Serial positron emission tomography scans following radiation therapy of patients with head and neck cancer

Greven, Kathryn M.; Williams, Daniel W.; McGuirt, W. Frederick; Harkness, Beth A.; D’Agostino, Ralph B.; Keyes, John W.; Watson, Nat E.

doi:10.1002/hed.1136

Cited by 255 publications

(141 citation statements)

References 12 publications

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“…Allal et al [7] and Roh et al [8] found that high FDG uptake correlated with advanced pT and pN stages. However, in several studies, the SUV max of primary tumor or all lesions, including regional metastatic lymph nodes, was not confirmed as a significant factor predicting clinical outcome in the patients with HNSCC undergoing radiation therapy with or without chemotherapy [11][12][13][26][27][28]. In our results, the lower The pT stage is defined as the extent of primary tumor in terms of size and invasion into the adjacent structure.…”

Section: Discussioncontrasting

confidence: 78%

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Choi

Yoo

Han

et al. 2010

Nucl Med Mol Imaging

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Purpose We assessed the prognostic value of metabolic tumor volume (MTV) measured using 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) inpatients with locally advanced head and neck squamous cell carcinoma (HNSCC). Methods We retrospectively reviewed 56 patients (51 men, five women; mean age 56.0±8.8years) who had locally advanced HNSCC and underwent FDG PET/CT for initial evaluation. All patients had surgical resection and radiotherapy with or without concurrent chemotherapy. The peak standardized uptake value (SUV peak ) and MTV of the target lesion, including primary HNSCC andmetastatic cervical lymph nodes, were measured from FDG PET/CT images. We compared SUV peak , MTV, and clinicopathologic variables such as age, Eastern Cooperative Oncology Group (ECOG) performance status, pN stage, pT stage, TNM stage, histologic grade and treatment modality to disease-free survival (DFS) and overall survival (OS). Results On the initial FDG PET/CT scans, the median SUV peak was 7.8 (range, 1.8-19.0) and MTV was17.0 cm 3 (range, 0.1-131.0 cm 3 ). The estimated 2-year DFS and OS rates were 67.2% and 81.8%. The cutoff points of SUV peak 6.2 and MTV 20.7 cm 3 were the best discriminative values for predicting clinical outcome. MTV and ECOG performance status were significantly related to DFS and OS on univariate and multivariate analyses (p<0.05). Conclusion The MTV obtained from initial FDG PET/CT scan is a significant prognostic factor for disease recurrence and mortality in locally advanced HNSCC treated with surgery and radiotherapy with or without chemotherapy.

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Section: Discussioncontrasting

confidence: 78%

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Choi

Yoo

Han

et al. 2010

Nucl Med Mol Imaging

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“…However, the range of cutoff values adopted in published studies to define patients at high or low risk of events markedly varied between 3.7 and 9 g/ml (median: 5.8). Noteworthy, also 2 negative studies are available in the literature (Ashamalla et al, 2014;Greven et al, 2001). In (Greven et al, 2001), patients with local recurrence had a mean pretreatment SUV Max of 7.7 g/ml versus 8.2 g/ml for patients without local recurrence.…”

Section: Suvmax and Metabolic Tumor Volumementioning

confidence: 99%

“…Noteworthy, also 2 negative studies are available in the literature (Ashamalla et al, 2014;Greven et al, 2001). In (Greven et al, 2001), patients with local recurrence had a mean pretreatment SUV Max of 7.7 g/ml versus 8.2 g/ml for patients without local recurrence. In (Ashamalla et al, 2014), SUVMax was correlated with OS in univariate analysis, but not in multivariate analysis.…”

Section: Suvmax and Metabolic Tumor Volumementioning

confidence: 99%

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Castelli

Bari

Depeursinge

et al. 2016

Critical Reviews in Oncology/Hematology

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International audience18 F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) allows to quantify the metabolic activity of a tumor (glycolysis) and has become a reference tool in oncology for the staging, restaging, radiotherapy planning and monitoring response in many cancers. Quantitative analyses have been introduced in order to overcome some of the limits of the visual methods, allowing an easier and more objective comparison of the inter- and intra-patients variations. The aims of this review were to report available evidences on the clinical value of quantitative PET/CT parameters in HNC. Forty-five studies, for a total of 2928 patients, were analyzed. Most of the data available dealt with the intensity of the metabolism, calculated from the Standard Uptake Value (SUV). Metabolic Tumor Volume (MTV) was well correlated with overall survival and disease free survival, with a higher predictive value than the maximum SUV. Spatial distribution of metabolism and textural analyses seems promising

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“…For example, radiotherapyinduced changes may be seen as fluorodesoxyglucose-avid lesions on positron emission tomography scanning up to 6 months or more after treatment. These are a well known false-positive results on follow-up exams after head and neck, rectal, and lung tumors [18][19][20][21]. An inflammatory wound has, by definition, not completed the healing process and is probably more at risk of complication under antiangiogenic treatment.…”

Section: Journal Of Surgical Oncologymentioning

confidence: 99%

Antiangiogenic agents and late anastomotic complications

Deshaies

Malka

Soria

et al. 2010

Journal of Surgical Oncology

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Anticancer agents targeting circulating vascular endothelial growth factor (VEGF) (e.g., bevacizumab and aflibercept) are strong angiogenesis inhibitors. As such, they may hamper the healing process, notably in the early postoperative period. Whether antiangiogenic agents may be associated with late postoperative healing complications is less known. We reviewed three cases of patients with anastomotic complications under antiangiogenic treatment occurring more than 1 year after initial surgery and we conducted a review of the literature. We report the first case of delayed anastomotic leakage which occurred under aflibercept therapy 13 months after a bilioenteric anastomosis and two cases of delayed rectal anastomotic complications associated with bevacizumab treatment 18 and 78 months after surgery. Fifteen similar cases of late gastrointestinal anastomotic complications were found in the English literature. Antiangiogenic agents are probably not deleterious to a healed wound. However, they appear to be associated with an increased risk of complications in a subgroup of patients. According to the 18 cases reported, the main risk factors appear to be low anterior resection for rectal cancer, perioperative radiotherapy, and early postoperative leak which heals through the formation of abundant and hypervascularized granulation tissue.

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Serial positron emission tomography scans following radiation therapy of patients with head and neck cancer

Cited by 255 publications

References 12 publications

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Antiangiogenic agents and late anastomotic complications

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