Serial TAPSE at 1 Year, Not Baseline TAPSE, Predicts Survival Differences in Patients With an Incident Diagnosis of Pulmonary Arterial Hypertension

Fields, Anjali V.; Roberts, Justin; Forfia, Paul R.

doi:10.1378/chest.1116846

Cited by 2 publications

(1 citation statement)

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“…Parameters that are easy to obtain and highly reproducible, such as tricuspid annular plane systolic excursion (TAPSE) and maximal annulus tricuspid systolic velocity (S'), can be used to evaluate RV function (Visser et al 2014, 2015, Chetboul et al 2016. A low TAPSE value has been associated with poor prognosis in human patients with right heart failure secondary to PH (Fields et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Echocardiographic features of pre- and postcapillary pulmonary hypertension with a focus on the right ventricle in dogs

et al. 2021

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Pulmonary hypertension (PH) in dogs is a syndrome that can occur secondary to several causes, including left heart disease (postcapillary) and chronic respiratory disease (precapillary). This study evaluates morphological and functional consequences in the right ventricle (RV) of dogs with pre- and postcapillary PH through echocardiography, and also considers the severity of PH (mild, moderate or severe). Echocardiography was performed on 66 dogs of various breeds and weights (age >3 years old) which were assigned to three groups: postcapillary PH, which included mitral valve disease/endocardiosis, precapillary PH, which included chronic respiratory diseases (bronchitis, collapse of the trachea and primary lung cancer or metastasis), and finally, a healthy group of controls. The parameters for RV morphology were RV1, RV2, and RV3 for systole and diastole. The following measurements were used to assess RV systolic function: tricuspid annular plane systolic excursion (TAPSE), TAPSE:Ao (aorta), maximum velocity of the tricuspid systolic wave obtained by tissue Doppler (S’), S’:Ao, right ventricle end-diastolic area (RVEDA); RVEDA:BSA (body surface area); flow velocity integral (FVI) and FVI:Ao. The variables were assessed using ANOVA. The results showed that RV3d, RV1s, S’:Ao, S’, and FVI were able to distinguish cases of pre- and postcapillary PH in this study. Remodeling of the RV of dogs with PH was observed, which can be influenced by the pre- or postcapillary origin of the PH, with dilation in dogs with postcapillary PH and severe PH. The results for RV systolic function were similar, with FVI and FVI:Ao showing that RV ejection function is reduced in dogs with postcapillary PH and with severe PH.

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Section: Introductionmentioning

confidence: 99%