Serial quantitative diffusion tensor MRI of the premature brain: Development in newborns with and without injury

Miller, Steven P.; Vigneron, Daniel B.; Henry, Roland G.; Bohland, Mary Ann; Ceppi-Cozzio, Camilla; Hoffman, Chen; Newton, Nancy; Partridge, John Colin; Ferriero, Donna M.; Barkovich, A. James

doi:10.1002/jmri.10205

Cited by 295 publications

(226 citation statements)

References 16 publications

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“…63 Initial findings show promising results for the analysis of white matter maturation. Evidence has been found recently for underlying delay in white matter maturation in preterm infants with brain injury, 64,65 as well as in AGA preterm infants without brain injury. 26 …”

Section: Effects Of Premature Birth On Total and Regional White Mattementioning

confidence: 99%

Regional Brain Development in Serial Magnetic Resonance Imaging of Low-Risk Preterm Infants

Mewes

Hüppi²,

Als³

et al. 2006

Pediatrics

143

105

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OBJECTIVE. MRI studies have shown that preterm infants with brain injury have altered brain tissue volumes. Investigation of preterm infants without brain injury offers the opportunity to define the influence of early birth on brain development and provide normative data to assess effects of adverse conditions on the preterm brain. In this study, we investigated serial MRI of low-risk preterm infants with the aim to identify regions of altered brain development.METHODS. Twenty-three preterm infants appropriate for gestational age without magnetic resonance-visible brain injury underwent MRI twice at 32 and at 42 weeks' postmenstrual age. Fifteen term infants were scanned 2 weeks after birth. Brain tissue classification and parcellation were conducted to allow comparison of regional brain tissue volumes. Longitudinal brain growth was assessed from preterm infants' serial scans.RESULTS. At 42 weeks' postmenstrual age, gray matter volumes were not different between preterm and term infants. Myelinated white matter was decreased, as were unmyelinated white matter volumes in the region including the central gyri. The gray matter proportion of the brain parenchyma constituted 30% and 37% at 32 and 42 weeks' postmenstrual age, respectively.CONCLUSIONS. This MRI study of preterm infants appropriate for gestational age and without brain injury establishes the influence of early birth on brain development. No decreased cortical gray matter volumes were found, which is in contrast to findings in preterm infants with brain injury. Moderately decreased white matter volumes suggest an adverse influence of early birth on white matter development. We identified a sharp increase in cortical gray matter volume in preterm infants' serial data, which may correspond to a critical period for cortical development.www.pediatrics.org/cgi

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Section: Effects Of Premature Birth On Total and Regional White Mattementioning

confidence: 99%

Regional Brain Development in Serial Magnetic Resonance Imaging of Low-Risk Preterm Infants

Mewes

Hüppi²,

Als³

et al. 2006

Pediatrics

143

105

View full text Add to dashboard Cite

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“…Putative perinatal and post-natal risk factors include early illness severity as measured by the Score of Neonatal Acute Physiology-Version II (SNAP-II) [14,15], infection [9,16,17], necrotizing enterocolitis [16,17], patent ductus arteriosus [18], chronic lung disease [18][19][20][21], and neonatal procedural pain [22]. We hypothesized that these ante-, peri-and postnatal comorbidities, rather than gestational age at birth, would predict poorer microstructural development in the corticospinal tract, as evidenced by higher mean diffusivity and lower fractional anisotropy in this motor pathway [23,24].…”

Section: Introductionmentioning

confidence: 99%

Score for Neonatal Acute Physiology–II and Neonatal Pain Predict Corticospinal Tract Development in Premature Newborns

Zwicker¹,

Grunau²,

Adams³

et al. 2013

Pediatric Neurology

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114

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Premature infants are at risk for adverse motor outcomes, including cerebral palsy and developmental coordination disorder. The purpose of this study was to examine the relationship of ante-, peri-, and postnatal risk factors for abnormal development of the corticospinal tract, the major voluntary motor pathway, during the neonatal period. In a prospective cohort study, 126 premature neonates (24-32 weeks gestational age) underwent serial brain imaging near birth and at term-equivalent age. Using diffusion tensor tractography, mean diffusivity and fractional anisotropy of the corticospinal tract were measured to reflect microstructural development. Generalized estimating equation models examined associations of risk factors on corticospinal tract development.The perinatal risk factor of greater early illness severity [as measured by the Score for Neonatal Acute Physiology-II (SNAP-II)] was associated with a slower rise in fractional anisotropy of the corticospinal tract (p=0.02), even after correcting for gestational age at birth and postnatal risk factors (p=0.009). Consistent with previous findings, neonatal pain adjusted for morphine and postnatal infection were also associated with a slower rise in fractional anisotropy of the corticospinal tract (p=0.03 and 0.02 respectively). Lessening illness severity in the first hours of life might offer potential to improve motor pathway development in premature newborns.

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“…MR studies in recent years have linked premature birth to white matter (WM) abnormalities or myelination delays (Maalouf et al, 1999;Miller et al, 2002;Arzoumanian et al, 2003), and to abnormalities of gray matter development (Inder et al, 2005). These effects have sometimes been observed as early as term-equivalent age.…”

Section: Introductionmentioning

confidence: 99%

Accelerated cerebral white matter development in preterm infants: A voxel-based morphometry study with diffusion tensor MR imaging

et al. 2008

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Twenty-seven preterm infants were compared to 10 full-term infants at term equivalent age using a voxel-based analysis of diffusion tensor imaging of the brain. Preterm infants exhibited higher fractional anisotropy values, which may suggest accelerated maturation, in the location of the sagittal stratum. While some earlier findings in preterm infants have suggested developmental delays, the results of this study are more consistent with accelerated white matter development, possibly as a result of increased sensorimotor stimulation in the extrauterine environment. These results are the first to suggest that the increased intensity of stimulation associated with preterm birth may advance the process of white matter maturation in the human brain. Questions remain about whether these findings reflect acceleration of the process of white matter maturation generally, or localized alterations induced specifically by activity in affected pathways.

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Serial quantitative diffusion tensor MRI of the premature brain: Development in newborns with and without injury

Cited by 295 publications

References 16 publications

Regional Brain Development in Serial Magnetic Resonance Imaging of Low-Risk Preterm Infants

Regional Brain Development in Serial Magnetic Resonance Imaging of Low-Risk Preterm Infants

Score for Neonatal Acute Physiology–II and Neonatal Pain Predict Corticospinal Tract Development in Premature Newborns

Accelerated cerebral white matter development in preterm infants: A voxel-based morphometry study with diffusion tensor MR imaging

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