Serial thallium-201 imaging after dipyridamole for coronary disease detection: Quantitative analysis using myocardial clearance

Okada, Robert D.; Dai, Yu-Hua; Boucher, Charles A.; Pohost, Gerald M.

doi:10.1016/0002-8703(84)90088-7

Cited by 32 publications

(2 citation statements)

References 13 publications

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“…This method has been demonstrated to be useful, especially in patients who cannot undergo 201 myocardial washout after dipyridamole infusion can distinguish between coronary stenoses of graded severity [9][10][11], and it improves accuracy in the detection of CAD [12]. But the effect of aminophylline on thallium-201 washout rate after dipyridamole is unknown.…”

Section: Introductionmentioning

confidence: 99%

Intravenous Aminophylline Affects Myocardial Washout of Thallium-201 after Dipyridamole Infusion

Takeishi¹,

Tonooka²,

Ikeda³

et al. 1992

Am J Noninvas Cardiol

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Thallium-201 myocardial perfusion imaging with dipyridamole was performed on 85 patients with suspected coronary artery disease (CAD). Twentyeight patients had normal coronary arteries (control group) and 57 patients had 50% or greater stenosis in one or more of the major coronary arteries (CAD group). In the control group, aminophylline was infused intravenously in 12 patients during dipyridamole testing. The mean washout rate (WR) of these 12 patients was faster than that of the 16 patients without aminophylline (42 vs. 34%, p < 0.01). Then, normal limits of WR were defined separately from the patients in the control group with and without aminophylline. The diagnostic accuracy in the detection of individual diseased coronary arteries by WR analysis, for which normal limits of WR were determined from all patients in the control group, was 64% (110/171). When the normal limits were calculated separately with and without aminophylline, the diagnostic accuracy increased to 76% (130/171, p < 0 .05). Aminophylline affected the myocardial washout of thallium-201 after dipyridamole infusion. Specific sets of normal limits obtained with and without aminophylline are required for the accurate evaluation of WR in CAD patients.

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Section: Introductionmentioning

confidence: 99%

Intravenous Aminophylline Affects Myocardial Washout of Thallium-201 after Dipyridamole Infusion

Takeishi¹,

Tonooka²,

Ikeda³

et al. 1992

Am J Noninvas Cardiol

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“…χορήγηση διπυριδαµόλης αµέσως και 2,5 -4 ώρες µετά, ανιχνεύει τη φυσιολογική ή µη κινητικότητα των τµηµάτων αυτών στην κοιλιογραφία, µε προγνωστική αξία συγκρίσιµη µε αυτήν της κλασσικής δοκιµασίας κόπωσης. Ανάλογα αποτελέσµατα δηµοσίευσαν οι Okada και συνεργάτες (Okada, Dai et al, 1984).…”

Section: ενδείξεις αντενδείξεις ευαισθησία ειδικότητα διαγνωστική αξίαunclassified

Διαγνωστική Διερεύνηση Της Νόσου Των Μικρών Στεφανιαίων Αρτηριών Με Αναίμακτες Τεχνικές

Κουνατιάδης¹

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Pharmacologic Stress Imaging

Beller

1991

JAMA

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Pharmacologic stress imaging has increasingly been employed as an alternative to exercise imaging for detection of coronary artery disease and risk stratification particularly in patients who are unable to perform adequate exercise. Sensitivity and specificity of thallium 201 scintigraphy using intravenous dipyridamole infusion as a stress for coronary artery disease detection average 85% and 91%, respectively. Dipyridamole imaging is also useful for differentiating between ischemia and scar and identifying patients who have an increased risk for subsequent cardiac events. Dipyridamole imaging is particularly useful for preoperative risk stratification in patients undergoing surgery for peripheral vascular or aortic disease. Dipyridamole imaging is also useful for identifying residual myocardial ischemia after myocardial infarction and detecting restenosis after coronary angioplasty. Adverse side effects of dipyridamole are promptly reversed by aminophylline. Dipyridamole stress can also be employed in association with echocardiography for detection of ischemia-induced regional wall motion abnormalities.

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Serial thallium-201 imaging after dipyridamole for coronary disease detection: Quantitative analysis using myocardial clearance

Cited by 32 publications

References 13 publications

Intravenous Aminophylline Affects Myocardial Washout of Thallium-201 after Dipyridamole Infusion

Intravenous Aminophylline Affects Myocardial Washout of Thallium-201 after Dipyridamole Infusion

Διαγνωστική Διερεύνηση Της Νόσου Των Μικρών Στεφανιαίων Αρτηριών Με Αναίμακτες Τεχνικές

Pharmacologic Stress Imaging

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