Serial serum C-reactive protein to monitor recovery from acute hematogenous osteomyelitis in children

Roine, Irmeli; Faingezicht, Idis; Arguedas, Adriano; Herrera, José F.; Rodrı́guez, Francisco

doi:10.1097/00006454-199501000-00008

Cited by 100 publications

(59 citation statements)

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“…It has been reported that CRP was increased in hematogenous osteomyelitis in children, and decreased faster than ESR after appropriate treatment, reflecting the effectiveness of therapy with a higher sensitivity than ESR. 26 It is also known that patients with peripheral artery disease have increased levels of inflammation markers. 27 Elevated levels of CRP have been associated with poor long-term prognosis in patients with peripheral artery disease.…”

Section: Discussionmentioning

confidence: 99%

Predictors of amputation in diabetics with foot ulcer: Single center experience in a large Turkish cohort

Yeşil¹,

Akıncı²,

Yener³

et al. 2009

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OBJECTIVE: Prediction of diabetic foot ulcer outcome may be helpful for clinicians in optimizing and individualizing management strategy. The aim of the present study was to examine the possibility of predicting the outcome of patients with diabetic foot ulcers by using easily assessed clinical and laboratory parameters at baseline. DESIGN: In this observational study, data were collected prospectively in 670 consecutive diabetic foot ulcer episodes in 510 patients examined between January 1999 and June 2008 and were used to evaluate potential predictors of amputation retrospectively. After exclusion of patients who did not come to the hospital for follow-up for a minimum of six months, data of 574 foot ulcer episodes were evaluated. RESULTS: Limb ischemia, osteomyelitis and presence of gangrene and ulcer depth, determined by the Wagner classification system, were the major independent predictors of overall and major amputations. Older age, presence of coronary artery disease, smoking and ulcer size were found to be associated with either overall or major amputations. Baseline levels of acute phase reactants (white blood cell count, polymorphonuclear leukocyte count, platelet count, erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP) and albumin) and decreased hemoglobin levels were associated with amputation risk. Multivariate analysis showed that one standard deviation increase in baseline CRP and ESR levels were independent predictors of overall and major amputations, respectively. CONCLUSIONS: The presence of limb ischemia, osteomyelitis, local and diffuse gangrene and ulcer depth were independent predictors of amputation. Baseline levels of ESR and CRP appeared to be helpful for clinicians in predicting amputation.

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Section: Discussionmentioning

confidence: 99%

Predictors of amputation in diabetics with foot ulcer: Single center experience in a large Turkish cohort

Yeşil¹,

Akıncı²,

Yener³

et al. 2009

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“…CRP peaks to high values (often >100 mg/L) in 2-3 days, but then normalises within 11 days if the recovery is uneventfully [36]. If CRP levels continue to rise, or remain high on the 4th day of treatment, a complication should be suspected [77].…”

Section: Follow-upmentioning

confidence: 99%

“…Plain radiographs are sufficient for the detection of potential sequelae, whilst MRI is reserved for special cases [45]. CRP, or M a n u s c r i p t 17 if not available ESR, is also checked because increasing values may hint towards sequelae [3,36,74,75,77].…”

Section: Follow-upmentioning

confidence: 99%

Antibiotic treatment for acute haematogenous osteomyelitis of childhood: Moving towards shorter courses and oral administration

Pääkkönen¹,

Peltola²

2011

International Journal of Antimicrobial Agents

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“…Serial CRP measurements are also used to monitor the evolution of bacterial diseases because CRP concentration drops quickly in response to effective treatment (9). Monitoring CRP concentration can lead to shorter antibiotic regimens or, alternatively, can alert one to the likelihood of complications and help predict outcome, even earlier than clinical signs (10). Conventional laboratory methods for CRP can be unavailable in urgent situations, or may not provide results in a timely manner.…”

Section: Introductionmentioning

confidence: 99%

Reliability of two different bedside assays for C-reactive protein in newborn infants

Zecca

Barone

Corsello

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: Bedside tests for C-reactive protein (CRP) have been studied in pediatric patients, but not in neonates. Methods:This study compared the results of two rapid bedside tests for CRP (Quick-Read CRP, Orion Diagnostic, Espoo, Finland and NycoCard CRP-Single Test, Axis-Shield, Oslo, Norway) with those of our central laboratory method (CRP-Lab) in newborn infants. CRP concentrations were determined using 72 samples obtained from 43 infants with suspected sepsis occurring between 1 and 28 days of life. Results: Considering positive CRP concentrations to be G10 mg/L, both bedside tests had good specificity (Quick-Read 80.5%, NycoCard 83.3%) and sensitivity (Quick-Read 97.2%, NycoCard 94.4%) when compared with our CRP-Lab. The agreement of measurement with central laboratory values was high for both the bedside tests, without statistically significant differences between the methods. The Quick-Read and NycoCard methods did not show any statistically significant systematic proportional bias when compared with the central laboratory values. The accuracy of the results of both bedside tests is somewhat decreased when CRP concentrations are )100 mg/L. Conclusions: This study shows that both the QuickRead and the NycoCard test can be used for serial determinations of CRP concentrations in newborn infants. They require small volumes of blood and provide reliable results in -5 min.

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Serial serum C-reactive protein to monitor recovery from acute hematogenous osteomyelitis in children

Cited by 100 publications

References 0 publications

Predictors of amputation in diabetics with foot ulcer: Single center experience in a large Turkish cohort

Predictors of amputation in diabetics with foot ulcer: Single center experience in a large Turkish cohort

Antibiotic treatment for acute haematogenous osteomyelitis of childhood: Moving towards shorter courses and oral administration

Reliability of two different bedside assays for C-reactive protein in newborn infants

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