Serine deficiency exacerbates psoriatic skin inflammation by regulating S‐adenosyl methionine‐dependent DNA methylation and NF‐κB signalling activation in keratinocytes
Qinqin Meng,
Ying Liu,
Leiqing Yao
et al.
Abstract:BackgroundSerine metabolism is crucial for tumor oncogenesis and immune responses. S‐adenosyl methionine (SAM), a methyl donor, is typically derived from serine‐driven one‐carbon metabolism. However, the involvement of serine metabolism in psoriatic skin inflammation remains unclear.ObjectivesTo investigate the association between serine metabolism and psoriatic skin inflammation.MethodsClinical samples were collected from patients with psoriasis and the expression of serine biosynthesis enzymes was evaluated.… Show more
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