Serial prealbumin levels as predictors of outcomes in a retrospective cohort of peritoneal and hemodialysis patients

Holland, David C; Meers, C; Lawlor, Marilyn E.; Lam, Miu

doi:10.1053/jren.2001.24358

Cited by 17 publications

(12 citation statements)

References 19 publications

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“…To address the problem of decreased protein intake as one of the causes of hypoalbuminemia, there probably is need to recognize negative nitrogen balance before frank hypoalbuminemia develops. While serum pre-albumin might appear attractive in this regard, in one retrospective study pre-albumin was not shown to predict future albumin levels, hospitalization, or mortality in PD subjects [14]. In another prospective study, a trend towards higher mortality (odds ratio 3.8; p = 0.09) was found in a small group of continuous ambulatory peritoneal dialysis (CAPD) subjects with serum pre-albumin <30 mg/dl [15].…”

Section: Discussionmentioning

confidence: 99%

Predictors of Hospitalization in Patients on Peritoneal Dialysis: The Missouri Experience

Trivedi

Tan²,

Prowant³

et al. 2007

Am J Nephrol

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Background: We analyzed a large number of demographic and biochemical variables to identify predictors of hospitalization in subjects on peritoneal dialysis (PD). Methods: All patients initiated on PD at our center from January 1990 through December 1999 were included. The following variables at the initiation of PD were included: demographics, clinical data, nutritional and adequacy parameters, transport characteristics, and various co-morbidities. Co-morbidities were graded for severity using a modified version of the Index of Coexistent Disease. Variables included during the course of PD consisted of weighted time average of a number of laboratory, adequacy, and nutritional parameters along with the number of peritonitis episodes per year. Stepwise linear regression was used following a univariate screening procedure to identify independent predictors of the outcome of hospitalization days per month on PD. Results: The subject population consisted of 191 subjects (105 men, 86 women; 180 Caucasians, 10 African-American, 1 Asian). The mean age was 61 ± 13 (SD) years and mean duration of follow-up was 21 ± 18 months. The baseline variable analysis revealed that the presence of partner to perform PD predicted increased hospitalization (p < 0.0001). Additionally, the presence and severity of peripheral vascular disease and residual renal Kt/V at baseline (negative association) predicted increased hospitalization. In the analyses of ongoing variables, stepwise linear regression solely identified weighted time average albumin as a strong negative predictor of hospitalization (p < 0.0001). Conclusion: A comprehensive analysis of a large number of variables revealed that serum albumin during the course of PD (negative association) and the need for partner to perform PD strongly predicted increased hospitalization in PD subjects.

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Section: Discussionmentioning

confidence: 99%

Predictors of Hospitalization in Patients on Peritoneal Dialysis: The Missouri Experience

Trivedi

Tan²,

Prowant³

et al. 2007

Am J Nephrol

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“…Pre-albumin is excreted through the kidney and transferrin is closely related to iron metabolism. Neither of these has been studied as thoroughly as albumin in CKD and ESRD patients [57][58][59] and further, it is expensive in some countries to check them regularly.…”

Section: Assessment Of Malnutrition In Patients With Chronic Kidney Dmentioning

confidence: 99%

Malnutrition in patients with chronic kidney disease

Chung¹,

Koh²,

Shin³

et al. 2012

OJIM

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Malnutrition is a major issue in patients with chronic kidney disease (CKD), adversely affecting morbidity, mortality, functional activity and patients’ quality of life. Our knowledge of the pathogenic mechanisms of malnutrition in patients with CKD, including endstage renal disease, has been improved. This has led to the development of clinical practice guidelines for nutritional care in CKD which provide a framework for the nutritional issues facing patients and physiccians. Extensive research in the field of nutrition in patients with CKD has resulted in the formation of general guidelines, although some uncertainties still exist on some of the best therapeutic or preventive options in uremic malnutrition. It is important to search actively for malnutrition since early diagnosis and treatment can improve the prognosis for CKD patients and reduce the monetary costs connected with treatment

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“…In man TTR serum levels fall due to decreased synthesis in inflammation and stress [13]. Human serum levels of TTR have been measured for hospital patients as an indicator of health status [4,11,22] and a number of commercial assays are available for this purpose. However, whether transthyretin is indeed a negative acute phase reactant has yet to be established for the pig.…”

Section: Introductionmentioning

confidence: 99%

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

et al. 2005

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-Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 µg/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 ± 8 µg/mL (n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection. acute phase proteins / pigs / infection Streptococcus suis

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Serial prealbumin levels as predictors of outcomes in a retrospective cohort of peritoneal and hemodialysis patients

Cited by 17 publications

References 19 publications

Predictors of Hospitalization in Patients on Peritoneal Dialysis: The Missouri Experience

Predictors of Hospitalization in Patients on Peritoneal Dialysis: The Missouri Experience

Malnutrition in patients with chronic kidney disease

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

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