Serial studies of glomerular filtration rate and renal plasma flow in renal transplant donors, identical twins and allograft recipients

Flanigan, William J.; Burns, Robert O.; Takacs, Frank J.; Jp, Merrill

doi:10.1097/00007890-196908000-00019

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1985

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“…After uninephrectomy in healthy individuals, the glo merular filtration rate (GFR) amounts to roughly 70% of the original value [1,2], The increase in GFR in the remaining kidney is a result of vasodilation in the spared organ [1,3]. One can wonder whether in renal diseases with affected and/or hyalinized glomeruli such an adapta tion is present before GFR falls.…”

Section: Introductionmentioning

confidence: 99%

Effect of Low-Dose Dopamine on Effective Renal Plasma Flow and Glomerular Filtration Rate in 32 Patients with IgA Glomerulopathy

Beukhof¹,

Terwee²,

Sluiter³

et al. 1985

Am J Nephrol

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Low doses of dopamine are known to increase renal blood flow without influencing heart rate or systemic blood pressure. Indeed this effect was observed in 32 patients with IgA glomerulopathy. A concomitant increase in glomerular filtration rate (GFR), however, was only observed in patients with a baseline GFR ≥ 73 ml/min/1.73 m². Moreover, the change in GFR during dopamine infusion increased with increasing baseline GFR. We conclude that in IgA glomerulopathy nephron loss is compensated for by a progressive utilization of the kidney’s functional reserve capacity which seems exhausted when compensated GFR falls below 73 ml/min/1.73 m².

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Section: Introductionmentioning

confidence: 99%