Serial Measurements of Serum Calcium, Magnesium, Parathyroid Hormone, Calcitonin, and 25-Hydroxy-Vitamin D in Premature and Term Infants during the First Week of Life

Hillman, Laura S.; Rojanasathit, Somkietr; Slatopolsky, Eduardo; Haddad, John G.

doi:10.1203/00006450-197706000-00009

Cited by 103 publications

(55 citation statements)

References 15 publications

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“…The concomitant increases in 1,25-(OH)2D and plasma Ca during the first week of life in our infants lends further support to the notion that vitamin D metabolism is of importance in the perinatal adjustment of mineral homeostasis. The lack of significant correlation between simultaneous 1,25-(0H)zD and Ca levels suggests, however, that other factors such as parathyroid function or Ca intake are also important (20,29).…”

Section: Resultsmentioning

confidence: 98%

Plasma Concentrations of Vitamin D Metabolites in Premature Infants

et al. 1984

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Section: Resultsmentioning

confidence: 98%

Plasma Concentrations of Vitamin D Metabolites in Premature Infants

et al. 1984

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“…On that basis, they concluded Al in the vaccines is safe. Hillman et al [161] found that parathyroid hormone is elevated in pre-term and full-term infants at 48 hours and up to 7 days. The pre-term infants had higher PTH than full term infants.…”

Section: Mechanism Of Impaired Excretion Of Aluminummentioning

confidence: 99%

Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders

CA¹

2013

Immunome Res

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Multisystem interactions are well established in neurological disorders, in spite of conventional views that only the central nervous system (CNS) is impacted. We review evidence for mutual interactions between the immune and nervous systems and show how these seem to be implicated in the origin and progression of nervous system disorders. Well-established immune system triggers leading to autoimmune reactions are considered. Of these, aluminum, a known neurotoxicant, may be of particular importance. We have demonstrated elsewhere that aluminum has the potential to induce damage at a range of levels in the CNS leading to neuronal death, circuit malfunction and ultimately, system failure. Aluminum is widely used as an adjuvant in various vaccine formulations and has been implicated in a multisystem disorder termed "autoimmune/inflammatory syndrome induced by adjuvants" (ASIA). The implications of aluminum-induced ASIA in some disorders of the CNS are considered. We propose a unified theory capturing a progression from a local response to a systemic response initiated by disruption of water-based interfaces of exposed cells.

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“…Late NH occurs after 1st week of life, usually symptomatic and requires long-term calcium therapy. [4][5][6] Another entity, resistant or prolonged hypocalcemia is defined as symptomatic hypocalcemia not responding to appropriate doses of calcium supplementation, calcium requirement beyond 72 h of age in neonates orhypocalcemia manifesting beyond 1st week of life. 1 The index case in this report is of late onset variety.…”

Section: Discussionmentioning

confidence: 99%

“…1 The early NH usually manifests within 72 hours after birth, requiring short term calcium supplementation, and it is a frequent co morbidity in high risk neonates. Maternal diabetes, prematurity and Perinatal asphyxia 1,[4][5][6][7] are the important causes of early NH. Late NH occurs after 1st week of life, usually symptomatic and requires long-term calcium therapy.…”

Section: Discussionmentioning

confidence: 99%

A Case of Neonatal Hypocalcaemia Due to Maternal Vitamin D Deficiency

Hasina

Hassan²

2017

Bangladesh J Child Health

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IntroductionNeonatal hypocalcaemia (NH) is a commonly reported metabolic abnormality in neonate. Ionized calcium is vital for various metabolic pathways like blood coagulation, neuronal depolarization, integrity of cell membrane, enzyme catalysis etc. Major part of the body calcium exists in bones and muscles (99%) and the rest of the calcium is present in extracellular fluid (1%). In extracellular fluid about 40% calcium is bound to albumin, another 10% is bound to citrate, phosphorus, lactate and sulfate and the rest (50%) exists as ionized free form, help in metabolic functions. 1,2 Hypocalcaemia has significant negative impact on newborn health. It is defined as total serum calcium of <8 mg/dL (2 mmol/L) or ionized calcium of <1.2 mmol/L in term neonates, and<7 mg/dL (1.75 mmol/L) of total calcium or <4 mg/dL (1 mmol/L) of ionized calcium in preterm infants. 3 Causes of neonatal hypocalcaemia is diverse like prematurity, perinatal asphyxia, cow milk feeding. Maternal Vitamin D deficiency has also been reported as a cause of neonatal hypocalcaemia. We are reporting a case of neonatal hypocalcaemia attributed to maternal Vitamin D deficiency in Asian context. Case Report 9 days old out born boy was admitted in NICU of Apollo Hospitals Dhaka on 3 rd September 2014 with h/o seizures. In immediate neonatal period, in a different hospital where he was born, the baby developed mild transient tachypnoea of newborn which required no active management. He was discharged from that hospital on 3 rd postnatal day. At 7 th day of age he developed convulsion and was re-admitted to that hospital. His convulsion was generalized in nature, 4-5 episodes with duration of approximately 10 seconds each. He was initially treated in that hospital with anticonvulsant, antibiotic and calcium gluconate but as condition was deteriorating, he was transferred to Apollo hospital at 9 th day of age. The pregnancy was unremarkable and the baby was born at term by an uncomplicated caesarian section. His birth weight was 2580 gram (10th to 25th percentile). Mother had bronchial asthma, otherwise family history was noncontributory. There was no history of fever, trauma or sepsis related risk factors. The baby was breastfed and supplemented with formula feed. The baby's weight was 2580gram. He was afebrile with normal vital signs. He had no dysmorphic features and physical examination was otherwise unremarkable. Twenty four hours after admission, the baby developed 2 episodes of focal convulsion for 10 seconds each. A Case of NeonatalInitial blood work showed normal septic screening, renal function and electrolytes with hypocalcemia (total calcium 6 mg/dl (8.5 to 10.5 mg/dl ) and hyperphosphataemia. Blood glucose level was 4.3mmol/L. The diagnosis was revealed after further maternal history and blood tests. On further query, the mother did not take any antenatal vitamin supplements. The baby had not been started on vitamin D supplements.Vitamin D deficiency in the infant was diagnosed on the basis of a low 25-hydroxy vitamin D level at 19 nmol/...

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Serial Measurements of Serum Calcium, Magnesium, Parathyroid Hormone, Calcitonin, and 25-Hydroxy-Vitamin D in Premature and Term Infants during the First Week of Life

Cited by 103 publications

References 15 publications

Plasma Concentrations of Vitamin D Metabolites in Premature Infants

Plasma Concentrations of Vitamin D Metabolites in Premature Infants

Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders

A Case of Neonatal Hypocalcaemia Due to Maternal Vitamin D Deficiency

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