Sericin mediated gold/silver bimetallic nanoparticles and exploration of its multi-therapeutic efficiency and photocatalytic degradation potential

Das, Gitishree; Seo, Su-Jin; Yang, In-Jun; Nguyen, Ly; Shin, Han‐Seung; Patra, Jayanta Kumar

doi:10.1016/j.envres.2023.115935

Cited by 11 publications

(7 citation statements)

References 88 publications

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“…Recent studies have revealed that bimetallic nanoparticles that combine the properties of two metals in a single nanostructured system exhibit promising applications [ 105 ]. For example, ZnONPs are well-dispersed and can effectively prevent the aggregation of AgNPs, and AgNPs/ZnONPs hybrids have a synergistic antimicrobial effect that can inhibit bacterial growth or kill bacteria [ 106 , 107 ].…”

Section: Preparation and Antimicrobial Properties Of Ss Antimicrobial...mentioning

confidence: 99%

“…For example, ZnONPs are well-dispersed and can effectively prevent the aggregation of AgNPs, and AgNPs/ZnONPs hybrids have a synergistic antimicrobial effect that can inhibit bacterial growth or kill bacteria [ 106 , 107 ]. Das et al [ 105 ] used SS as a reducing agent to synthesize bimetallic gold-silver nanoparticles (Au/AgNPs), called BM-GS NPs. In addition to being a reducing agent, SS can also be used as a capping agent and stabilizer for bimetallic gold-silver nanoparticles.…”

Section: Preparation and Antimicrobial Properties Of Ss Antimicrobial...mentioning

confidence: 99%

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Silk Sericin and Its Composite Materials with Antibacterial Properties to Enhance Wound Healing: A Review

Wang,

Zhuo,

Fang

et al. 2024

Biomolecules

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Wound infections may disrupt the normal wound-healing process. Large amounts of antibiotics are frequently used to prevent pathogenic infections; however, this can lead to resistance development. Biomaterials possessing antimicrobial properties have promising applications for reducing antibiotic usage and promoting wound healing. Silk sericin (SS) has been increasingly explored for skin wound healing applications owing to its excellent biocompatibility and antioxidant, antimicrobial, and ultraviolet-resistant properties. In recent years, SS-based composite biomaterials with a broader antimicrobial spectrum have been extensively investigated and demonstrated favorable efficacy in promoting wound healing. This review summarizes various antimicrobial agents, including metal nanoparticles, natural extracts, and antibiotics, that have been incorporated into SS composites for wound healing and elucidates their mechanisms of action. It has been revealed that SS-based biomaterials can achieve sustained antimicrobial activity by slow-release-loaded antimicrobial agents. The antimicrobial-loaded SS composites may promote wound healing through anti-infection, anti-inflammation, hemostasis, angiogenesis, and collagen deposition. The manufacturing methods, benefits, and limitations of antimicrobial-loaded SS materials are briefly discussed. This review aims to enhance the understanding of new advances and directions in SS-based antimicrobial composites and guide future biomedical research.

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Section: Preparation and Antimicrobial Properties Of Ss Antimicrobial...mentioning

confidence: 99%

Section: Preparation and Antimicrobial Properties Of Ss Antimicrobial...mentioning

confidence: 99%

Silk Sericin and Its Composite Materials with Antibacterial Properties to Enhance Wound Healing: A Review

Wang,

Zhuo,

Fang

et al. 2024

Biomolecules

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“…For the standard (control), the progress of the pathogen growth constantly rose with the time of incubation. It could be inferred that the SGNPs, because of their nanoscale size, could have easily invaded the cells of the bacteria, causing widespread destruction of the membrane wall, and eventually ending in cellular demise [50,51].…”

Section: Assessment Of Antibacterial Mechanism Of Actionmentioning

confidence: 99%

“…Melanin is a factor in skin coloration, and is produced by the melanogenesis pathway in the melanocyte cells situated in the lower epidermis [68]. Melanin is formed by L-tyrosine oxidation, followed by transformation to L-dihydroxyphenylalanine [50,69]. Despite its defensive functions, such as protecting the skin from the adverse effect of harmful ultraviolet rays, its surplus formation resulted in the production of age spots, freckles, hyperpigmentation, and melisma [70][71][72][73].…”

Section: Assessment Of Tyrosinase Inhibition Effect Of Sgnpsmentioning

confidence: 99%

“…The antibacterial mode of action of SGNPs on the tested Gram-positive and Gramnegative microbes was determined following the time-kill assay, as discussed in our previous study [50]. For the antibacterial mode of action studies, only two pathogens, E. coli and E. feacium, were selected from among the six tested pathogens due to the better inhibition activity of the SGNPs.…”

