Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase‐A activity

Cao, Xia; Rui, Lewei; Pennington, Paul R.; Chlan-Fourney, Jennifer; Jiang, Zhichao; Wei, Zhao; Li, Xinmin; Edmondson, Dale E.; Mousseau, Darrell D.

doi:10.1111/j.1471-4159.2009.06300.x

Cited by 39 publications

(32 citation statements)

References 48 publications

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“…Ser209 in human MAO-A also contributes to MAO-A function, but the same does not hold true for the analogous residue in MAO-B (i.e. Ser200) [197]. Other studies have identified specific lysine, tryptophan and tyrosine residues [198] and cysteine residues [199,200] that may contribute either to FAD binding or to stabilizing the protein's conformation, access to the catalytic cleft and its substrate binding capacity [191,198].…”

Section: Molecular Biology Has Identified Amino Acid Residues and Dommentioning

confidence: 99%

Recent Developments in the Regulation of Monoamine Oxidase Form and Function: Is the Current Model Restricting Our Understanding of the Breadth of Contribution of Monoamine Oxidase to Brain [dys]Function?

Mousseau¹,

Baker²

2012

Current Topics in Medicinal Chemistry

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Historically, much of the focus on monoamine oxidases and their substrates has been in the area of depression and the monoamine neurotransmitters serotonin (5-hydroxytryptamine), noradrenaline, and to a lesser extent, dopamine. With both forms of monoamine oxidase (A and B), the production of hydrogen peroxide as a byproduct of the reaction between the monoamine oxidases and their monoamine substrates has also implicated monoamine oxidase-sensitive events in intrinsic cell death pathways, particularly those centered on oxidative stress and peroxyradical-mediated mechanisms. Consequently, and perhaps not unexpectedly, the inhibition of monoamine oxidase has been considered as adjunctive therapy in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, both of which involve a significant oxidative stress component. Yet the literature also provides ambiguities; indeed, not all of the functions of monoamine oxidases are dependent on catalytic activity nor can they all be ascribed to expression levels of the monoamine oxidase protein per se. Recent reports strongly suggest that the functions of monoamine oxidases also rely on posttranslational modifications, epigenetic influences, interactions with other proteins, the cell phenotype and its localization to specific subcellular compartments. These recent developments certainly complicate the issue, yet they need to be duly considered when implicating monoamine oxidases and their inhibitors in both in vitro and in vivo pathological contexts.

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Section: Molecular Biology Has Identified Amino Acid Residues and Dommentioning

confidence: 99%

Recent Developments in the Regulation of Monoamine Oxidase Form and Function: Is the Current Model Restricting Our Understanding of the Breadth of Contribution of Monoamine Oxidase to Brain [dys]Function?

Mousseau¹,

Baker²

2012

Current Topics in Medicinal Chemistry

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“…Animal studies have shown that DHA readily crosses the blood/brain barrier (Ouellet et al, 2009) and plays a critical positive role in all aspects of neuronal growth, synaptic connections, and functioning (Cockburn, 1994; Jamieson et al, 1999; Salem et al, 2001; Chang et al, 2009). This includes roles in regulating the activity of Na + K + ATPase in the neural membrane (Bourre et al, 1989; Turner et al, 2003; Kumosani et al, 2011), neuron size (Ahmad et al, 2002), neurogenesis (Auestad and Innis, 2000; Coti Bertrand et al, 2006; Beltz et al, 2007; Novak et al, 2008; Da Costa et al, 2009; Dagai et al, 2009; He et al, 2009), neurite growth (Calderon and Kim, 2004; Sakamoto et al, 2007; Liu et al, 2008; Novak et al, 2008; Cao et al, 2009), synapse formation and function (Yoshida et al, 1997; Cansev and Wurtman, 2007; Wu et al, 2008; Cao et al, 2009; Wurtman et al, 2009), neuronal integrity and vitality (Issa et al, 2006; Mukherjee et al, 2007; Niemoller et al, 2009), gene expression in the brain (Kitajka et al, 2002), brain glucose transport (Pifferi et al, 2007), cognitive development (Heinemann and Bauer, 2006; Bongiovanni et al, 2007; Coluccia et al, 2009), and learning ability (Bourre et al, 1989; Yoshida et al, 1997; Greiner et al, 1999; Salem et al, 2001; Takeuchi et al, 2002; Shirai and Suzuki, 2004; Garcia-Calatayud et al, 2005; Lim et al, 2005; Chung et al, 2008; Holguin et al, 2008; Fedorova et al, 2009; He et al, 2009; Hooijmans et al, 2009; Jiang et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Sex Differences in the Relationship of Dietary Fatty Acids to Cognitive Measures in American Children

Lassek¹,

Gaulin²

2011

Front. Evol. Neurosci.

