Serial measurements of body composition using bioelectrical impedance and clinical usefulness of phase angle in colorectal cancer

Abstract

Background: Although body composition (BC) can be measured easily using bioelectrical impedance analysis (BIA), there are few studies of serial BC measurements in colorectal cancer (CRC). The purpose of the present study was to observe the serial change of BC in patients with CRC surgery from the initiation to the end of chemotherapy and to evaluate its clinical usefulness. Methods: From July 2018 to November 2019, patients undergoing elective CRC surgery were enrolled. All clinical data were reviewed retrospectively. BIA data were collected prospectively at four time points (initial, discharge day, first chemotherapy, and 6 months later). BC was measured using a commercial BIA device. Results: A total of 160 patients were enrolled, and 110 (68.8%) patients were followed. Most BC measurements, such as weight, body mass index, skeletal muscle mass, skeletal muscle index, and fat mass index, were lowest at the first chemotherapy and rebounded after 6 months. Phase angle (PhA) and the ratio of extracellular water to total body water (ECW/TBW) were "V" shaped and inverted "V" shaped, respectively, and the peaks were on discharge days. This pattern of BC showed significant difference according to sarcopenia, old age (>70 years), and advanced stage (III or IV). The change of PhA and ECW/TBW sensitively pattern differences according to clinical aspect. Conclusions: Using BIA, serial BC measurements were taken to establish a pattern based on clinical characteristics. PhA showed the most sensitive change according to the patient's clinical aspect.

Association between phase angle and adverse clinical outcomes in hospitalized patients with COVID‐19: A systematic review

“…The findings of this review confirm that PhA decreases with advancing age, in line with the results of other studies 17,29,31,32 . This is because of the loss of muscle mass and the gain of fat tissue, which can be attributed to the natural aging process 45 .…”

“…The mean values of the PhA of the selected studies are in line with the results of other studies 17,29,40,41 . The highest PhA means were observed in studies with patients hospitalized exclusively in wards 25,28 .…”

“…[36][37][38][39] The mean values of the PhA of the selected studies are in line with the results of other studies. 17,29,40,41 The highest PhA means were observed in studies with patients hospitalized exclusively in wards. 25,28 It should be noted that the studies included in this review presented different reference values for PhA analysis.…”

“…The results of five studies 22–24,26,27 demonstrated that lower PhA values were associated with worsening of the clinical condition of these patients, evidencing its potential as a predictor of adverse clinical outcomes. Similarly, the literature has shown that PhA can be used as a prognostic parameter in several clinical situations such as cancer, 15,17,29 heart failure, 30,31 kidney disease, 32,33 and HIV infection 34,35 …”

“…The findings of this review confirm that PhA decreases with advancing age, in line with the results of other studies. 17 , 29 , 31 , 32 This is because of the loss of muscle mass and the gain of fat tissue, which can be attributed to the natural aging process. 45 It is worth mentioning that lean tissues are highly electrical current conductors, as they have a large amount of water and electrolytes.…”