasis and neutrophil extravasation. However, the pathogenesis of TRALI remains controversial. Leucocyte antibodies, present in fresh frozen plasma and platelet concentrates from multiparous donors, and neutrophil priming agents released in stored cellular blood components have been considered to be causative. As neutrophils and endothelial cells are pivotal in the pathogenesis of TRALI, a threshold model was established to try to unify the various reported findings on pathogenesis. This model comprises the priming of neutrophils and/or endothelium by the patient's co-morbidity, neutrophil and/or endothelial cell activation by the transfused blood component, and the severity of the TRALI reaction.

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“…[1][2][3][4] TRALI is defined as the acute onset of hypoxia and bilateral pulmonary infiltrates, in temporal relation to a blood transfusion. 1,5 Although the absence of specific disease markers and diagnostic tests has resulted in a large variation in estimations of incidence, 1,[6][7][8][9][10][11][12][13][14] TRALI is generally considered to be a rare event.…”

Section: Introductionmentioning

confidence: 99%