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Because the first neurons evolved in an environment high in the n−3 (omega-3) fatty acid docosahexaenoic acid (DHA), this fatty acid became a major component of neural structure and function and makes up 10% of the dry weight of the human brain. Since n−3 fatty acids must come from the diet, this suggests a possible positive role for dietary n−3 fatty acids in cognition and a possible negative role for n−6 fatty acids, which compete with n−3 for access to critical enzymes. Because human females must provide DHA for the growth of the unusually large brains of their offspring from maternal fat stored during childhood, their need for DHA is especially great. We used stepwise regression to determine whether particular dietary fatty acids and other nutrients were related to cognitive performance in over 4000 American children aged 6–16 from the Third National Health and Nutrition Examination Survey; a variety of possible biological, social, and environmental risk factors were statistically controlled. In this context the only dietary factors related to cognitive performance were n−3 and n−6 fatty acids. Dietary n−3 fatty acids were positively related to cognitive test scores in male and female children, while n−6 showed the reverse relationship, significantly so in females. In female children the positive effects of n−3 intake were twice as strong as in males and exceeded the negative effects of lead exposure. This suggests that increasing dietary intake of n−3 and decreasing n−6 fatty acids may have cognitive benefits in children, especially in females.

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“…Cytokines could regulate the synthesis of dopamine in the basal ganglia [36] and METH treatment also showed increases of TNF α and IL-6 expressions in the frontal cortex [37]. Inflammatory effects have also been reported to increase the expression and activity of MAO-A in the neural cells [38, 39]. Based on these findings, EA influences MAO-A expression maybe via regulating the inflammatory cytokines-related pathways.…”

Section: Discussionmentioning

confidence: 99%

Effects of Electroacupuncture on Methamphetamine‐Induced Behavioral Changes in Mice

Lee

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Methamphetamine (METH) is a major drug of abuse worldwide, and no efficient therapeutic strategies for treating METH addiction are currently available. Continuous METH use can cause behavioral upregulation or psychosis. The dopaminergic pathways, particularly the neural circuitry from the ventral tegmental area to the nucleus accumbens (NAc), have a critical role in this behavioral stage. Acupuncture has been used for treating diseases in China for more than 2000 years. According to a World Health Organization report, acupuncture can be used to treat several functional disorders, including substance abuse. In addition, acupuncture is effective against opioids addiction. In this study, we used electroacupuncture (EA) for treating METH-induced behavioral changes and investigated the possible therapeutic mechanism. Results showed that EA at the unilateral Zhubin (KI9)–Taichong (LR3) significantly reduced METH-induced behavioral sensitization and conditioned place preference. In addition, both dopamine and tyrosine hydroxylase (TH) levels decreased but monoamine oxidase A (MAO-A) levels increased in the NAc of the METH-treated mice receiving EA compared with those not receiving EA. EA may be a useful nonpharmacological approach for treating METH-induced behavioral changes, probably because it reduces the METH-induced TH expression and dopamine levels and raises MAO-A expression in the NAc.

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Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase‐A activity

Cited by 39 publications

References 48 publications

Recent Developments in the Regulation of Monoamine Oxidase Form and Function: Is the Current Model Restricting Our Understanding of the Breadth of Contribution of Monoamine Oxidase to Brain [dys]Function?

Recent Developments in the Regulation of Monoamine Oxidase Form and Function: Is the Current Model Restricting Our Understanding of the Breadth of Contribution of Monoamine Oxidase to Brain [dys]Function?

Sex Differences in the Relationship of Dietary Fatty Acids to Cognitive Measures in American Children

Effects of Electroacupuncture on Methamphetamine‐Induced Behavioral Changes in Mice

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