Serial Lung Function and Elastic Recoil 2 Years After Lung Volume Reduction Surgery for Emphysema

Gelb, Arthur F.; Brenner, Matthew; McKenna, Robert J.; Fischel, Richard; Zamel, Noé; Schein, Mark J.

doi:10.1378/chest.113.6.1497

Cited by 46 publications

(50 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3][4][5] The results also confirm previous reports of a decrease in overall lung volume, measured both by body plethysmography (table 1) and CT (table 2), and a decrease in the volume of the lung occupied by emphysematous lesions larger than 5 mm in diameter. The power law analysis extends these observations by providing a quantitative method for reliably detecting the location and size of the emphysematous lesions.…”

Section: Discussionsupporting

confidence: 90%

“…[1][2][3][4][5] The data show that improvement in lung function occurs in all subjects, but is maintained much longer in patients with a heterogeneous distribution of disease. 6 Furthermore, a recent finding from the National Emphysema Treatment Trial (NETT) Research Group has identified a group of patients characterised by homogeneous disease, low forced expiratory volume in 1 second (FEV 1 ), and a very low carbon monoxide transfer factor who have increased morbidity and mortality following LVRS.…”

mentioning

confidence: 87%

See 1 more Smart Citation

New onset asthma and respiratory symptoms are more prevalent in radiographers than in physiotherapists

Khair

2003

Thorax

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 87%

New onset asthma and respiratory symptoms are more prevalent in radiographers than in physiotherapists

Khair

2003

Thorax

View full text Add to dashboard Cite

“…This technique induces a one-time benefit improvement, peaking at 3-6 months after surgery, in terms of lung function, exercise tolerance, and quality of life [74][75][76][77]. The retrospective nature of patient selection and the inability to accurately quantify the amount of resected emphysematous lung tissue are two major obstacles in defining criteria for candidate9s selection for LVRS [75].…”

Section: Surgical Treatment Of Emphysemamentioning

confidence: 99%

Quantitative computed tomography assessment of lung structure and function in pulmonary emphysema

2001

View full text Add to dashboard Cite

Quantitative computed tomography assessment of lung structure and function in pulmonary emphysema. A. Madani, C. Keyzer, P.A. Gevenois. #ERS Journals Ltd 2001. ABSTRACT: Accurate diagnosis and quantification of pulmonary emphysema during life is important to understand the natural history of the disease, to assess the extent of the disease, and to evaluate and follow-up therapeutic interventions.Since pulmonary emphysema is defined through pathological criteria, new methods of diagnosis and quantification should be validated by comparisons against histological references.Recent studies have addressed the capability of computed tomography (CT) to quantify pulmonary emphysema accurately. The studies reviewed in this article have been based on CT scans obtained after deep inspiration or expiration, on subjective visual grading and on objective measurements of attenuation values. Especially dedicated software was used for this purpose, which provided numerical data, on both two-and three-dimensional approaches, and compared CT data with pulmonary function tests.More recently, fractal and textural analyses were applied to computed tomography scans to assess the presence, the extent, and the types of emphysema. Quantitative computed tomography has already been used in patient selection for surgical treatment of pulmonary emphysema and in pharmacotherapeutical trials. Computed tomography (CT) is an imaging method providing transverse anatomical images in which the value of each picture element (i.e. pixel) corresponds to the x-ray attenuation of a defined volume of tissue (i.e. voxel). The X-ray attenuation values for each set of projections (i.e. slice) are registered by the computer and organized in a matrix form. The number of calculated pixels determines the image matrix size, influences the image resolution, and should thus be as high as possible. In clinical practice, the matrix size is actually 5126512 pixels. The X-ray attenuation, also called tissue density, is numerically expressed in Hounsfield units (HU). The scale of attenuation values ranges from -1,000 HU, corresponding to the attenuation value of air, to 3,000 HU, with 0 HU corresponding to the attenuation value of water. The thousands of pixels included in one scan make CT the most precise morphological method able to assess the pulmonary structure in vivo [1].In pulmonary emphysema, the major advantage of CT is that in addition to providing data concerning overall lung destruction, it also identifies the specific locations in the lung where the alveolar surface has been destroyed. The ability to estimate the extent and severity of pulmonary emphysema during life is important for several reasons. 1) Accurate detection of lung destruction when it appears and careful mapping of its progression are required to understand the natural history of emphysema.2) The treatment of advanced disease by lung volume reduction surgery (LVRS) requires knowledge of the location of the lesions and objective methods of assessing the surgical

show abstract

“…2 The operation was based on the hypothesis that reducing lung size would restore elastic recoil and radial traction on the terminal bronchioles, therefore improving lung function and chest wall mechanics. [3][4][5] Several controlled trials [6][7][8] showed that LVRS for emphysema improved lung function, exercise capacity, 9 10 and quality of life; 11 however, it is also clear that not all patients benefit from LVRS. Moreover, despite careful case selection and regardless of whether an open sternotomy/thoracotomy or video-assisted approach is utilised, published operative mortality rates vary from 0 to 19% with postoperative morbidity high.…”

mentioning

confidence: 99%

Relation of interlobar collaterals to radiological heterogeneity in severe emphysema

Higuchi

Reed

Oto

et al. 2006

Thorax

View full text Add to dashboard Cite

Serial Lung Function and Elastic Recoil 2 Years After Lung Volume Reduction Surgery for Emphysema

Abstract: Two years post-LVRS, there is variable clinical and physiologic improvement that does not correlate with any baseline parameter. Increased lung elastic recoil appears to be the primary mechanism for improved airflow limitation.

Cited by 46 publications

References 46 publications

New onset asthma and respiratory symptoms are more prevalent in radiographers than in physiotherapists

New onset asthma and respiratory symptoms are more prevalent in radiographers than in physiotherapists

Quantitative computed tomography assessment of lung structure and function in pulmonary emphysema

Relation of interlobar collaterals to radiological heterogeneity in severe emphysema

Contact Info

Product

Resources

About