Serious childhood respiratory infections and asthma in adult life. A population based study

The influence of childhood infections and vaccination on the development of atopy: A systematic review of the direct epidemiological evidence

“…The sibling effect was unexplained by evidence of infection with either hepatitis A or Helicobacter pylori, or by counts of infections or antibiotic prescriptions in early life Linneberg 35 CCTRL 788/647 yexposure to intestinal bacterial pathogens was associated with a higher prevalence of atopy Jones 36 HCHT 402 Associations with a chest infection and a family history of atopic conditions were similarly strong predictors of prevalence of eczema and rhinitis Nuhoglu 37 CS 252 Tuberculin reactivity is not inversely associated with atopy in asthmatic children Sidorchuk 38 CHT 2561 Associations between EBV seropositivity and the occurrence of asthma were not apparent Olesen 39 HCHT 9744 'The incidence of atopic dermatitis increased aftery measles infection, which is surprising in view of the hygiene hypothesis' Bager 40 HCHT 889 The risk of atopy increased significantly with increasing number of childhood infections in the first 2 years of life McKeever 41 CHT 29238 No evidence that exposure to infections reduced the incidence of allergic disease McKeever 42 HCHT 24690 Findings suggest that exposure to antibiotics and to infections in utero is a potentially important risk factor in the development of allergic disease Schauer 43 CCTRL 42/84 Severe respiratory syncytial virus (RSV) bronchiolitis during the first year of life is an important risk factor for the development of recurrent wheezing and sensitisation to common allergens during the subsequent year van der Sande 44 CCTRL 66/122 Severe RSV infection in early life is associated with a higher production of type 2 cytokines in Gambian children at 5 years of age Wenzel 45 CCTRL 13/26 Children were also less atopicyin the respiratory RSV immune globulin group than in the control group Chen 46 CS 8723 The prevalence of infectious diseases was significantly higher in children with allergic disease symptoms Haby 47 CS 974 Factors which increased the risk of recent asthma were: having had a serious respiratory infection in the first 2 years of lifey Suzuki 48 SOC-CCTRL 70-17/26 Infection of Mycobacterium tuberculosis does not systematically upregulate Th1 cells in some patients, and is unlikely to prevent allergic disorders like asthma Larouch 49 CCTRL 42/42 Asthma and AHR were found more frequently in young adults with a past history of bronchiolitis, suggesting that this type of respiratory infection may contribute to altered pulmonary function in adulthood Paunio 50 CS 547910 Measles and atopy occur more frequently together than expected, which does not support the hypothesis that experiencing natural measles infection offers protection against atopic disease Hughes 51 CCTRL 200/200 Association between presentation with respiratory infection during gestation and childhood asthma Ferrari 52 CS 1104 Exposure to SRI is a risk factor for asthma in the past (ie, asthma in childhood and adolescence) Stranneg ( ard...…”

The European Community Respiratory Health Survey: what are the main results so far?

“…ROOST et al [22] reported that having a cat in childhood was negatively associated with cat sensitization in subjects with a family history of atopy, while this association was not found in subjects without such a family history [22]. In local analyses, respiratory infection before the age of 5 yrs was found to be related to current asthma [49], childhood onset of asthma [39], ever having had asthma [28] and past asthma [90]. An association between current asthma and having been hospitalized for a lung disease before the age of 2 yrs, was found in an analysis of an extended screening questionnaire in Bergen in Norway [91].…”

Different slopes for different folks: socioeconomic and racial/ethnic disparities in asthma and hay fever among 173,859 U.S. men and women.

“…Meanwhile, hay fever is commonly considered a disease of affluence, with prevalences positively associated with socioeconomic position in studies of populations in the United Kingdom and other European countries (9)(10)(11)(12)(13)(14). Contributing to the confusing interpretation of these trends in the United States is that while much research has focused on asthma and hay fever in childhood and adolescence, relatively fewer studies have explored racial/ethnic and socioeconomic patterns in asthma and hay fever among adults (15,16).…”