Section: Cell Viability Effectmentioning

confidence: 99%

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Evaluation of Antibacterial Mechanism of Action, Tyrosinase Inhibition, and Photocatalytic Degradation Potential of Sericin-Based Gold Nanoparticles

Das

Patra

2023

IJMS

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In recent times, numerous natural materials have been used for the fabrication of gold nanoparticles (AuNPs). Natural resources used for the synthesis of AuNPs are more environment friendly than chemical resources. Sericin is a silk protein that is discarded during the degumming process for obtaining silk. The current research used sericin silk protein waste materials as the reducing agent for the manufacture of gold nanoparticles (SGNPs) by a one-pot green synthesis method. Further, the antibacterial effect and antibacterial mechanism of action, tyrosinase inhibition, and photocatalytic degradation potential of these SGNPs were evaluated. The SGNPs displayed positive antibacterial activity (8.45–9.58 mm zone of inhibition at 50 μg/disc) against all six tested foodborne pathogenic bacteria, namely, Enterococcus feacium DB01, Staphylococcus aureus ATCC 13565, Listeria monocytogenes ATCC 33090, Escherichia coli O157:H7 ATCC 23514, Aeromonas hydrophila ATCC 7966, and Pseudomonas aeruginosa ATCC 27583. The SGNPs also exhibited promising tyrosinase inhibition potential, with 32.83% inhibition at 100 μg/mL concentration as compared to 52.4% by Kojic acid, taken as a reference standard compound. The SGNPs also displayed significant photocatalytic degradation effects, with 44.87% methylene blue dye degradation after 5 h of incubation. Moreover, the antibacterial mode of action of the SGNPs was also investigated against E. coli and E. feacium, and the results show that due to the small size of the nanomaterials, they could have adhered to the surface of the bacterial pathogens, and could have released more ions and dispersed in the bacterial cell wall surrounding environment, thereby disrupting the cell membrane and ROS production, and subsequently penetrating the bacterial cells, resulting in lysis or damage to the cell by the process of structural damage to the membrane, oxidative stress, and damage to the DNA and bacterial proteins. The overall outcome of the current investigation concludes the positive effects of the obtained SGNPs and their prospective applications as a natural antibacterial agent in cosmetics, environmental, and foodstuff industries, and for the management of environmental contagion.

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Silk Sericin Protein: Turning Discarded Biopolymer into Ecofriendly and Valuable Reducing, Capping, and Stabilizing Agent for Nanoparticles Synthesis Using Sonication

Summer

Ali

Tahir

et al. 2023

Macro Chemistry & Physics

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This current study is designed to incorporate sericin protein as a reducing, capping, and stabilizing agent to synthesize sonication‐mediated silver nanoparticles. Fabrication of sericin‐reduced silver nanoparticles (Sr‐AgNPs) is confirmed using UV–visible spectrophotometry, zeta sizer, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X‐Ray diffraction (XRD), and thermogravimetric analysis (TGA). UV–Vis spectral peak of Sr‐AgNPs is observed at 420–440nm while the average size is found between 3 to 30 nm. SEM also confirms the reduction of large‐sized (1–40 µm) sericin macromolecules into nanometric hexagonal and triangular silver nanoparticles with a normal distribution (polydispersity index > 0.5). FTIR peaks from 500 to 4000cm−1 are analyzed for sericin while Sr‐AgNPs peaks with minor shifts (700–1000 cm−1 (COOCO stretching) in Sr‐AgNPs) are also observed. XRD peaks of 2θ at 27° with multiple low peaks at 38.2°, 47°, 49°, and 63.8° authenticate the amorphous nature of sericin and sharp peaks at 36°, 48°, 54.3°, and 61.9° with miller indices (hkl) of 98, 111, 200, and 211, assess the crystalline structure of Sr‐AgNPs. TGA reveals that sericin enhances the stability of silver NPs at high temperature (200–600 °C) by lowering the percentage weight loss from 70–80% to 60–65%.

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Sericin mediated gold/silver bimetallic nanoparticles and exploration of its multi-therapeutic efficiency and photocatalytic degradation potential

Cited by 11 publications

References 88 publications

Silk Sericin and Its Composite Materials with Antibacterial Properties to Enhance Wound Healing: A Review

Silk Sericin and Its Composite Materials with Antibacterial Properties to Enhance Wound Healing: A Review

Evaluation of Antibacterial Mechanism of Action, Tyrosinase Inhibition, and Photocatalytic Degradation Potential of Sericin-Based Gold Nanoparticles

Silk Sericin Protein: Turning Discarded Biopolymer into Ecofriendly and Valuable Reducing, Capping, and Stabilizing Agent for Nanoparticles Synthesis Using Sonication

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