Serious generalized tonic–clonic seizures induced by aripiprazole

Lin, Ko-Huan; Chen, Yu-Jung; Lin, Yueh-Tzeng; Hsueh, Wen-Chie; Lu, Chao; Yen, Ming-Hang; Liao, Kun-Chu

doi:10.1016/j.pnpbp.2009.08.025

Cited by 6 publications

(6 citation statements)

References 4 publications

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“…Aripiprazole is a partial D2 agonist and an antagonist/partial agonist of 5-HT2 receptors [90]. Aripiprazole has only 0.1 % seizure-inducing potential, much lower than other APs [91,92]. The effects of aripiprazole were observed at highest doses characterized by occupancy of >90 % of D2 receptors [90].…”

Section: Aripiprazolementioning

confidence: 99%

Comparative Analysis of the Treatment of Chronic Antipsychotic Drugs on Epileptic Susceptibility in Genetically Epilepsy-prone Rats

et al. 2015

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Antipsychotic drugs (APs) are of great benefit in several psychiatric disorders, but they can be associated with various adverse effects, including seizures. To investigate the effects of chronic antipsychotic treatment on seizure susceptibility in genetically epilepsy-prone rats, some APs were administered for 7 weeks, and seizure susceptibility (audiogenic seizures) was evaluated once a week during treatment and for 5 weeks after drug withdrawal. Furthermore, acute and subchronic (5-day treatment) effects were also measured. Rats received haloperidol (0.2-1.0 mg/kg), clozapine (1-5 mg/kg), risperidone (0.03-0.50 mg/kg), quetiapine (2-10 mg/kg), aripriprazole (0.2-1.0 mg/kg), and olanzapine (0.13-0.66 mg/kg), and tested according to treatment duration. Acute administration of APs had no effect on seizures, whereas, after regular treatment, aripiprazole reduced seizure severity; haloperidol had no effects and all other APs increased seizure severity. In chronically treated rats, clozapine showed the most marked proconvulsant effects, followed by risperidone and olanzapine. Quetiapine and haloperidol had only modest effects, and aripiprazole was anticonvulsant. Finally, the proconvulsant effects lasted at least 2-3 weeks after treatment suspension; for aripiprazole, a proconvulsant rebound effect was observed. Taken together, these results indicate and confirm that APs might have the potential to increase the severity of audiogenic seizures but that aripiprazole may exert anticonvulsant effects. The use of APs in patients, particularly in patients with epilepsy, should be monitored for seizure occurrence, including during the time after cessation of therapy. Further studies will determine whether aripiprazole really has a potential as an anticonvulsant drug and might also be clinically relevant for epileptic patients with psychiatric comorbidities.

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Section: Aripiprazolementioning

confidence: 99%

Comparative Analysis of the Treatment of Chronic Antipsychotic Drugs on Epileptic Susceptibility in Genetically Epilepsy-prone Rats

et al. 2015

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“…Aripiprazole, has only 0.1% seizure-inducing potential (Abilify [package insert], 2004), much lower than other antipsychotics. There are only three reported cases of APZ-associated seizures (Malik and Ravasia, 2005;Tsai, 2006;Li et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity

et al. 2013

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“…This effect can be associated with positive effects on depression, anxiety, and memory [8]. However, it is reported that aripiprazole induced seizures in a 43-year-old man and a 3-year-old child [6,7]. Therefore, in this study, the effect of aripiprazole on seizures was investigated in three different seizure models.…”

Section: Discussionmentioning

confidence: 96%

“…The risk of seizures with aripiprazole is reported to be 0.1%, the lowest among atypical antipsychotic agents [5]. A proconvulsant effect of aripiprazole has been found in at least two human cases [6,7]; in contrast, its anticonvulsant effect is reported in a few experimental animal models [8,9].…”

Section: Introductionmentioning

confidence: 99%

The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide

Shafaroodi

Oveisi

Hosseini

et al. 2015

Epilepsy & Behavior

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Serious generalized tonic–clonic seizures induced by aripiprazole

Cited by 6 publications

References 4 publications

Comparative Analysis of the Treatment of Chronic Antipsychotic Drugs on Epileptic Susceptibility in Genetically Epilepsy-prone Rats

Comparative Analysis of the Treatment of Chronic Antipsychotic Drugs on Epileptic Susceptibility in Genetically Epilepsy-prone Rats

Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity

The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide

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