Series dual-electrode detector for liquid chromatography/electrochemistry

Roston, Daryl A.; Kissinger, Peter T.

doi:10.1021/ac00240a019

Cited by 114 publications

(58 citation statements)

References 12 publications

(12 reference statements)

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“…The limits of detection for these compounds were estimated to be 4.68 mM (7.72 fmol) for ferulic acid, 2.73 mM (4.50 fmol) for protocatechuic acid, and 1.17 mM (1.93 fmol) for gentisic acid. These values are similar to those obtained for phenolic compounds using a dual electrode CE-EC system based on a ring-disk electrode con®g-uration [11], but much higher than those obtained by LC-EC with dual electrode detection [4,17]. This can be attributed in part to the higher loading capacity of the LC versus CE.…”

Section: Detection Of Phenolssupporting

confidence: 83%

“…These compounds are oxidized to quinones that are stable in the time frame of the detection. The collection ef®ciency values are very similar to those obtained using a conventional thin-layer cell in LC-EC [17]. A lower collection ef®ciency (0.18) was obtained for ferulic acid and was also in agreement with the LC-EC results.…”

Section: Detection Of Phenolssupporting

confidence: 82%

“…Most importantly, if everything else is constant, it is dependent upon the stability (reversibility) of the redox couple. Values for the collection ef®ciency of phenolic compounds using equivalent planar electrodes employed in LC-EC systems have been reported [4,17].…”

Section: Detection Of Phenolsmentioning

confidence: 99%

“…A lower collection ef®ciency (0.18) was obtained for ferulic acid and was also in agreement with the LC-EC results. Ferulic acid undergoes an ECE mechanism of oxidation that decreases the amount of quinone detected at the second electrode [17].…”

Section: Detection Of Phenolsmentioning

confidence: 99%

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Characterization of an Integrated On-Capillary Dual Electrode for Capillary Electrophoresis-Electrochemistry

Holland

Harmony

Lunte³

1999

Electroanalysis

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An integrated on-capillary dual electrode electrochemical detector for capillary electrophoresis consisting of two platinum wires is described. The electrodes are permanently ®xed so that no alignment is necessary. The detector was evaluated for direct amperometric detection in the series con®guration. Collection ef®ciencies were calculated for a series of phenolic acids exhibiting different degrees of chemical reversibility. The linearity and limits of detection at both electrodes were determined. The selectivity of the system was demonstrated by the detection of ferulic acid in beer.

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Section: Detection Of Phenolssupporting

confidence: 83%

Section: Detection Of Phenolssupporting

confidence: 82%

Section: Detection Of Phenolsmentioning

confidence: 99%

Section: Detection Of Phenolsmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of an Integrated On-Capillary Dual Electrode for Capillary Electrophoresis-Electrochemistry

Holland

Harmony

Lunte³

1999

Electroanalysis

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“…While using a single electrode with microchip electrophoresis enables detection of separated analytes [15][16][17][18][19], it has been previously shown with conventional CE and LC that the use of serially configured dual electrodes offers increased selectivity, which can be useful for analyzing complex mixtures [20,21]. Electroactive species that undergo reversible redox reactions will be detected at both electrodes, whereas electroactive species that do not have reversible redox couples can only be detected at one of the two electrodes.…”

Section: Introductionmentioning

confidence: 99%

Use of micromolded carbon dual electrodes with a palladium decoupler for amperometric detection in microchip electrophoresis

Mecker

Martin

2006

Electrophoresis

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The fabrication and evaluation of micromolded dual carbon ink electrodes and their integration with a fabricated palladium decoupler for use in microchip electrophoresis is described. As opposed to previous work involving carbon-based dual electrodes with microchip electrophoresis, this approach results in electrodes that are amenable to mass production in a manner where the decoupler/electrode alignment is fixed and reproducible. In this work, electrode sizes and spacings were optimized to result in dual carbon electrodes that are 1 microm in height and separated by 100 microm. Fluorescence microscopy was used to investigate leakage around the electrode/channel interface as well as to investigate what effect the dual electrodes have on band broadening phenomena. The performance of the microelectrodes was demonstrated by the separation and selective dual electrode detection of neurotransmitters in the presence of ascorbic acid. It was also found that addition of SDS to the buffer system improved both the LODs and collection efficiencies. This approach, which is the first involving carbon-based dual electrodes with an on-chip palladium decoupler, will be useful for separating and detecting neurotransmitters that are either collected by in vivo sampling or released from cells on-chip.

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Biomedical Uses of High‐Performance Liquid Chromatography with Electrochemical Detection

Mefford¹

1985

Methods of Biochemical Analysis

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Series dual-electrode detector for liquid chromatography/electrochemistry

Cited by 114 publications

References 12 publications

Characterization of an Integrated On-Capillary Dual Electrode for Capillary Electrophoresis-Electrochemistry

Characterization of an Integrated On-Capillary Dual Electrode for Capillary Electrophoresis-Electrochemistry

Use of micromolded carbon dual electrodes with a palladium decoupler for amperometric detection in microchip electrophoresis

Biomedical Uses of High‐Performance Liquid Chromatography with Electrochemical Detection

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