Serial Precision of Metabolite Peak Area Ratios and Water Referenced Metabolite Peak Areas in Proton MR Spectroscopy of the Human Brain

Anxiety in healthy humans is associated with orbital frontal chemistry

“…These results were consistent with the data presented by Simmons et al, 25 who measured chemical ratios from samesized voxels, prescribed in the occipital lobe, and repeated five times on eight normal subjects. The reliability study performed on the same subjects over 3 months only slightly worsened the results.…”

“…The reliability study performed on the same subjects over 3 months only slightly worsened the results. 25 We used the ratios method relative to Cr because the effect of subject on total Cr peak and on each regional Cr peak height was non-significant (F = 0.35, P = 0.99). However, the CV determined for each regional Cr across all studied subjects showed regional variations: Cr in 26 State anxiety refers to anxiety felt at a particular moment, while trait anxiety refers to a habitual tendency to be anxious over a long period of time.…”

Recent Advances in Magnetic Resonance Neurospectroscopy

“…More recently, Venkatraman et al 124 compared the precision (reproducibility) and variability of singlevoxel PRESS data collected from the anterior cingulate and hippocampus at 4.0 T with reproducibility (single subject scanned multiple times) [125][126][127][128][129][130][131][132][133] and variability studies (many subjects scanned at least once) 109,115,120,128 -130,134 -144 from the literature (many different regions of the brain). The motivation for the Venkatraman study was the review of Steen et al, 145 who found an average coefficient of variation (CV, % ϭ SD/mean ϫ 100) for NAA by Steen et al 145 in the frontal lobe in healthy controls of 13.7% at 1.5 T (from 16 published studies).…”

Limits of a localized magnetic resonance spectroscopy assay for ex vivo myocardial triacylglycerol

“…For comparison, CV's from repeated bulk phantom measurements, which do not address localization, typically range between 2 to 4% [13][14][15], with accuracies around 6% [13]. This accuracy would deteriorate rapidly if localization became critical because OV contamination can be high [32,44].…”

“…Localized magnetic resonance spectroscopy (LMRS), which uses gradient-enabled imaging systems, is increasingly used both in basic and clinical assays including qualitative and quantitative compositional, temperature, and pH measurements [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Kreiss [16] summarized the main aspects of LMRS, including spectral artifacts, systematic errors, and general criteria for ensuring spectral quality.…”