Serial magnetization transfer imaging to characterize the early evolution of new MS lesions

Silver, N. C.; Lai, M.O.; Symms, Mark R.; Barker, Gareth J.; McDonald, W. I.; Miller, David H.

doi:10.1212/wnl.51.3.758

Cited by 95 publications

(54 citation statements)

References 11 publications

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“…12 On average, MTR drops dramatically when the lesions start to enhance and may show a partial or complete recovery in the subsequent 1-6 six months.…”

Section: Mt-mri In Msmentioning

confidence: 98%

“…Homogeneously enhancing lesions, which may represent new active lesions, have significantly higher MTR values than do ring-enhancing lesions, [12][13][14][15] which may represent old, reactivated lesions. The duration of enhancement is also associated with different degrees of MTR changes in new MS lesions: lesions enhancing on at least two consecutive monthly scans have lower MTR than those enhancing on a single scan, 16 suggesting that a longer enhancement in MS lesions may be related to a more severe tissue damage.…”

Section: Mt-mri In Msmentioning

confidence: 99%

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Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Filippi

Rocca

2007

Neurotherapeutics

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Summary:Magnetic resonance imaging is highly sensitive in revealing CNS abnormalities associated with several neurological conditions, but lacks specificity for their pathological substrates. In addition, MRI does not allow evaluation of the presence and extent of damage in regions that appear normal on conventional MRI sequences and that postmortem studies have shown to be affected by pathology. Quantitative MR-based techniques with increased pathological specificity to the heterogeneous substrates of CNS pathology have the potential to overcome such limitations. Among these techniques, one of the most extensively used for the assessment of CNS disorders is magnetization transfer MRI (MT-MRI). The application of this technique for the assessment of damage in macroscopic lesions, in normal-appearing white and gray matter, and in the spinal cord and optic nerve of patients with several neurological conditions is providing important in vivo information-dramatically improving our understanding of the factors associated with the appearance of clinical symptoms and the accumulation of irreversible disability. MT-MRI also has the potential to contribute to the diagnostic evaluation of several neurological conditions and to improve our ability to monitor treatment efficacy in experimental trials.

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“…12 On average, MTR drops dramatically when the lesions start to enhance and may show a partial or complete recovery in the subsequent 1-6 six months.…”

Section: Mt-mri In Msmentioning

confidence: 98%

Section: Mt-mri In Msmentioning

confidence: 99%

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Filippi

Rocca

2007

Neurotherapeutics

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“…Using MT imaging for regionof-interest analyses, however, MS lesions are more conspicuous and MTR values provide information on lesion evolution. 35,36 More recently, the diffuse characteristics of MS have been characterized by plotting the MTR histogram of the whole brain (Fig. 9).…”

Section: Applications In Imagingmentioning

confidence: 99%

Magnetization transfer in MRI: a review

2001

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This review describes magnetization transfer (MT) contrast in magnetic resonance imaging. A qualitative description of how MT works is provided along with experimental evidence that leads to a quantitative model for MT in tissues. The implementation of MT saturation in imaging sequences and the interpretation of the MT-induced signal change in terms of exchange processes and direct effects are presented. Finally, highlights of clinical uses of MT are outlined and future directions for investigation proposed.

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“…However, new imaging techniques, which allow more accuracy inmonitoring the disease evolution, provide evidence of tissue damage in the normal appearing white matter (NAWM) preceding the appearance of newcontrast-enhancing lesions. A decrease in magnetization transfer ratio (MTR) is described prior to enhancement, indicating a diminished ability for saturation exchange due to edema and inflammation [3,4]. Changes in the lipid spectra have been noted in magnetic resonance spectroscopy preceding lesions [5].…”

Section: Introductionmentioning

confidence: 99%

Cerebral blood perfusion changes in multiple sclerosis

Wuerfel

Paul

Zipp

2007

Journal of the Neurological Sciences

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| The proximity of immune cell aggregations to the vasculature is a hallmark of multiple sclerosis. Furthermore, it is widely accepted that inflammation is able to modulate the microcirculation. Until recently, the detection of cerebral blood perfusion changes was technically challenging, and perfusion studies in multiple sclerosis patients yielded contradictory results. However, new developments in fast magnetic resonance imaging have enabled us to image the cerebral hemodynamics based on the dynamic tracking of a bolus of paramagnetic contrast agents (dynamic susceptibility contrast). This review discusses the technical principles, possible pitfalls, and potential for absolute quantification of cerebral blood volume and flow in a clinical setting. It also outlines recent findings on inflammation associated perfusion changes, which are inseparable from pathological considerations in multiple sclerosis.

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Serial magnetization transfer imaging to characterize the early evolution of new MS lesions

Abstract: The lack of observable change in MTR before the first detectable gadolinium enhancement within MS lesions suggests that blood-brain barrier disruption is closely related to, but not preceded by, demyelination.

Cited by 95 publications

References 11 publications

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Magnetization transfer in MRI: a review

Cerebral blood perfusion changes in multiple sclerosis

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