Serial proton MR spectroscopy of gray and white matter in relapsing-remitting MS

Abstract

Diffuse WM glial abnormalities were larger in magnitude than the axonal abnormalities and increased over time independently of conventional clinical or imaging metrics and despite immunomodulatory treatment. In contrast, the axonal abnormalities showed partial recovery, suggesting that patients' lower WM NAA levels represented a dysfunction, which may abate with treatment. Absence of detectable diffuse changes in GM suggests that injury there is minimal, focal, or heterogeneous between cortex and deep GM nuclei.

Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy

“…The major finding of our study was a reversible and significant decrease in the ratio of tNAA/tCr in CPZ-treated mice during demyelination, reflecting reversible axonal injury due to CPZ treatment. The observed alterations of the tNAA/tCr ratio during demyelination and spontaneous remyelination, were well in line with prior longitudinal studies in MS patients (Davie et al, 1994;Kirov et al, 2013;Mader et al, 2000) and MS animal models (Denic et al, 2009) (see Table S1 and Table S2). Interestingly a reversible increase in Tau/tCr ratio was observed in our study.…”

Application of metabolomics in autoimmune diseases: Insight into biomarkers and pathology

“…The two isoforms were found to have a positive correlation between their concentrations, suggesting a metabolic relationship between the two metabolites. Magnetic resonance spectroscopy (MRS) studies have shown increased myo-inositol in the brain of multiple sclerosis patients (Kirov et al, 2013;Vingara et al, 2013). Using 800 MHz 1 H-NMR spectroscopic to analyze CSF specimens from patients with multiple sclerosis, 15 metabolites from multiple sclerosis (n = 15) and non-multiple sclerosis (n = 17) patients were identified (Reinke et al, 2014).…”

“…Sample and analysis technique Biomarkers Lynch et al (1993) CSF, NMR spectroscopy Acetate, formate Nicoli et al (1996) CSF, MRS spectroscopy Lactate, pyruvate, alanine, lysine, valine, leucine-isoleucine, tyrosine, glutamine Simone et al (1996) CSF, MRS spectroscopy Lactate, formate, choline, glucose Aasly et al (1997) CSF, NMR spectroscopy Lactate, glutamine Lutz et al (2007) CSF, NMR spectroscopy Lactate, glutamine, fructose phenylalanine, β-hydroxyisobutyrate, acetate, β-glucose, creatinine, Regenold et al (2008) CSF, GC-MS spectroscopy Sorbitol, fructose, lactate Reinke et al (2014) CSF, NMR spectroscopy Choline, myo-inositol, 3-hydroxybutyrate, threonate, 2-hydroxyisovalerate, citrate, mannose, phenylalanine, Kirov et al (2013) Brain, MRSI spectroscopy N-acetylaspartate, choline, creatine, myo-inositol Mehrpour et al (2013) Serum, NMR spectroscopy Lipid, leucine/isoleucine, valine, lactate, alanine, glutamine, creatine, glucose, selenium Vingara et al (2013) Brain, MRS spectroscopy N-acetyl aspartate, lipids, myo-inositol, choline, creatine, γ-aminobutyric acid, glucose, aspartate Moussallieh et al (2014) Serum, NMR spectroscopy Scyllo-inositol, glutamine…”

Regional metabolic changes of supraventricular tissue in patients with relapsing-remitting and secondary-progressive multiple sclerosis

“…Применение таких методов, как позитронно-эмиссионная томография с 18-фтордезоксиглюко-зой (ПЭТ-ФДГ) [1,2], протонная магнитно-резо-нансная спектроскопия (1Н-МРС) [3][4][5][6][7][8], диффуз-но-тензорные изображения (ДТИ) [9], позволило обнаружить нарушения в тканях, не имеющих структурных изменений на традиционных МР-томограммах. ПЭТ-ФДГ позволяет оценить метабо-лические изменения в сером веществе головного мозга, указывая на снижение скорости метаболизма глюкозы в коре и подкорковых структурах, в то вре-мя как ДТИ позволяют оценить имеющиеся пора-жения структурно неизмененного белого вещества.…”

“…Вместе с тем результаты 1H-МРС-исследований головного мозга у пациентов с РС у зарубежных ис-следовательских групп даже при сходных критериях отбора пациентов неоднородны [3,7,8]. Однако ав-торы сходятся во мнении, что эта методика способ-на выявить изменения в головном мозге, не види-мые на традиционных МР-томограммах и позволят дополнить объем и увеличить качество получаемой диагностической информации.…”